CD3E
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Official Full Name
CD3e molecule, epsilon (CD3-TCR complex) -
Overview
The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women. -
Synonyms
CD3E;CD3e molecule, epsilon (CD3-TCR complex);CD3e antigen, epsilon polypeptide (TiT3 complex);T-cell surface glycoprotein CD3 epsilon chain;CD3-epsilon;T-cell surface antigen T3/Leu-4 epsilon chain;T-cell antigen receptor complex, epsilon subunit o;T3E;TCRE;IMD18;T-cell antigen receptor complex,
Recombinant Proteins
- Cynomolgus
- Human
- Mouse
- Canine
- Rat
- Rhesus macaque
- Chicken
- Monkey
- Western lowland gorilla
- Golden hamster
- Pig
- Dog
- Sheep
- HEK293
- Human Cell
- E.coli
- Wheat Germ
- Mammalian Cell
- Mammalian cells
- E. coli
- In Vitro Cell Free System
- CHO
- Yeast
- HEK293T
- HEK293F
- E.coli expression system
- His
- His&Flag
- His&Fc&Flag
- GST
- His&Fc
- His&Avi
- mFc&Flag
- Fc
- C-hFc-Avi
- Strep
- Non
- lIgG2b
- His&Fc&Avi
- Fc&Avi
- N-His&C-Myc
- Myc&DDK
- mFc
- C-Twin-Strep
- His&Strep II
- mFC
- His&GST
Involved Pathway
CD3E involved in several pathways and played different roles in them. We selected most pathways CD3E participated on our site, such as Hematopoietic cell lineage,T cell receptor signaling pathway,Chagas disease (American trypanosomiasis), which may be useful for your reference. Also, other proteins which involved in the same pathway with CD3E were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| HTLV-I infection | FZD2,KAT2B,HLA-DQA1,PRKACG,HLA-DRA,NFATC4,IL2RG,PPP3CA,WNT4,PDGFRB |
| nodeficiency | ZAP70,RFXAP,CD8A,TAP2,CD8B,RFXANK,CD8B1,DCLRE1C,TNFRSF13B,RAG2 |
| Measles | CD209C,IL1B,PIK3R5,Ifna11,CCNE1,MAVS,IL4,IL2RA,IL6,CLEC4M |
| T cell receptor signaling pathway | PIK3CG,NCK2,FYN,PIK3R3,VAV3,NFATC3,PIK3CD,AKT2,CD28,MAP2K1 |
| Hematopoietic cell lineage | KITLG,IL1R2,IL6,CSF3,CD8B1,CD5,CD36,ITGA1,GM13305,IL3 |
| Primary i | DCLRE1C,CD40,TNFRSF13B,BTK,AICDA,CD8B,ZAP70,RFX5,CD19,CD79A |
| Chagas disease (American trypanosomiasis) | IFNB1,PIK3R3,TLR4,MAPK8,TLR6,PPP2CB,GNA15,PIK3CD,CCL3,CD3G |
Protein Function
CD3E has several biochemical functions, for example, SH3 domain binding,T cell receptor binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CD3E itself. We selected most functions CD3E had, and list some proteins which have the same functions with CD3E. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transmembrane signaling receptor activity | TLR10,NRXN2,FCAMR,CLDN3,LYVE1,IGSF6,ENG,OR4C12,TLR4,LGR5 |
| receptor signaling protein activity | FLRT3,DAXX,Siglece,GNAZ,IL4R,DCLK1,NGF,FLRT1,TYROBP,PLCE1 |
| receptor signaling complex scaffold activity | MMS19,DEDD2,LDLRAP1,AXIN1,RGS14,NCK2,CD3G,GRIP1,NUP62,ROPN1B |
| protein binding | AMHR2,ACOT8,RABAC1,TXK,TTC5,KRTAP12-4,STAT5A,PIWIL1,ATP2A2,XAB2 |
| SH3 domain binding | ITM2B,SHANK1,HCLS1,DOCK1,ADAM10,CYBA,INPPL1B,MAPT,WIPF3,PTPN12 |
| protein kinase binding | TRAF6,CD36,AXIN1,TENC1,AKAP5,SYN1,AP2A1,DLG1L,TRAF4,CCNT2B |
| T cell receptor binding | EPS8L1,DOCK2,CD1d1,HLA-A,FYN,CD3G,H2-Q10 |
| protein heterodimerization activity | MTTP,H3F3A,HIST2H2L,HIST1H2BK,Defa-rs7,EFHA1,GTF2A2,ATF2,GRIN1,UGT1A6B |
Interacting Protein
CD3E has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CD3E here. Most of them are supplied by our site. Hope this information will be useful for your research of CD3E.
EPS8L1;NCK1;SYK;ZAP70
Resources
Research Area
ITIM/ITAM Immunoreceptors and Related MoleculesNatural Killer Cells (NK Cells) Markers
gamma delta T Cells
Natural Killer T (NKT) Cells
T Cell Antigen Recognition
T Cell Markers
CD Antigen (T Cell Antigen Recognition)
Th1 Cells
Th17 Cells
Th2 Cells
Th22 Cells
Th9 Cells
Related Services
Related Products
References
- Dickson, MC; Ludbrook, VJ; et al. A model of skin inflammation in humans leads to a rapid and reproducible increase in the interferon response signature: a potential translational model for drug development. INFLAMMATION RESEARCH 64:171-183(2015).
- Chia, LY; Walsh, NC; et al. Isolation and gene expression of haematopoietic-cell-free preparations of highly purified murine osteocytes. BONE 72:34-42(2015).
