Ifng

  • Official Full Name

    interferon, gamma
  • Overview

    This gene encodes a member of the type II interferon family. The protein encoded is a soluble cytokine with antiviral, immunoregulatory and anti-tumor properties and is a potent activator of macrophages. Mutations in this gene are associated with aplastic anemia.[provided by RefSeq, Nov 2009]
  • Synonyms

    IFNG;interferon, gamma;IFG;IFI;interferon gamma;IFN-gamma;immune interferon

Recombinant Proteins

  • Human
  • Ferret
  • Cynomolgus
  • Mouse
  • Bovine
  • Porcine
  • Rhesus macaque
  • Rat
  • Rabbit
  • Marmota monax (Woodchuck)
  • Equine
  • Pig
  • Horse
  • Ovine
  • Chicken
  • Cattle
  • Dog
  • Guinea pig
  • Sheep
  • Hamster
  • Zebrafish
  • Canine
  • Goat
  • Siniperca chuatsi (Mandarin fish)
  • Golden hamster
  • HEK293
  • E.coli
  • Yeast
  • Barley Grain
  • CHO
  • Hordeum Vulgare
  • COS-7 cells
  • Mammalian Cells
  • Human Cells
  • C-His
  • Non
  • His
  • Fc
  • Strep II
  • Fc&His
  • His&T7
  • GST&His
  • GST
  • Flag&His
  • Avi&Fc&His
  • DDK&Myc
  • His&Myc
  • Avi&His
  • His&Strep II
  • Flag
  • Fc&Flag
Cat.# Product name Source (Host) Species Tag Protein Length Price
IFNG-510H Active Recombinant Human IFNG HEK293 Human Non 24-166 a.a.
AIFM3-9505H Recombinant Human AIFM3 protein, His-tagged E.coli Human His 355-598 aa
IFNG-4340F Recombinant Ferret IFNG Protein Yeast Ferret Non 164aa
IFNG-1165C Active Recombinant Cynomolgus IFNG Protein E.coli Cynomolgus Non 24-165 a.a.
Ifng-11M Active Recombinant Mouse Ifng E.coli Mouse Non
IFNG-1367H Active Recombinant Human IFNG E.coli Human Non 140 a.a.
IFNG-24H Active Recombinant Human IFNG, His-tagged Barley Grain Human His
IFNG-26H Active Recombinant Human Interferon, Gamma HEK293 Human Non
IFNG-473H Active Recombinant Human IFNG, Met-tagged E.coli Human 24-166 a.a.
Ifng-601M Active Recombinant Mouse Ifng E.coli Mouse His23-Cys155
IFNG-61B Active Recombinant Bovine Interferon, Gamma Yeast Bovine Non
IFNG-8549H Active Recombinant Human IFNG protein(Met1-Gln166) CHO Human Non Met1-Gln166
IFNG-857B Active Recombinant Bovine IFNG E.coli Bovine Gln24-Thr166 & Gln24-Arg162
IFNG-8860H Active Recombinant Human IFNG, His-tagged Hordeum Vulgare Human Non
IFNG-893M Active Recombinant Mouse IFNG Protein, His-tagged HEK293 Mouse His 1-155 a.a.
IFNG-01HG Active GMP Recombinant Human IFNG Protein CHO Human
Ifng-01M Active Recombinant Mouse Ifng Protein, His-Tagged E.coli Mouse His
IFNG-01P Active GMP Recombinant Porcine IFNG Protein, His-Tagged E.coli Porcine His
IFNG-084H Active Recombinant Human IFNG Protein E.coli Human 24-166 a.a.
IFNG-1165R Active Recombinant Rhesus Protein E.coli Rhesus macaque Non Gln24-Gln165
