HLA-G
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Official Full Name
major histocompatibility complex, class I, G -
Overview
HLA-G is a nonclassical MHC class I (MHC-Ib) molecule structurally related to MHC class Ia (HLA-A,B, C). There are seven isoforms of this molecule, including membrane bound HLA-G1, -G2, -G3 and -G4 and soluble HLA-G5, -G6, and -G7. HLA-G is primarily expr -
Synonyms
HLA-G;major histocompatibility complex, class I, G;HLA G histocompatibility antigen, class I, G;HLA class I histocompatibility antigen, alpha chain G;b2 microglobulin;HLA G antigen;HLA class I molecule;MHC class I antigen G;HLA-G histocompatibility antigen, class I, G;MHC-G
Recombinant Proteins
- Human
- Cynomolgus
- Rhesus macaque
- HEK293
- E.coli
- Wheat Germ
- HEK293T
- Mammalian cells
- Mamanlian cells
- Insect cells
- E. coli
- Yeast
- In Vitro Cell Free System
- His&Avi
- His&B2M
- His
- GST
- Myc&DDK
- His&SUMO
- Non
- His&Fc&Avi
- Flag
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| HLA-G-312H | Recombinant Human HLA-G Protein, His-Avi-tagged | HEK293 | Human | His&Avi | It contains Gly25-Thr305 (HLA-G), Ile21-Met119 (B2M) and RIIPRHLQL peptide. | |
| HLA-G-4305H | Recombinant Human HLA-G protein, His-B2M-tagged | E.coli | Human | His&B2M | 25-308aa | |
| HLA-G-1241H | Recombinant Human HLA-G Protein | HEK293 | Human | His | 25-338 a.a. | |
| HLA-G-13828H | Recombinant Human HLA-G, GST-tagged | E.coli | Human | GST | 26-308a.a. | |
| HLA-G-27H | Recombinant Human HLA-G protein, GST-tagged | Wheat Germ | Human | GST | 1-338 a.a. | |
| HLA-G-001H | Active Recombinant Human HLA-G Protein, Myc/DDK-tagged | HEK293T | Human | Myc&DDK | ||
| HLA-G-033H | Recombinant Human HLA-G Protein, His-tagged | E.coli | Human | His | 26-308 aa | |
| HLA-G-39H | Recombinant Human HLA-G protein | E.coli | Human | His&SUMO | 25-338 a.a. | |
| HLA-G-501H | Active Recombinant Human HLA-G protein, His-Avi-tagged | HEK293 | Human | His&Avi | It contains Gly25-Thr305(HLA-G),Ile21-Met119(B2M) and RIIPRHLQL peptide. |
|
| HLA-G-505HP | Active Recombinant Human HLA-G complex Protein (tetramer), His-Avi-tagged, PE-Labeled | HEK293 | Human | His&Avi | Gly25-Thr305(HLA-G),Ile21-Met119(B2M) and RIIPRHLQL peptide |
|
| HLA-G-26H | Recombinant Human HLA-G protein, MYC/DDK-tagged | HEK293 | Human | Myc&DDK |
|
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| HLA-G-38H | Recombinant Human HLA-G protein | E.coli | Human | His | 25-338 a.a. |
|
| HLA-G-5493HCL | Recombinant Human HLA 293 Cell Lysate | HEK293 | Human | Non |
|
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| HLA-G-1077H | Recombinant Human HLA-G Protein, His (Fc)-Avi-tagged | HEK293 | Human | His&Fc&Avi |
|
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| HLA-G-1077H-B | Recombinant Human HLA-G Protein Pre-coupled Magnetic Beads | HEK293 | Human |
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| HLA-G-1718HFL | Recombinant Full Length Human HLA-G Protein, C-Flag-tagged | Mammalian cells | Human | Flag | Full L. |
|
| HLA-G-2243H | Recombinant Human HLA-G Protein, His-tagged | E.coli | Human | His | Gly25-Ile308 |
|
| HLA-G-2792HFL | Recombinant Full Length Human HLA-G protein, Flag-tagged | Mamanlian cells | Human | Flag | Full L. |
|
| HLA-G-3036H | Recombinant Human HLA-G protein, His-SUMO-tagged | E.coli | Human | His&SUMO | 25-308aa |
|
| HLA-G-3075H | Recombinant Human HLA-G Protein (Met29-His117), N-GST tagged | E.coli | Human | GST | Met29-His117 |
|
| HLA-G-3322H | Recombinant Human HLA-G protein, His-tagged | Insect cells | Human | His | 25-319aa |
|
| HLA-G-502H | Recombinant Human HLA-G protein(Gly25-Thr305(C66S)), His-Avi-tagged | E. coli | Human | His&Avi | Gly25-Thr305(C66S) |
|
