Hrh1
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Official Full Name
histamine receptor H1 -
Overview
Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. This gene was thought to be intronless until recently. The protein encoded by this gene is an integral membrane protein and belongs to the G protein-coupled receptor superfamily. It mediates the contraction of smooth muscles, the increase in capillary permeability due to contraction of terminal venules, the release of catecholamine from adrenal medulla, and neurotransmission in the central nervous system. Multiple alternatively spliced variants, encoding the same protein, have been identified. -
Synonyms
HRH1;histamine receptor H1;histamine H1 receptor;H1R;HisH1;Histamine receptor subclass H1;HH1R;OTTHUMP00000160133;OTTHUMP00000207582;OTTHUMP00000207583;OTTHUMP00000209395;histamine H(1) receptor;histamine receptor, subclass H1;H1-R
Recombinant Proteins
- Guinea Pig
- Human
- Rat
- Zebrafish
- Bovine
- Guinea pig
- Gorilla gorilla gorilla (Western lowland gorilla)
- Pan troglodytes
- Mus musculus
- Pongo Pygmaeus
- Sf9 Insect Cell
- Mammalian Cell
- Wheat Germ
- Insect Cell
- HEK293
- E.coli
- In Vitro Cell Free System
- E.coli expression system
- Non
- His&Flag
- His
- GST
- His&Fc&Avi
- His&Myc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Hrh1-1042G | Recombinant Guinea Pig Histamine Receptor H 1 | Sf9 Insect Cell | Guinea Pig | Non |
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| HRH1-1046H | Recombinant Human Histamine Receptor H 1 | Sf9 Insect Cell | Human | Non |
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| HRH1-27712TH | Recombinant Human HRH1 | Human | His&Flag | Full L. |
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| HRH1-2911R | Recombinant Rat HRH1 Protein | Mammalian Cell | Rat | His |
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| HRH1-3832Z | Recombinant Zebrafish HRH1 | Mammalian Cell | Zebrafish | His |
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| HRH1-5033H | Recombinant Human HRH1 Protein | Wheat Germ | Human | Non |
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| HRH1-5034H | Recombinant Human HRH1 Protein, GST-tagged | Wheat Germ | Human | GST |
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| HRH1-782B | Recombinant Bovine HRH1 Protein, His/FLAG-tagged | Insect Cell | Bovine | His&Flag |
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| Hrh1-784G | Recombinant guinea pig Hrh1 Protein, His/FLAG-tagged | Insect Cell | Guinea pig | His&Flag |
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| HRH1-786H | Recombinant Human HRH1 Protein, Flag-His-tagged | Insect Cell | Human | His&Flag |
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| HRH1-787R | Recombinant Rat RHRH1 Protein, His/FLAG-tagged | Insect Cell | Rat | His&Flag |
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| HRH1-5392HCL | Recombinant Human HRH1 293 Cell Lysate | HEK293 | Human | Non |
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| HRH1-1121HFL | Recombinant Human HRH1 protein, His&Flag-tagged | HEK293 | Human | His&Flag | 1-487 aa |
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| HRH1-2134H | Recombinant Human HRH1 Protein (211-416 aa), His-tagged | E.coli | Human | His | 211-416 aa |
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| HRH1-2565H | Recombinant Human HRH1 Protein (Lys212-Gln416), C-His tagged | E.coli | Human | His | Lys212-Gln416 |
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| HRH1-2566R | Recombinant Rat HRH1 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| HRH1-2566R-B | Recombinant Rat HRH1 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| HRH1-3663HF | Recombinant Full Length Human HRH1 Protein | In Vitro Cell Free System | Human | Full L. 644 amino acids |
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| HRH1-3664HF | Recombinant Full Length Human HRH1 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 487 amino acids |