IFNG-157H Active Recombinant Human interferon, gamma Protein, His tagged HEK293 Human His 24-161aa
IFNG-158HG Active GMP Recombinant Human IFNG protein E.coli Human Non
IFNG-30HG Active Recombinant Human IFNG Protein (Gln24-Gln166), GMP Grade, Animal-Free E.coli Human Gln24-Gln166
IFNG-09H Recombinant Human Interferon Gamma E.coli Human Non
Ifng-10M Recombinant Mouse Ifng protein(His23-Cys155) E.coli Mouse Non His23-Cys155
Ifng-114M Recombinant Mouse Ifng protein E.coli Mouse Non 133
Ifng-115R Recombinant Rat Ifng protein E.coli Rat Non 134
IFNG-1164R Recombinant Rhesus IFNG protein(Met1-Gln165), His-tagged HEK293 Rhesus macaque His 1-165 a.a.
IFNG-116H Recombinant Human IFNG protein HEK293 Human 143
IFNG-116R Recombinant Rabbit IFNG Yeast Rabbit Non
Ifng-119M Recombinant Mouse Ifng protein(Met1-Cys155), hFc-tagged HEK293 Mouse Fc 1-155 a.a.
Ifng-11R Recombinant Rat Interferon-γ E.coli Rat Non
IFNG-1254M Recombinant Marmota monax IFNG Protein, His-tagged Yeast Marmota monax (Woodchuck) His 24-166 a.a.
IFNG-130B Recombinant Bovine Interferon, Gamma COS-7 cells Bovine Non
IFNG-145H Recombinant Human Interferon, Gamma, His-tagged E.coli Human His
IFNG-15833H Recombinant Human IFNG, His-tagged E.coli Human His 24-161aa
IFNg-19E Recombinant Equine IFN gamma Yeast Equine Non
IFNG-21P Recombinant Porcine Interferon-gamma E.coli Pig Non
IFNG-2207R Recombinant Rhesus monkey IFNG Protein, His-tagged Mammalian Cells Rhesus macaque His
IFNG-257H Recombinant Human IFNG, StrepII-tagged Human Cells Human Strep II 24-161, 138 a.a.
IFNG-28243TH Recombinant Human IFNG, His-tagged E.coli Human His Full L. 24-166 a.a.
IFNG-28244TH Recombinant Human IFNG, His-tagged E.coli Human His 24-166 a.a.
IFNg-28R Recombinant Rabbit IFN gamma Yeast Rabbit Non
IFNG-29196TH Recombinant Human IFNG E.coli Human Non 143 amino acids
IFNG-2997R Recombinant Rat IFNG Protein Mammalian Cells Rat His
IFNg-31H Recombinant Human IFN gamma Yeast Human Non
IFNG-325F Recombinant Ferret IFNG, His tagged Human Cells Ferret Fc&His 1-166 a.a.
IFNG-440E Recombinant Horse IFNG protein E.coli Horse Non 143
Ifng-470R Recombinant Rat Ifng protein, His-tagged HEK293 Rat His Gln23~Cys156
IFNG-480H Recombinant Human IFNG protein, His-tagged HEK293 Human His Gln24~Gln166
Ifng-488M Recombinant Mouse Ifng protein, His-tagged HEK293 Mouse His His23~Cys155
IFNG-497R Recombinant Rabbit IFNG protein, His-tagged HEK293 Rabbit His Gln24~Tyr167
Ifng-510M Active Recombinant Mouse Ifng protein HEK293 Mouse Non Met1-Cys155
IFNg-51O Recombinant Ovine IFN gamma Yeast Ovine Non
Ifng-532M Recombinant Mouse Ifng protein, His-tagged E.coli Mouse His His23~Cys155
Ifng-549R Recombinant Rat Ifng protein, His-tagged E.coli Rat His Gln23~Cys156
IFNG-605H Recombinant Human IFNG protein E.coli Human Non 144
