This gene is a member of the EPO/TPO family and encodes a secreted, glycosylated cytokine composed of four alpha helical bundles. The protein is found in the plasma and regulates red cell production by promoting erythroid differentiation and initiating hemoglobin synthesis. This protein also has neuroprotective activity against a variety of potential brain injuries and antiapoptotic functions in several tissue types. [provided by RefSeq, Jul 2008]
EPO involved in several pathways and played different roles in them. We selected most pathways EPO participated on our site, such as Cytokine-cytokine receptor interaction,HIF- signaling pathway,PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with EPO were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
EPO has several biochemical functions, for example, erythropoietin receptor binding,hormone activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EPO itself. We selected most functions EPO had, and list some proteins which have the same functions with EPO. You can find most of the proteins on our site.
EPO has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EPO here. Most of them are supplied by our site. Hope this information will be useful for your research of EPO.
Wiedenmann, T; Ehrhardt, S; et al. Erythropoietin acts as an anti-inflammatory signal on murine mast cells. MOLECULAR IMMUNOLOGY 65:68-76(2015).
Fatemi, MJ; Emami, AH; et al. Effects of Recombinant Human Erythropoietin on Revascularization of Full Thickness Skin Grafts in Rat. IRANIAN RED CRESCENT MEDICAL JOURNAL 16:-(2015).
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