IL11
-
Official Full Name
interleukin 11 -
Overview
The protein encoded by this gene is a member of the gp130 family of cytokines. These cytokines drive the assembly of multisubunit receptor complexes, all of which contain at least one molecule of the transmembrane signaling receptor IL6ST (gp130). This cytokine is shown to stimulate the T-cell-dependent development of immunoglobulin-producing B cells. It is also found to support the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2012] -
Synonyms
IL11;interleukin 11;AGIF;IL-11;interleukin-11;oprelvekin;adipogenesis inhibitory factor
Recombinant Proteins
- Human
- Mouse
- Cynomolgus
- Rat
- Cynomogus
- E.coli
- Human
- P.pastoris
- Insect Cell
- HEK293
- Yeast
- Sf21 Insect Cell
- HEK293F
- Mouse
- Human Cells
- CHO
- Mammalian cells
- Non
- His
- His&T7
- His&MBP&Avi
- Fc
- His&Avi
- N-His-PDI
- His&Myc
Involved Pathway
IL11 involved in several pathways and played different roles in them. We selected most pathways IL11 participated on our site, such as Cytokine-cytokine receptor interaction,Hematopoietic cell lineage,Integrated Pancreatic Cancer Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL11 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Integrated Pancreatic Cancer Pathway | RB1CC1,TFF1,BRF1,PPP1R13L,MAPK4,AGA,RAPGEF3,FKBP3,CASP12,TOP1 |
| Jak-STAT signaling pathway | CRFB4,GFAP,GRB2A,IFNA6,LEPA,PIK3R3,CSF3,PTPN2,IL28A,PRLR |
| Cytokine-cytokine receptor interaction | CTF1,CXCL1,TGFB1A,CCL18,TNFSF9,ACVR2B,TNFRSF8,PRLRA,Il6ra,IL22 |
| Rheumatoid arthritis | TNFSF13,ATP6V0A4,CXCL12,ATP6V0A1,TNFSF13B,TNFSF11,ATP6V1B2,HLA-DQB1,ATP6V0B,IL6 |
| Interleukin-11 Signaling Pathway | BGLAP |
| Hematopoietic cell lineage | IL5,IL4,FCGR1A,ITGA6,IL1R1,CD1B,Il6ra,CD2,FLT3,Kitl |
Protein Function
IL11 has several biochemical functions, for example, cytokine activity,growth factor activity,interleukin-11 receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL11 itself. We selected most functions IL11 had, and list some proteins which have the same functions with IL11. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cytokine activity | THPO,CMTM6,BMP7,TNFSF15,TNFSF13B,IL17D,HMGB1B,Ccl9,GDF5,Gm13290 |
| growth factor activity | MIA,HBEGFB,PPBP,AMBN,BMP8A,EREG,FBRS,DKK1,FGF22,GPR19 |
| protein binding | NXT1,CTSK,C1orf35,TDO2,C10orf28,PPP2R1B,NRAP,MCRS1,EIF3I,GTF3C4 |
Interacting Protein
IL11 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL11 here. Most of them are supplied by our site. Hope this information will be useful for your research of IL11.
MAGEA11;MAGEA11
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References
- Mannam, VKR; Lewis, RE; et al. The fate of renal allografts hinges on responses of the microvascular endothelium. EXPERIMENTAL AND MOLECULAR PATHOLOGY 94:398-411(2013).
- Dams-Kozlowska, H; Gryska, K; et al. A designer hyper interleukin 11 (H11) is a biologically active cytokine. BMC BIOTECHNOLOGY 12:-(2012).
