Active Recombinant Human IFNG Protein (Gln24-Gln166), GMP Grade, Animal-Free
Cat.No. : | IFNG-30HG |
Product Overview : | GMP recombinant human IFN-gamma protein (Gln24-Gln166) with an N-terminal Met was expressed in E. coli, produced in an Animal-Free laboratory and manufactured and tested under cGMP guidelines. |
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Species : | Human |
Source : | E.coli |
Protein Length : | Gln24-Gln166 |
Description : | This gene encodes a soluble cytokine that is a member of the type II interferon class. The encoded protein is secreted by cells of both the innate and adaptive immune systems. The active protein is a homodimer that binds to the interferon gamma receptor which triggers a cellular response to viral and microbial infections. Mutations in this gene are associated with an increased susceptibility to viral, bacterial and parasitic infections and to several autoimmune diseases. |
Bio-activity : | Measured in anti-viral assays using HeLa human cervical epithelial carcinoma cells infected with encephalomyocarditis (EMC) virus. The ED50 for this effect is 0.15-0.75 ng/mL. The specific activity of recombinant human IFN-gamma is >2.0 x 107 IU/mg, which is calibrated against the human IFN-gamma Standard. |
Molecular Mass : | Predicted Molecular Mass: 16.9 kDa SDS-PAGE: 17 kDa, reducing conditions |
N-terminal Sequence Analysis : | Met-Gln24-Asp-Pro-Tyr-Val-Lys-Glu-Ala-Glu |
Endotoxin : | <0.01 EU/ μg of the protein by the LAL method. |
Purity : | >97%, by SDS-PAGE with silver staining, under reducing conditions. |
Storage : | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. A minimum of 12 months when stored at ≤ -20 centigrade as supplied. Refer to lot specific COA for the Use by Date. 1 month, 2 to 8 centigrade under sterile conditions after reconstitution. 3 months, ≤ -20 centigrade under sterile conditions after reconstitution. |
Storage Buffer : | Lyophilized from a 0.2 μm filtered solution in Sodium Succinate, Mannitol and Tween® 80. |
Reconstitution : | Reconstitute at 200 μg/mL in sterile, deionized water. |
Shipping : | The product is shipped with polar packs. |
Gene Name | IFNG interferon, gamma [ Homo sapiens ] |
Official Symbol | IFNG |
Synonyms | IFNG; interferon, gamma; interferon gamma; IFN-gamma; immune interferon; IFG; IFI; |
Gene ID | 3458 |
mRNA Refseq | NM_000619 |
Protein Refseq | NP_000610 |
MIM | 147570 |
UniProt ID | P01579 |
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Not For Human Consumption!
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