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| Hrh1-732R | Recombinant Rat Hrh1 protein, His&Myc-tagged | E.coli | Rat | His&Myc | 211-415a.a. |
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| RFL12384GF | Recombinant Full Length Gorilla Gorilla Gorilla Histamine H1 Receptor(Hrh1) Protein, His-Tagged | E.coli expression system | Gorilla gorilla gorilla (Western lowland gorilla) | His | Full L. Full Length (1-487) |
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| RFL23053PF | Recombinant Full Length Pan Troglodytes Histamine H1 Receptor(Hrh1) Protein, His-Tagged | E.coli expression system | Pan troglodytes | His | Full L. Full Length (1-487) |
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| RFL2649RF | Recombinant Full Length Rat Histamine H1 Receptor(Hrh1) Protein, His-Tagged | E.coli expression system | Rat | His | Full L. Full Length (1-486) |
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| RFL33116HF | Recombinant Full Length Human Histamine H1 Receptor(Hrh1) Protein, His-Tagged | E.coli expression system | Human | His | Full L. Full Length (1-487) |
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| RFL34521CF | Recombinant Full Length Guinea Pig Histamine H1 Receptor(Hrh1) Protein, His-Tagged | E.coli expression system | Guinea pig | His | Full L. Full Length (1-488) |
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| RFL4498MF | Recombinant Full Length Mouse Histamine H1 Receptor(Hrh1) Protein, His-Tagged | E.coli expression system | Mus musculus | His | Full L. Full Length (1-488) |
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| RFL4849BF | Recombinant Full Length Bovine Histamine H1 Receptor(Hrh1) Protein, His-Tagged | E.coli expression system | Bovine | His | Full L. Full Length (1-491) |
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| RFL7763PF | Recombinant Full Length Pongo Pygmaeus Histamine H1 Receptor(Hrh1) Protein, His-Tagged | E.coli expression system | Pongo Pygmaeus | His | Full L. Full Length (1-487) |
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Involved Pathway
Hrh1 involved in several pathways and played different roles in them. We selected most pathways Hrh1 participated on our site, such as Calcium signaling pathway,Neuroactive ligand-receptor interaction,Inflammatory mediator regulation of TRP channels, which may be useful for your reference. Also, other proteins which involved in the same pathway with Hrh1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Neuroactive ligand-receptor interaction | HTR1B,GABRE,NPFFR1L2,NTSR2,NPBWR1,P2RY6,CHRM5B,VIPR1,DRD1B,GABRB3 |
| Calcium signaling pathway | CACNA1BA,GNA15,PPP3CB,ITPR1,SLC8A1B,SLC8A4A,CCKAR,PPIFB,MYLK,TNNC1 |
| Inflammatory mediator regulation of TRP channels | CYP2C39,PLCB4,PLCB2,PIK3R3,MAPK13,PLA2G4C,ACCN5,ALOX12,CALM4,PLA2G4D |
Protein Function
Hrh1 has several biochemical functions, for example, G-protein coupled receptor activity,histamine binding,histamine receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Hrh1 itself. We selected most functions Hrh1 had, and list some proteins which have the same functions with Hrh1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| histamine binding | HRH3,HRH4 |
| histamine receptor activity | HRH3,HRH2,HTR6,HRH4 |
| G-protein coupled receptor activity | GPR26,COR1,NMUR1,OR51B2,TAS2R104,OR2L5,TAAR19P,PTGER1A,OLFR18,GPR34A |
Interacting Protein
Hrh1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Hrh1 here. Most of them are supplied by our site. Hope this information will be useful for your research of Hrh1.
pyrilamine;IL6
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References
- Pagotto, RM; Pereyra, EN; et al. Histamine inhibits adrenocortical cell proliferation but does not affect steroidogenesis. JOURNAL OF ENDOCRINOLOGY 221:15-28(2014).
- Costanza, M; Di Dario, M; et al. Gene expression analysis of histamine receptors in peripheral blood mononuclear cells from individuals with clinically-isolated syndrome and different stages of multiple sclerosis. JOURNAL OF NEUROIMMUNOLOGY 277:186-188(2014).
