GRM3
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Official Full Name
glutamate receptor, metabotropic 3 -
Overview
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. -
Synonyms
Grm3;glutamate receptor, metabotropic 3;mGluR3;metabotropic glutamate receptor 3;Gprc1c, Mglur3
Recombinant Proteins
- Human
- Rat
- Zebrafish
- Mouse
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- His&GST
- His
- Non
- His&Flag
- His&Fc&Avi
- GST
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| GRM3-1941H | Recombinant Human GRM3 protein, His & GST-tagged | E.coli | Human | His&GST | Asp568~Phe819 |
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| GRM3-2715R | Recombinant Rat GRM3 Protein | Mammalian Cell | Rat | His |
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| GRM3-29609TH | Recombinant Human GRM3 | Wheat Germ | Human | Non | 100 amino acids |
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| GRM3-29610TH | Recombinant Human GRM3 protein | Wheat Germ | Human | Non |
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| GRM3-6856Z | Recombinant Zebrafish GRM3 | Mammalian Cell | Zebrafish | His |
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| GRM3-7286M | Recombinant Mouse GRM3 Protein | Mammalian Cell | Mouse | His |
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| GRM3-5735HCL | Recombinant Human GRM3 293 Cell Lysate | HEK293 | Human | Non |
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| GRM3-1141HFL | Recombinant Human GRM3 protein, His&Flag-tagged | HEK293 | Human | His&Flag | 1-879 aa |
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| GRM3-2369R | Recombinant Rat GRM3 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| GRM3-2369R-B | Recombinant Rat GRM3 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| GRM3-2549H | Recombinant Human GRM3 Protein (Asp568-Phe819), N-GST tagged | E.coli | Human | GST | Asp568-Phe819 |
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| GRM3-3941M | Recombinant Mouse GRM3 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| GRM3-3941M-B | Recombinant Mouse GRM3 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| GRM3-5366H | Recombinant Human GRM3 Protein, GST-tagged | Wheat Germ | Human | GST |
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| GRM3-599HF | Recombinant Full Length Human GRM3 Protein | In Vitro Cell Free System | Human | Full L. 879 amino acids |
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Involved Pathway
GRM3 involved in several pathways and played different roles in them. We selected most pathways GRM3 participated on our site, such as Phospholipase D signaling pathway,Neuroactive ligand-receptor interaction,Glutamatergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with GRM3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Neuroactive ligand-receptor interaction | PTGER1B,CHRNA5,CHRNB1,PTGER2A,GRM5,PTH2R,GH1,NMUR2,MTNR1BB,PRLR |
| Glutamatergic synapse | PLCB4,GRM7,GNG4,MAPK1,GRIA3,GRM8,GRIK2,PLA2G4D,ITPR1,PLD2 |
| Phospholipase D signaling pathway | PIK3R1,PIK3CD,LPAR5,DNM3,PTPN11,CXCR2,SHC4,MS4A2,F2R,PLA2G4C |
| Cocaine addiction | MAOA,NFKB1,PRKACA,SLC6A3,ATF6B,PDYN,CREB3L1,GNAI2,GRIA2,GNAI1 |
Protein Function
GRM3 has several biochemical functions, for example, G-protein coupled receptor activity,calcium channel regulator activity,glutamate receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GRM3 itself. We selected most functions GRM3 had, and list some proteins which have the same functions with GRM3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| G-protein coupled receptor activity | HCAR1-1,EDNRAB,NPFFR1L2,GPR63,HRH1,OLFR149,RHOL,NPFFR1,MRGPRB2,GPR128 |
| calcium channel regulator activity | NPY,CACNA2D1,TSPAN13B,GRM7,TSPAN13,NRXN1,GRM6A,SGK2B,CACNA2D3,TMEM110 |
| group II metabotropic glutamate receptor activity | GRM2A,GRM2 |
| glutamate receptor activity | GRM5,GRM1,GRM6,GRM4,GRIK3,GRID2,GRM8,GRIA1,GRM7,GRIK5 |
Interacting Protein
GRM3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GRM3 here. Most of them are supplied by our site. Hope this information will be useful for your research of GRM3.
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