IFNG-612C Recombinant Cynomolgus IFNG protein, His-tagged C-His Cynomolgus Gln24-Gln165
IFNG-63C Recombinant Chicken Interferon, Gamma Yeast Chicken Non
IFNG-64E Recombinant Equine Interferon, Gamma Yeast Equine Non
IFNG-6706C Recombinant Chicken IFNG Mammalian Cells Chicken His
IFNG-685H Recombinant Human Interferon, Gamma, HQ-tagged Hordeum Vulgare Human Non
Ifng-7469R Active Recombinant Rat Ifng protein, hFc-tagged HEK293 Rat Fc Met1-Cys156
IFNG-800C Recombinant Cattle IFNG protein, His-tagged E.coli Cattle His Gln24~Thr166
IFNG-801D Recombinant Dog IFNG protein, His & T7-tagged E.coli Dog His&T7 Gln24~Lys166
IFNG-802C Recombinant Chicken IFNG protein, His-tagged E.coli Chicken His His20~Cys164
Ifng-803G Recombinant Guinea pig Ifng protein, His-tagged E.coli Guinea pig His Gln24~Lys166
IFNG-804S Recombinant Sheep IFNG protein, His-tagged E.coli Sheep His Gln24~Met166
IFNG-805P Recombinant Pig IFNG protein, His-tagged E.coli Pig His Ser21~Lys166
Ifng-806R Recombinant Rat Ifng protein, His & GST-tagged E.coli Rat GST&His Gln23~Cys156
IFNG-807R Recombinant Rabbit IFNG protein, His-tagged E.coli Rabbit His Gln24~Tyr167
IFNG-94H Recombinant Human Interferon Gamma CHO Human Non 1-166 a.a.
IFNG-001HCL Recombinant Human IFNG cell lysate CHO Human Non
IFNG-1007FCL Recombinant Ferret IFNG cell lysate Human Cells Ferret Non
IFNG-1536RCL Recombinant Rat IFNG cell lysate Human Cells Rat Non
IFNG-1797MCL Recombinant Mouse IFNG cell lysate Human Cells Mouse Non
ADPRH-2543H Recombinant Human ADPRH protein, GST-tagged E.coli Mouse GST 1-357 aa
ADPRHL1-2342H Recombinant Human ADPRHL1 protein, His-tagged E.coli Human His 1-272 aa
ADRA1B-2533H Recombinant Human ADRA1B protein, His-tagged E.coli Human His 381-520 aa
ADRBK2-3533H Recombinant Human ADRBK2 protein, His-tagged E.coli Human His 1-387 aa
Ifng-009I Active Recombinant Rat Ifng Protein (135 aa) E.coli Rat 135
Ifng-019H Recombinant Hamster Ifng Protein, Met1-Ile174, C-His tagged HEK293 Hamster His Met1-Ile174
Ifng-031I Active Recombinant Mouse Ifng Protein (134 aa) E.coli Mouse 134
Ifng-046R Recombinant Rat interferon gamma Protein, His&Flag tagged HEK293 Rat Flag&His 23-156aa
Ifng-063M Recombinant Mouse interferon gamma Protein, His&Flag tagged HEK293 Mouse Flag&His 23-155aa
Ifng-077M Active Recombinant Mouse Ifng Protein E.coli Mouse 23-155 a.a.
Ifng-078M Active Recombinant Mouse Ifng Protein E.coli Mouse
IFNG-105I Active Recombinant Human IFNG Protein (144 aa) E.coli Human 144
IFNG-1150H Recombinant Human IFNG Protein, His (Fc)-Avi-tagged HEK293 Human Avi&Fc&His
IFNG-1150H-B Recombinant Human IFNG Protein Pre-coupled Magnetic Beads HEK293 Human
IFNG-115H Active Recombinant Human IFNG Protein E.coli Human
IFNG-116M Active Recombinant Mouse IFNG Protein E.coli Mouse
