CASR
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Official Full Name
calcium-sensing receptor -
Overview
The protein encoded by this gene is a G protein-coupled receptor that is expressed in the parathyroid hormone (PTH)-producing chief cells of the parathyroid gland, and the cells lining the kidney tubule. It senses small changes in circulating calcium concentration and couples this information to intracellular signaling pathways that modify PTH secretion or renal cation handling, thus this protein plays an essential role in maintaining mineral ion homeostasis. Mutations in this gene cause familial hypocalciuric hypercalcemia, familial, isolated hypoparathyroidism, and neonatal severe primary hyperparathyroidism. [provided by RefSeq, Jul 2008] -
Synonyms
CASR;calcium-sensing receptor;CAR;FHH;FIH;HHC;EIG8;HHC1;NSHPT;PCAR1;GPRC2A;HYPOC1;extracellular calcium-sensing receptor;parathyroid Ca(2+)-sensing receptor 1;parathyroid cell calcium-sensing receptor 1
Recombinant Proteins
- Human
- Rat
- Mouse
- Sus scrofa (Pig)
- E.coli
- Wheat Germ
- Mammalian Cell
- HEK293
- Insect Cell
- Mammalian cells
- Yeast
- E.coli expression system
- His
- GST
- Non
- His&Flag
- His&Flag&HA
- His&Fc&Avi
Involved Pathway
CASR involved in several pathways and played different roles in them. We selected most pathways CASR participated on our site, such as Class C/3 (Metabotropic glutamate/pheromone receptors),E-cadherin signaling in keratinocytes,G alpha (i) signalling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with CASR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| G alpha (q) signalling events | GPR65,TAC2,RGS18,ABHD6B,OPN4.1,NMS,EDNRB,HCRT,CHRM1,EDNRA |
| G alpha (i) signalling events | DRD2,OPN1LW,ADORA1,CNR1,NMU,CCR6,DRD4,RGS12,RLN3A,SSTR5 |
| Gastrin-CREB signalling pathway via PKC and MAPK | PROKR1,OPN4,PROKR2,RGS18,FPR-RS3,GPR68,KISS1,DGKG,NTS,TRPC3 |
| GPCR downstream signaling | CRHB,RLN3,LPAR1,ARHGAP4A,PROKR2,CCL19A.2,NET1,RGS10,SSTR1,TAAR1 |
| Class C/3 (Metabotropic glutamate/pheromone receptors) | GPRC6A,TAS2R3,TAS2R7,TAS2R13,TAS2R16 |
| E-cadherin signaling in keratinocytes | FMN1,CTNND1 |
| GPCRs, Class C Metabotropic glutamate, pheromone | GPRC5D,GPRC5C,GPRC5A,GPRC5B |
| GPCR ligand binding | OPN1SW,OPN4A,GCGB,PROKR1,SSTR3,ADRA2B,CHRM1,ADM2,PNOCB,PENKA |
Protein Function
CASR has several biochemical functions, for example, G-protein coupled receptor activity,phosphatidylinositol phospholipase C activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CASR itself. We selected most functions CASR had, and list some proteins which have the same functions with CASR. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| G-protein coupled receptor activity | OPN4XA,MRGPRF,OR10J1,OR12D2,RXFP1,GPR183B,PROKR2,HTR1E,LPAR2A,VIPR2 |
| phosphatidylinositol phospholipase C activity | PLCB2,PLCD1B,PLCD3,PLCB4,PLCB1,PLCD3A,PLCL1,PLCD1A,PLCD1,CHRM5 |
| protein binding | EYA1,C21orf2,GTF2A1,TMEM123,DAZL,COA5,DNAIC2,KIAA1524,RABGAP1,ATXN7 |
Interacting Protein
CASR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CASR here. Most of them are supplied by our site. Hope this information will be useful for your research of CASR.
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References
- Hernandez-Bedolla, MA; Carretero-Ortega, J; et al. Chemotactic and proangiogenic role of calcium sensing receptor is linked to secretion of multiple cytokines and growth factors in breast cancer MDA-MB-231 cells. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH 1853:166-182(2015).
- Marques, P; Santos, R; et al. Chronic Hypocalcemia due to Anti-Calcium Sensing Receptor Antibodies. ACTA MEDICA PORTUGUESA 27:399-402(2014).
