HTR5A
-
Official Full Name
5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled -
Overview
The neurotransmitter serotonin (5-hydroxytryptamine, 5-HT) has been implicated in a wide range of psychiatric conditions and also has vasoconstrictive and vasodilatory effects. The gene described in this record is a member of 5-hydroxytryptamine (serotonin) receptor family and encodes a multi-pass membrane protein that functions as a receptor for 5-hydroxytryptamine and couples to G-proteins. This protein has been shown to function in part through the regulation of intracellular Ca2+ mobilization. -
Synonyms
HTR5A;5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled;5 hydroxytryptamine (serotonin) receptor 5A;5-hydroxytryptamine receptor 5A;5 HT5A;5-HT-5;5-HT-5A;serotonin receptor 5A;5-HT5A;MGC138226
Recombinant Proteins
- Rhesus macaque
- Human
- Rat
- Zebrafish
- Mouse
- Mus musculus
- Mammalian Cell
- Wheat Germ
- HEK293T
- HEK293
- In Vitro Cell Free System
- E.coli
- E.coli expression system
- His
- Non
- Myc&DDK
- His&Fc&Avi
- GST
Involved Pathway
HTR5A involved in several pathways and played different roles in them. We selected most pathways HTR5A participated on our site, such as Calcium signaling pathway,Neuroactive ligand-receptor interaction,Serotonergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with HTR5A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Calcium signaling pathway | HTR7,BDKRB1,PRKCB,SLC25A4,ERBB4A,CAMK2D,CACNA1B,DRD1,ORAI3,GRIN2D |
| Serotonergic synapse | GNAI3,GABRB2,PRKACG,GNAI2,CYP2C50,GNB4,HTR6,HTR1B,CYP2C70,GNGT1 |
| Neuroactive ligand-receptor interaction | TAAR5,PLG,NPY8AR,FPR1,GALR1,TSPO,P2RY4,TAAR12J,FSHR,GRIN1B |
Protein Function
HTR5A has several biochemical functions, for example, serotonin receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HTR5A itself. We selected most functions HTR5A had, and list some proteins which have the same functions with HTR5A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| serotonin receptor activity | HTR2B,HTR1AA,HTR1B,HTR3A,HTR4,HTR3C,HTR1AB,HTR7,HTR1A,HTR6 |
Interacting Protein
HTR5A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HTR5A here. Most of them are supplied by our site. Hope this information will be useful for your research of HTR5A.
serotonin;lsd-lysergic acid diethylamide
Resources
Related Services
Related Products
References
- Thomsen, WJ; Grottick, AJ; et al. Lorcaserin, a novel selective human 5-Hydroxytryptamine(2C) agonist: In vitro and in vivo pharmacological characterization. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 325:577-587(2008).
- Francken, BJB; Vanhauwe, JFM; et al. Reconstitution of human 5-hydroxytryptamine(5A) receptor-G protein coupling in E-coli and Sf9 cell membranes with membranes from Sf9 cells expressing mammalian G proteins. RECEPTORS & CHANNELS 7:303-318(2001).