IFNG-117R Recombinant Rat IFNG Protein E.coli Rat
IFNG-1184H Recombinant Human IFNG Protein, MYC/DDK-tagged HEK293 Human DDK&Myc
Ifng-118R Recombinant Rat IFNG Protein, Fc-His-tagged(C-ter) HEK293 Rat Fc&His Gln23-Cys156
IFNG-119H Recombinant Active Human IFNG Protein, His-tagged(C-ter) E.coli Human His
IFNG-13Z Recombinant Zebrafish IFN gamma 1 Protein, 146 Yeast Zebrafish
IFNG-156H Active Recombinant Human IFNG Protein (Gln24-Gln166), C-His tagged, Animal-free, Carrier-free E.coli Human His Gln24-Gln166
IFNG-157HG Active GMP Recombinant Human IFNG Protein HEK293 Human Non 24-166 a.a.
Ifng-192R Active Recombinant Rat Ifng Protein E.coli Rat Non
IFNG-198P Active Recombinant Pig IFNG Protein (Gln23-Lys166), C-His tagged, Animal-free, Carrier-free E.coli Pig His Gln23-Lys166
IFNG-2028R Recombinant Rhesus Macaque IFNG Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque Avi&Fc&His
IFNG-2028R-B Recombinant Rhesus Macaque IFNG Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
IFNG-21H Active Recombinant Human IFNG Protein, Animal Free Human Cells Human
IFNG-22H Active Recombinant Human IFNG Protein E.coli Human
IFNG-2404F Recombinant Ferret IFNG protein(Met1-Lys166), His-tagged HEK293 Ferret His Met1-Lys166
IFNG-241H Active Recombinant Human IFNG Protein E.coli Human Non
IFNG-2506H Recombinant Human IFNG Protein (Gln24-Gln166) Mammalian Cells Human Non Gln24-Gln166
IFNG-2508H Recombinant Human IFNG Protein (Gln24-Gly161), N-His tagged E.coli Human His Gln24-Gly161
Ifng-263I Active Recombinant Rat Ifng Protein CHO Rat
IFNG-264I Active Recombinant Human IFNG Protein CHO Human
IFNG-2653R Recombinant Rat IFNG Protein, His (Fc)-Avi-tagged HEK293 Rat Avi&Fc&His
IFNG-2653R-B Recombinant Rat IFNG Protein Pre-coupled Magnetic Beads HEK293 Rat
IFNG-3075C Recombinant Chicken IFNG protein, GST-tagged E.coli Chicken GST 20-164aa
Ifng-3076M Recombinant Mouse Ifng protein, His-tagged E.coli Mouse His 27-155aa
IFNG-3077M Recombinant Marmota monax (Woodchuck) IFNG protein, His-tagged E.coli Marmota monax (Woodchuck) His 24-166aa
Ifng-3078R Recombinant Rat Ifng protein, GST-tagged E.coli Rat GST 23-156aa
IFNg-3366P Recombinant Pig IFNg protein, His-tagged HEK293 Pig His Ser21~Lys166
IFNG-33CFL Recombinant Full length Canine interferon gamma Protein, Tag Free Yeast Canine Non Full L. 1-166aa
IFNG-359C Recombinant Cynomolgus Monkey IFNG Protein, His (Fc)-Avi-tagged HEK293 Cynomolgus Avi&Fc&His
IFNG-359C-B Recombinant Cynomolgus Monkey IFNG Protein Pre-coupled Magnetic Beads HEK293 Cynomolgus
Ifng-365MG Active GMP Recombinant Mouse Ifng protein HEK293 Mouse DNA sequence encoding Mouse Ifng (NP_032363.1) was expressed with His tag at the C-terminal.
Ifng-378I Active Recombinant Rat Ifng Protein (134 aa) E.coli Rat 134
