GPCRs Diseases
- Related links
- Recombinant Proteins
- Native Proteins
- GMP Proteins
- Fluorescent Dyes
- GPCRs Diseases Information
- GPCRs Desensitization
- GPCRs Diseases
- G-protein coupled receptor (GPCR) pathways
- GPCRs Subfamily
- G-protein Signaling
Related Products
Ligands/receptors proteins
Interacting Proteins
Inhibitors/promotors
Substrate
Class A rhodopsin-like
Class B secretin-like
Metabotropic glutamate/pheromone
Class F frizzled (FZD)
Other GPCRs
Studies show that the absence of GPCR function is related to global hypophenotypes of the target tissues; for example, hypothyroidism, hypogonadism, short stature and so on. The following table concludes some diseases related to the absence of GPCR function.
|
The function losing Receptor |
Disease |
| Argine vasopressin receptor 2 | Nephrogenic diabetes insipidus |
| Melanocortin 2 receptor | Familial glucocorticoid deficiency type 1 |
| Luteinizing hormone receptor | Familial hypogonadism Leydig cell hypoplasia (males) Primary amenorrhea (females) |
| Follicle stimulating hormone receptor | Sperm-related hypofertility (males) Ovarian dysgenesis (females) |
| Gonadotropin-releasing hormone receptor | Central hypogonadotropic hypogonadism |
| KiSS 1 receptor | Central hypogonadotropic hypogonadism |
| NK3R (TACR3) | Central hypogonadotropic hypogonadism |
| Prokineticin receptor 2 | Central hypogonadotropic hypogonadism and anosmia (Kallmann syndrome) |
| Relaxin receptor | Cryptorchidism in mice |
| Thyrotropin-releasing hormone receptor | Central hypothyroidism |
| TSH receptor | Euthyroid hyperthyrotropinemia
Congenital hypothyroidism |
| Growth-hormone-releasing hormone |
Short stature (growth hormone deficiency) |
| Ghrelin receptor | Short stature |
| Melanocortin 4 receptor | Extreme obesity |
| Parathyroid hormone and parathyroid related protein | Bloomstrand chondrodysplasia |
| Calcium-sensing receptor | Benign familial hypocalciuric hypercalcemia Neonatal severe primary hyperparathyroidism |