ADCYAP1R1
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Official Full Name
adenylate cyclase activating polypeptide 1 (pituitary) receptor type I -
Overview
This gene encodes type I adenylate cyclase activating polypeptide receptor, which is a membrane-associated protein and shares significant homology with members of the secretin receptor family. This receptor mediates diverse biological actions of adenylate cyclase activating polypeptide 1 and is positively coupled to adenylate cyclase. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Dec 2010] -
Synonyms
ADCYAP1R1;adenylate cyclase activating polypeptide 1 (pituitary) receptor type I;PAC1;PAC1R;PACAPR;PACAPRI;pituitary adenylate cyclase-activating polypeptide type I receptor;PACAP-R1;PACAP receptor 1;PACAP type I receptor;pituitary adenylate cyclase activating polypeptide 1 receptor type I Hiphop
Recombinant Proteins
- Human
- Chicken
- Rat
- Bovine
- Mus musculus
- Wheat Germ
- Mammalian Cell
- HEK293
- Human Cell
- E.coli expression system
- GST
- His
- Fc
- Non
- His&Fc&Avi
Involved Pathway
ADCYAP1R1 involved in several pathways and played different roles in them. We selected most pathways ADCYAP1R1 participated on our site, such as Activation of TRKA receptors,Circadian entrainment,Class B/2 (Secretin family receptors), which may be useful for your reference. Also, other proteins which involved in the same pathway with ADCYAP1R1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Class B/2 (Secretin family receptors) | PTHLH,GNB3A,RAMP2,CALCRL,FZD10,GHRH,CALCA,RAMP3,PTHRP2,CD97 |
| GPCR ligand binding | TAC3,CCR7,EDN1,APLN,RGR,MLN,AGTR2,GPR55,KISS1,CD97 |
| Activation of TRKA receptors | ADORA2A,ADCYAP1,NTF7 |
| GPCRs, Class B Secretin-like | CRHR1,EMR1,CALCRL,EMR2,CRHR2,CD97,LPHN1,ELTD1 |
| Circadian entrainment | CALML3,GNG4,GNB1,GNAI3,MAPK1,GRIN1,KCNJ9,KCNJ3,PRKCB,CALM1 |
| GPCR downstream signaling | OR10A5,RGS14,ANXA1B,TAS2R13,SSTR4,TRH,ITSN1,DRD5,S1PR5B,S1PR3 |
| G alpha (s) signalling events | ADORA2B,ADORA2A,INSL3,RLN2,GHRH,CGA,CRHB,DRD5,GCGB,GPBAR1 |
Protein Function
ADCYAP1R1 has several biochemical functions, for example, ADP-ribosylation factor binding,adenylate cyclase binding,neuropeptide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ADCYAP1R1 itself. We selected most functions ADCYAP1R1 had, and list some proteins which have the same functions with ADCYAP1R1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| receptor activity | GPA33,VMN1R50,CD5,ITGB1B,CRTAM,TNFRSF10B,RAMP3,TNFRSF17,OGFRL2,FKBP3 |
| adenylate cyclase binding | CHRNA7,CALM1,AKAP5,ADRB2,AKAP6,CALM3,CALM2,AKAP12 |
| protein binding | LINGO1,DNAI2,RDBP,COPS7A,GFPT2,GRAP2,MAPK14,BBS13,BCL3,TDRD9 |
| ADP-ribosylation factor binding | GGA2,RAB11FIP4,RAB11FIP4A,GRASP,RAB11FIP3,GGA3,SORL1,ZFP652,RAB11FIP4B |
| vasoactive intestinal polypeptide receptor activity | GHRHRL,VIPR2,ADCYAP1R1A,VIPR1,VIPR1B |
| neuropeptide binding | NPBWR1,GALR1,OPRK1,OPRD1B,SSTR1,OPRD1,OPRD1A,MRGPRB1,NPY8BR,OPRL1 |
Interacting Protein
ADCYAP1R1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADCYAP1R1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADCYAP1R1.
CALM1
Resources
Research Area
Neurotransmitter G Protein-Coupled ReceptorsPeptide Hormone G Protein-Coupled Receptors
Related Services
Related Products
References
- Anderson, ST; Kusters, DHL; et al. Expression of pituitary adenylate cyclase activating polypeptide type 1 receptor (PAC1R) in the ewe hypothalamus: Distribution and colocalization with tyrosine hydroxylase-immunoreactive neurones. JOURNAL OF NEUROENDOCRINOLOGY 17:298-305(2005).
- Joo, KM; Chung, YH; et al. Distribution of vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide receptors (VPAC(1), VPAC(2), and PAC(1) receptor) in the rat brain. JOURNAL OF COMPARATIVE NEUROLOGY 476:388-413(2004).