Ifng-379I Active Recombinant Mouse Ifng Protein (134 aa) E.coli Mouse 134
IFNG-380I Active Recombinant Human IFNG Protein (144 aa) E.coli Human 144
Ifng-42M Active Recombinant Mouse Ifng Protein (His23-Cys155), C-His tagged, Animal-free, Carrier-free E.coli Mouse His His23-Cys155
IFNG-4318G Recombinant Goat IFNG protein, His&Myc-tagged E.coli Goat His&Myc 24-166aa
IFNG-4347HG GMP Recombinant Human IFNG protein E.coli Human Non 144
IFNG-497H Recombinant Human IFNG Protein Human 166
IFNG-50H Recombinant Human IFNG Protein E.coli Human Full L.
IFNG-5432H Recombinant Human IFNG protein, His-tagged Yeast Human His 24-161aa
IFNG-5433S Recombinant Sheep IFNG protein, His-tagged Yeast Sheep His 24-166aa
IFNG-5677S Recombinant Mandarin fish IFNG Protein (Met1-Ala208), His tagged E.coli Siniperca chuatsi (Mandarin fish) His Met1-Ala208
Ifng-5686M Recombinant Mouse Ifng Protein (His23-Cys155), C-His tagged Mammalian Cells Mouse His His23-Cys155
IFNG-5744C Recombinant Cynomolgus monkey IFNG protein, His-tagged Yeast Cynomolgus His 24-165aa
IFNG-579H Recombinant Human IFNG protein, His-Avi-tagged HEK293 Human Avi&His Gln24-Gly161
IFNG-579HB Recombinant Human IFNG protein, His-Avi-tagged, Biotinylated HEK293 Human Avi&His Gln24-Gly161
IFNG-587HG Active GMP Recombinant Human IFNG protein CHO Human
IFNG-6015H Active Recombinant Human IFNG protein E.coli Human Non Gln24-Gln166
IFNG-632G Recombinant Golden hamster IFNG protein, His&Strep II-tagged E.coli Golden hamster His&Strep II 24-174a.a.
IFNG-6633C Recombinant Cynomolgus monkey IFNG protein, His-tagged E.coli Cynomolgus His 24-165a.a.
Ifng-6731M Recombinant Mouse Ifng Protein (His23-Cys155) E.coli Mouse Non His23-Cys155
Ifng-6732M Recombinant Mouse Ifng Protein (His23-Cys155) Mammalian Cells Mouse Non His23-Cys155
IFNG-67H Human Interferon Gamma (Leukocyte derived) Reference standard Human Non
IFNG-72HFL Recombinant Full Length Human IFNG Protein, C-Flag-tagged Mammalian Cells Human Flag Full L.
IFNG-74H Recombinant Human IFNG Protein Human Cells Human 24-166 a.a.
IFNG-74R Recombinant Rhesus IFNG protein E.coli Rhesus macaque Non 142
IFNG-7822C Recombinant Canine IFNG protein E.coli Canine Non 143
IFNG-78H Recombinant Human IFNG Protein E.coli Human Non
IFNG-8157B Recombinant Bovine IFNG protein, His-tagged E.coli Bovine His 24-166aa
IFNG-8665H Recombinant Human IFNG protein, hFc-Flag-tagged HEK293 Human Fc&Flag 24-166aa
IFNG-88H Human Interferon Gamma (rDNA derived) Reference standard Human Non
IFNG-981H Recombinant Horse IFNG Protein, His-tagged E.coli Horse His Ala25-Gln166
IFNG-99H Active Recombinant Human IFNG Protein E.coli Human Gln24-Gln166
IFNG-P011H Recombinant Human IFNG therapeutic protein (Interferon gamma-1b) E.coli Human Non 146aa