| HLA-G-503C | Recombinant Cynomolgus HLA-G protein, His-Avi-tagged | HEK293 | Cynomolgus | His&Avi | Gly25-Thr305(HLA-G),Ile21-Met119(B2M) and RIIPRHLQL peptide |
|
| HLA-G-503CB | Recombinant Cynomolgus HLA-G protein, His-Avi-tagged, Biotinylated | HEK293 | Cynomolgus | His&Avi | Gly25-Thr305(HLA-G),Ile21-Met119(B2M) and RIIPRHLQL peptide |
|
| HLA-G-503H | Recombinant Human HLA-G protein, His-Avi-tagged, Biotinylated | HEK293 | Human | His&Avi | It contains Gly25-Thr305(HLA-G),Ile21-Met119(B2M) and RIIPRHLQL peptide. |
|
| HLA-G-504H | Recombinant Human HLA-G protein, His-Avi-tagged, Biotinylated | HEK293 | Human | His&Avi | It contains Gly25-Thr305(HLA-G),Ile21-Met119(B2M) and RIIPRHLQL peptide. |
|
| HLA-G-505C | Recombinant Cynomolgus HLA-G Tetramer protein, His-Avi-tagged | HEK293 | Cynomolgus | His&Avi | Gly25-Thr305(HLA-G)&Ile21-Met119(B2M) |
|
| HLA-G-506R | Recombinant Rhesus macaque HLA-G protein, His-Avi-tagged | HEK293 | Rhesus macaque | His&Avi | It contains Gly25-Thr305(HLA-G),Ile21-Met119(B2M) and RIIPRHLQL peptide. |
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| HLA-G-5426H | Recombinant Human HLA-G protein | Yeast | Human | His&SUMO | 25-338 a.a. |
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| HLA-G-651HF | Recombinant Full Length Human HLA-G Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 338 amino acids |
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Involved Pathway
HLA-G involved in several pathways and played different roles in them. We selected most pathways HLA-G participated on our site, such as Endocytosis,Phagosome,Cell adhesion molecules (CAMs), which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-G were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cell adhesion molecules (CAMs) | NLGN2B,CLDNH,ITGB2,CLDN1,CD58,CD80,NRXN2A,CLDN5A,HLA-DPB1,OCLNA |
| Natural killer cell mediated cytotoxicity | IFNA12,KIR3DL2,FCGR3A,NFATC2,IFNB1,KLRC3,IFNA17,PIK3R3,IFNGR2,HLA-B |
| Herpes simplex infection | TAF10,TAF5,MAPK8B,IFNGR1,SRPK1,IL6,SKP1,IRF3,TAF13,IFNGR2 |
| Viral myocarditis | RAC3,ACTB,ITGAL,CASP9,EIF4G2,HLA-DRB4,SGCB,EIF4G3,HLA-A,H2-AA |
| ne thyroid disease | TG,IFNA7,TSHR,IFNA21,HLA-C,HLA-DMB,IFNA5,CD40,HLA-F,HLA-DQB1 |
| Endocytosis | STAMBP,PSD3,SH3GL1,EHD1B,CHMP6B,ARPC5A,ACAP1,PIP5K1AA,TGFBR2,ACAP2 |
| Antigen processing and presentation | CD8A,KIR2DS4,HLA-DPB1,HSPA4,CALR,TAP2,HLA-DMB,CD8B1,HSPA1L,HLA-DRB5 |
| Autoi | IFNA2,CD80,HLA-DMB,HLA-E,HLA-DMA,HLA-A,IFNA4,CD86,PRF1,HLA-DOB |
| Phagosome | MPO,ATP6AP1B,ATPV0E2,EEA1,CD209C,PIK3C3,TUBA8L2,ITGB1B.2,Pla2r1,CLEC4M |
Protein Function
HLA-G has several biochemical functions, for example, peptide antigen binding,protein homodimerization activity,receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-G itself. We selected most functions HLA-G had, and list some proteins which have the same functions with HLA-G. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein homodimerization activity | MID2,ADRA2A,CDA,OXCT1,SLC26A5,ASNSD1,PRLR,LGALS6,PCYT1A,MGLL |
| receptor binding | NXPH3,INHA,HAO2,AGRP,ADIPOQ,F2R,STOML2,UCN2,WNT2BA,ANKRD13C |
| peptide antigen binding | HLA-DRB5,HLA-C,HLA-DQB1,MHC1ZE,MHC1ZFA,MHC1ZDA,BF2,HLA-B,H2-Q10,TAPBP |
Interacting Protein
HLA-G has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-G here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-G.
LILRB1;HLA-A
Resources
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References
- Han, MY; Jiang, YZ; et al. sHLA-G Involved in the Apoptosis of Decidual Natural Killer Cells Following Toxoplasma gondii Infection. INFLAMMATION 37:1718-1727(2014).
- Brugiere, O; Thabut, G; et al. Role of HLA-G as a Predictive Marker of Low Risk of Chronic Rejection in Lung Transplant Recipients: A Clinical Prospective Study. AMERICAN JOURNAL OF TRANSPLANTATION 15:461-471(2015).
