ADRB1
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Official Full Name
adrenergic, beta-1-, receptor -
Overview
The adrenergic receptors (subtypes alpha 1, alpha 2, beta 1, and beta 2) are a prototypic family of guanine nucleotide binding regulatory protein-coupled receptors that mediate the physiological effects of the hormone epinephrine and the neurotransmitter norepinephrine. Specific polymorphisms in this gene have been shown to affect the resting heart rate and can be involved in heart failure. -
Synonyms
ADRB1;adrenergic, beta-1-, receptor;beta-1 adrenergic receptor;ADR B1;ADRB 1;ADRB1_HUMAN;ADRB1R;Adrenergic beta 1 receptor;B1AR;Beta 1 adrenoceptor;Beta 1 adrenoreceptor;Beta-1 adrenoceptor;Beta-1 adrenoreceptor;BETA1AR;RHR
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Rat
- Zebrafish
- Meriones unguiculatus (Mongolian jird) (Mongolian gerbil)
- Dog
- Sus scrofa (Pig)
- Mus musculus
- Bovine
- Sheep
- Xenopus laevis
- Felis catus
- Meleagris gallopavo (Wild turkey)
- Macaca mulatta
- Sf9 Cells
- Insect Cells
- Mammalian Cells
- Yeast
- HEK293
- E.coli
- His&Flag
- Non
- His
- His&SUMO
- His&Fc&Avi
Involved Pathway
ADRB1 involved in several pathways and played different roles in them. We selected most pathways ADRB1 participated on our site, such as Adrenergic signaling in cardiomyocytes,Adrenoceptors,Amine ligand-binding receptors, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADRB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Calcium Regulation in the Cardiac Cell | GJB5,CX27.5,CASQ2,CHRM2,GJA10,PKIB,PKIG,KCNB1,CX55.5,RGS19 |
| Endocytosis | CHMP5B,DNM2,RAB22A,RAB4A,RLN1,EHD4,VPS26A,VPS37B,VPS4A,SMAD2 |
| Calcium signaling pathway | CACNA1H,RYR3,ERBB3,CD38,HTR7,EDNRA,RYR2,CALM3,SLC25A5,CALM4 |
| Adrenoceptors | ADRa1A,ADRA2A,ADRA1D,ADRA2B,ADRB3,ADRA1B,ADRB2,ADRA2C |
| Amine ligand-binding receptors | DRD5,DRD3,ADRB3,DRD1,HRH3,ADRA1D,CHRM1,CHRM5,TAAR1,DRD4 |
| Adrenergic signaling in cardiomyocytes | BCL2,TNNI3,Adcy4,PPP2R5CB,GNAI2A,PIK3R5,ADCY8,CACNA2D4,CACNG3,TNNC1A |
| Dilated cardiomyopathy | ITGB3,ACTG1,ITGB6,DMD,MYH7,CACNG4,ITGA2,CACNB4,CACNG6,ITGA1 |
| Class A/1 (Rhodopsin-like receptors) | GPR18,PNOC,PROK1,NTS,NMUR1,PROKR1,PRLH,TAC1,OPN4A,DRD5 |
Protein Function
ADRB1 has several biochemical functions, for example, PDZ domain binding,Ras guanyl-nucleotide exchange factor activity,alpha-2A adrenergic receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ADRB1 itself. We selected most functions ADRB1 had, and list some proteins which have the same functions with ADRB1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| alpha-2A adrenergic receptor binding | APLP1,ADRA2C,ADRBK1,UCHL1 |
| Ras guanyl-nucleotide exchange factor activity | RASGRP4,RASGEF1A,RASGEF1B,RASGRP1,RASGRP3,RGL2,RAPGEF5,RAB3A,RASGEF1BA,RAPGEF4 |
| protein heterodimerization activity | BOKB,ADD2,BTBD11,PANX2,CAV1,RELA,EGFR,BCL2A,HIST1H4C,HIST1H4H |
| receptor signaling protein activity | DOK5,NSMAF,DOK2,RGS14A,TIAM2,IL4R,RAF1A,BAG4,GNAZ,IFITM1 |
| beta-adrenergic receptor activity | ADRB3 |
| PDZ domain binding | FZD7,KIDINS220,GRIA1,GRIK2,ACCN3,CXXC4,SSTR2,GRID2,PLEKHA1,PSEN1 |
| norepinephrine binding | ADRB3B,ADRB2,ADRB3A,ADRA2A |
| protein binding | ASUN,GGA2,ZNF473,SWAP70,FLCN,THG1L,PGRMC1,HIST1H2AM,UXT,TBCB |
| epinephrine binding | ADRB2B,ADRB2A,ADRA2C,ADRA2B,ADRB2,ADRB3A,ADRB3B,ADRB3,ADRA2A |
Interacting Protein
ADRB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADRB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADRB1.
MAGI2;MAGI3;Dlg4;GPRASP1;Dlg1;GPRASP2;MAGI1;GOPC;Gipc1;atenolol
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