Hrh1
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Official Full Name
histamine receptor H1 -
Overview
Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. This gene was thought to be intronless until recently. The protein encoded by this gene is an integral membrane protein and belongs to the G protein-coupled receptor superfamily. It mediates the contraction of smooth muscles, the increase in capillary permeability due to contraction of terminal venules, the release of catecholamine from adrenal medulla, and neurotransmission in the central nervous system. Multiple alternatively spliced variants, encoding the same protein, have been identified. -
Synonyms
HRH1;histamine receptor H1;histamine H1 receptor;H1R;HisH1;Histamine receptor subclass H1;HH1R;OTTHUMP00000160133;OTTHUMP00000207582;OTTHUMP00000207583;OTTHUMP00000209395;histamine H(1) receptor;histamine receptor, subclass H1;H1-R
Recombinant Proteins
- Guinea Pig
- Human
- Rat
- Zebrafish
- Bovine
- Guinea pig
- Gorilla gorilla gorilla (Western lowland gorilla)
- Pan troglodytes
- Mus musculus
- Pongo Pygmaeus
- Sf9 Cells
- Mammalian Cells
- Wheat Germ
- Insect Cells
- HEK293
- E.coli
- In Vitro Cell Free System
- Non
- Flag
- His
- GST
- Avi
- Fc
- Myc
Involved Pathway
Hrh1 involved in several pathways and played different roles in them. We selected most pathways Hrh1 participated on our site, such as Calcium signaling pathway,Neuroactive ligand-receptor interaction,Inflammatory mediator regulation of TRP channels, which may be useful for your reference. Also, other proteins which involved in the same pathway with Hrh1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Neuroactive ligand-receptor interaction | PTGIR,RXFP1,GNRHR4,TAAR14A,NR3C1,GLRA1,LPAR6A,GABBR2,TAAR14I,DRD2A |
| Inflammatory mediator regulation of TRP channels | PRKCG,TRPM8,PLCG2,CALM1,CAMK2G,PLA2G4F,HTR2B,PRKACB,CALM2,Adcy4 |
| Calcium signaling pathway | CALM3B,CAMK2G1,ITPR1,TNNC1,PLCZ1,TRHR,MLCK2,ADCY2B,CALML5,CAMK2B |
Protein Function
Hrh1 has several biochemical functions, for example, G-protein coupled receptor activity,histamine binding,histamine receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Hrh1 itself. We selected most functions Hrh1 had, and list some proteins which have the same functions with Hrh1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| histamine receptor activity | HRH3,HRH2,HTR6,HRH4 |
| histamine binding | HRH4,HRH3 |
| G-protein coupled receptor activity | ADRA1BB,OLFR1002,GPR132,NPY,ADCYAP1R1A,P2RY6,GPR31,NMUR1,CELSR2,OR5V1 |
Interacting Protein
Hrh1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Hrh1 here. Most of them are supplied by our site. Hope this information will be useful for your research of Hrh1.
pyrilamine;IL6
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References
- Pagotto, RM; Pereyra, EN; et al. Histamine inhibits adrenocortical cell proliferation but does not affect steroidogenesis. JOURNAL OF ENDOCRINOLOGY 221:15-28(2014).
- Costanza, M; Di Dario, M; et al. Gene expression analysis of histamine receptors in peripheral blood mononuclear cells from individuals with clinically-isolated syndrome and different stages of multiple sclerosis. JOURNAL OF NEUROIMMUNOLOGY 277:186-188(2014).
