APOE
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Official Full Name
apolipoprotein E -
Overview
Apolipoprotein E is essential for the normal catabolism of triglyceride rich lipoprotein constituents. The apolipoprotein E gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in Apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. Mutations in the APOE gene confer susceptibility to Alzheimer's disease by affecting amyloid-beta deposition. -
Synonyms
Apoe;AI255918;apolipoprotein E;apo-E
Recombinant Proteins
- Mouse
- Human
- Rabbit
- Dog
- Rat
- Cattle
- Pig
- Cynomolgus
- HEK293
- E.coli
- S.frugiperda
- N-hFc
- Yeast
- Mammalian Cell
- Mammalian cells
- HEK293T
- Insect Cell
- Human plasma
- Human Plasma
- His
- Non
- His&Avi
- His&Myc
- N-His&Trx
- His&T7
- His&GST
- Trx
- Myc&DDK
- Flag
- His&Myc&SUMO
- His&Myc&B2M
- His&Fc&Avi
- N-His&C-Myc
- Fc
Involved Pathway
APOE involved in several pathways and played different roles in them. We selected most pathways APOE participated on our site, such as Alzheimers disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with APOE were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Alzheimers disease | CALM1,NDUFA8,COX5B,NDUFB5,COX6C,RYR3,NDUFC1,SDHC,NAE1,MME |
Protein Function
APOE has several biochemical functions, for example, antioxidant activity,beta-amyloid binding,cholesterol binding. Some of the functions are cooperated with other proteins, some of the functions could acted by APOE itself. We selected most functions APOE had, and list some proteins which have the same functions with APOE. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| heparin binding | RSPO1,RSPO3,VTN,TENM1,HDGF,GM4980,FGFR2,NELL2,VEGFAB,PDCD5 |
| lipid transporter activity | VTG2,VTG1,SLCO2A1,APOBB.1,VTG7,MTTP,CETP,APOM,APOA4,GM2A |
| tau protein binding | S100B,PPP2R2A,AATF,FKBP4,SNCA,BIN1,SERPINB1A,DYRK1A,HDAC6 |
| lipoprotein particle binding | MAPT,GPIHBP1,CDH13 |
| phosphatidylcholine-sterol O-acyltransferase activator activity | APOEA,APOA4B.1,APOA4,APOA2,APOA5,APOEB,APOA1,APOC1,APOA4A,APOA1A |
| phospholipid binding | PLA2G7,ANXA5,SYTL4,VAMP2,WDFY4,PLA2G4C,RASAL1,FABP1,SERPINB1A,PREX1 |
| low-density lipoprotein particle receptor binding | APOB,MMP13,SACS,DKK1,SNX17,LRPAP1,PCSK9,DNAJA1,MESDC2,CCDC167 |
| very-low-density lipoprotein particle receptor binding | PCSK9,Reln,APOEB,LRPAP1,APOEA |
| antioxidant activity | FABP1,APOM,FAM213AA,PRDX5,SELS,HP,S100A9,PRDX6,MT3,TRP53INP1 |
Interacting Protein
APOE has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with APOE here. Most of them are supplied by our site. Hope this information will be useful for your research of APOE.
HP;TMCC2;LDLR;p27958-pro_0000037570;ECSIT
Resources
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References
- de la Escosura-Muniz, A; Plichta, Z; et al. Alzheimer's disease biomarkers detection in human samples by efficient capturing through porous magnetic microspheres and labelling with electrocatalytic gold nanoparticles. BIOSENSORS & BIOELECTRONICS 67:162-169(2015).
- Hu, JH; Touch, P; et al. Reduction of mouse atherosclerosis by urokinase inhibition or with a limited-spectrum matrix metalloproteinase inhibitor. CARDIOVASCULAR RESEARCH 105:372-382(2015).