    Background

    IFNG-9.jpg

    Fig1. IFN-γ-producing immune cells and key functions. (Jonathan Thuner, 2023)

    What is IFNG protein?

    IFNG (interferon gamma) gene is a protein coding gene which situated on the long arm of chromosome 12 at locus 12q15. This gene encodes a soluble cytokine that is a member of the type II interferon class. The encoded protein is secreted by cells of both the innate and adaptive immune systems. The active protein is a homodimer that binds to the interferon gamma receptor which triggers a cellular response to viral and microbial infections. The IFNG protein is consisted of 166 amino acids and its molecular mass is approximately 19.3 kDa.

    What is the function of IFNG protein?

    IFNG is an immunomodulatory protein that is primarily released by activated lymphocytes and has a variety of functions. IFN-γ can promote the antiviral ability of host cells, enhance the activity of macrophages, promote the activation of T cells and B cells, and regulate the inflammatory response, which plays an important role in immune response and anti-microbial infection. In addition, IFN-γ can inhibit cell proliferation and regulate immune tolerance and other physiological processes.

    IFNG Related Signaling Pathway

    IFNG is primarily signaling through its receptor IFNGR, and when IFNG binds to the receptor, it induces dimer subunits of the receptor and activates intracellular Janus kinases (JAKs), which leads to phosphorylation of signal transduction and transcriptional activators (STATs), especially STAT1. Phosphorylated STAT1 dimerizes and is transferred into the nucleus to regulate expression of specific genes, including interferon-stimulated response element (ISRE). In addition, IFN-γ also activates other signaling pathways, such as the MAPK and PI3K/Akt pathways, which are closely related to the regulation of cell proliferation, survival, and inflammatory response.

    IFNG Related Diseases

    Diseases associated with this protein include immune deficiency diseases, autoimmune diseases, chronic inflammatory diseases, and certain infectious diseases. Its abnormal function or overactivation can lead to dysregulation of the immune response, triggering a variety of inflammation and diseases, including rheumatoid arthritis, inflammatory bowel disease, systemic lupus erythematosus and others. In the tumor microenvironment, IFNG has a complex bidirectional effect, both promoting anti-tumor immune response and possibly supporting immune evasion and tumor growth. Changes in their levels can affect the development of many cancers.

    IFNG-10.jpg

    Fig2. Immune surveillance and escape from IFN-γ-dependent anticancer activity. (Chiou-Feng Lin, 2017)

    Bioapplications of IFNG

    Using its powerful broad-spectrum activity against viruses, bacteria and parasites, IFNG is used to treat infections including tuberculosis, chronic granulomatosis and other refractory infections. In vaccine development, IFNG can be used as a molecular adjuvant to enhance the immune response triggered by the vaccine and improve the efficiency of antigen presentation, thereby enhancing the efficacy of the vaccine.

    Case Study

    Case study 1: Katelyn J McCann, 2022

    Interferon γ (IFNγ) is an essential and pleiotropic activator of human monocytes, but little is known about the changes in cellular metabolism required for IFNγ-induced activation. We sought to elucidate the mechanisms by which IFNγ reprograms monocyte metabolism to support its immunologic activities. IFNγ increased oxygen consumption rates (OCR) in monocytes, indicative of reactive oxygen species generation by both mitochondria and nicotinamide adenine dinucleotide phosphate (NADPH) oxidase. Transcriptional profiling revealed that this oxidative phenotype was driven by IFNγ-induced reprogramming of NAD+ metabolism, which is dependent on nicotinamide phosphoribosyltransferase (NAMPT)-mediated NAD+ salvage to generate NADH and NADPH for oxidation by mitochondrial complex I and NADPH oxidase, respectively. Interestingly, inhibition of NAMPT in healthy monocytes completely abrogated the IFNγ-induced oxygen consumption, comparable to levels observed in CGD monocytes. These data identify an IFNγ-induced, NAMPT-dependent, NAD+ salvage pathway that is critical for IFNγ activation of human monocytes.

    IFNG-3.jpg

    Fig1. Primary human monocytes were stimulated with media alone, LPS, IFNγ, or LPS plus IFNγ for 24 hours prior to the start of the assay, then ECAR was measured according to the Seahorse Glycolysis Stress Test.

    IFNG-4.jpg
    Fig2. IFNγ-induced increases in OCR are unique to type II interferon and not dependent on total mitochondrial mass, glucose uptake, or substrate-specific catabolism.

    Case study 2: Julian J Freen-van Heeren, 2020

    Long-lasting CD8+ T cell responses are critical in combatting infections and tumors. The pro-inflammatory cytokine IFN-γ is a key effector molecule herein. They researchers recently showed that in murine T cells the production of IFN-γ is tightly regulated through adenylate uridylate-rich elements (AREs) that are located in the 3' untranslated region (UTR) of the Ifng mRNA molecule. Loss of AREs resulted in prolonged cytokine production in activated T cells and boosted anti-tumoral T cell responses. Here, they investigated whether these findings can be translated to primary human T cells.

    Utilizing CRISPR-Cas9 technology, they deleted the ARE region from the IFNG 3' UTR in peripheral blood-derived human T cells. Loss of AREs stabilized the IFNG mRNA in T cells and supported a higher proportion of IFN-γ protein-producing T cells. Importantly, combining MART-1 T cell receptor engineering with ARE-Del gene editing showed that this was also true for antigen-specific activation of T cells. MART-1-specific ARE-Del T cells showed higher percentages of IFN-γ producing T cells in response to MART-1 expressing tumor cells.

    IFNG-5.jpg

    Fig3. Representative concatenated flow cytometry dot plots of IFN-γ production of control and ARE-Del T cells after removal from stimulus for indicated time points.

    IFNG-6.jpg
    Fig4. Representative concatenated flow cytometry dot plots of IFN-γ production of control and ARE-Del T cells after 6, 24, and 48 h of co-culture with MART-1+ and MART-1− tumor cells.

    Quality Guarantee

    High Purity

    High Bioactivity

    IFNG-2.jpg

    Fig2. Activity Data. (IFNG-116H)

    Involved Pathway

    Ifng involved in several pathways and played different roles in them. We selected most pathways Ifng participated on our site, such as Proteasome,Cytokine-cytokine receptor interaction,HIF- signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Ifng were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Malaria SDC1,THBS2,GYPA,HBB-B1,ITGB2,Ccl12,IL1B,TGFB2,TGFB3,MYD88
    Amoebiasis RAB7A,SERPINB2,LAMC1,RAB5B,SERPINB4,LAMB4,PLCB2,RAB7,TLR4,IL1R1
    Antigen processing and presentation HLA-DRB4,RFX5,RFXAP,LGMN,KLRC3,CALR,HSP90AA1,HSPA1B,HLA-F,KIR2DS2
    Systemic lupus erythematosus HIST1H3G,HIST1H2AN,H2AFJ,HLA-DMB,H2AFB1,H2AFY,C6,HIST2H2BB,ELANE,HIST1H2AB
    Toxoplasmosis TGFB1,IKBKG,MAPK12,PIK3CA,LAMB2,PIK3CB,BIRC7,PDPK1,ITGB1,TLR2
    Cytokine-cytokine receptor interaction ACVR1,CSF2RA,IFNA17,IFNA3,CNTF,PDGFA,TGFB1,TNFSF8,TNFSF11,IL17RB
    Inflammatory bowel disease (IBD) RORA,FOXP3,IL21R,RORC,HLA-DMB,IL21,IL12B,HLA-DOA,TLR2,IL23
    Jak-STAT signaling pathway AKT2,HRASB,PIAS4A,BCL2,SOCS7,JAK2A,IL13,AOX3,GFAP,PTPN2B
    Measles IL2RB,AKT2,SH2D1A,IFNA2,IFNGR1,PIK3CD,Fasl,IFNA10,IFNA13,EIF2AK3

    IFNG-7.jpg

    Fig1. Diagram of pathways by which IFNγ regulates cellular NAD+ metabolism. (Katelyn J McCann, 2022)

    IFNG-8.jpg

    Fig2. IFN-γ and IL-17 signaling pathways working together, separately. (Hui Dai, 2020)

    Protein Function

    Ifng has several biochemical functions, for example, cytokine activity,interferon-gamma receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Ifng itself. We selected most functions Ifng had, and list some proteins which have the same functions with Ifng. You can find most of the proteins on our site.

    Function Related Protein
    cytokine activity TGFB1,IL18,TSLP,GDF10B,TNFSF13,OSTN,BMP7B,IL23,IL17A,CMTM1
    interferon-gamma receptor binding DNAJA3,IFNG1-2,IFNG1-1

    Interacting Protein

    Ifng has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Ifng here. Most of them are supplied by our site. Hope this information will be useful for your research of Ifng.

    IFNGR1;b8_vaccw

    Ifng Related Signal Pathway

    Resources

    References

    • Voigt, RM; Keshavarzian, A; et al. HIV-associated mucosal gene expression: region-specific alterations. AIDS 29:537-546(2015).
    • Lv, W; Duan, QL; et al. Expression of B-cell-associated genes in peripheral blood mononuclear cells of patients with symptomatic pulmonary embolism. MOLECULAR MEDICINE REPORTS 11:2299-2305(2015).

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