MC4R
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Official Full Name
melanocortin 4 receptor -
Overview
The protein encoded by this gene is a membrane-bound receptor and member of the melanocortin receptor family. The encoded protein interacts with adrenocorticotropic and MSH hormones and is mediated by G proteins. This is an intronless gene. Defects in this gene are a cause of autosomal dominant obesity. -
Synonyms
MC4R;melanocortin 4 receptor;melanocortin receptor 4;MC4-R;MGC126851;MGC138197
Recombinant Proteins
- Human
- Chicken
- Rat
- Zebrafish
- Mouse
- Macaca fascicularis
- Vulpes vulpes (Red fox)
- Bovine
- Mus musculus
- Sus scrofa (Pig)
- HEK293
- Wheat Germ
- Mammalian Cell
- In vitro E. coli expression system
- E.coli
- HEK293T
- E.coli expression system
- Non
- His
- His&Flag
- N-His-SUMO
- His&Fc&Avi
- Myc&DDK
Involved Pathway
MC4R involved in several pathways and played different roles in them. We selected most pathways MC4R participated on our site, such as Neuroactive ligand-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with MC4R were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Neuroactive ligand-receptor interaction | CHRNA10,SCTR,GNRHR,FSHB,GRIA1B,TAAR2,MCHR2,PTGER3,GABRA3,GRIA4B |
Protein Function
MC4R has several biochemical functions, for example, melanocortin receptor activity,melanocyte-stimulating hormone receptor activity,neuropeptide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MC4R itself. We selected most functions MC4R had, and list some proteins which have the same functions with MC4R. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| melanocyte-stimulating hormone receptor activity | MC1R,MC3R |
| protein binding | DCC,ISCU,MAPT,KLHL20,PRDX4,C22orf23,LTBP2,IRS4,HDAC10,GTF2H2C_2 |
| peptide hormone binding | OXTR,RXFP2,PTH1RA,GHSR,GALR1,GALR3,AGTR1A,SLC40A1,MAS1,GALR2 |
| melanocortin receptor activity | MC2R,MC5RA,MC3R,MC1R,MC5R,MC5RB |
| ubiquitin protein ligase binding | TXNIP,YWHAE,ATXN3,HDAC6,H2-AB1,TP53,PRKACB,TSG101,CASP10,HSPD1 |
| neuropeptide binding | NPBWR2,MC3R,OPRL1,MRGPRB1,OPRM1,NPY8AR,OPRD1B,NPY8BR,PTGDR2,NPBWR1 |
Interacting Protein
MC4R has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MC4R here. Most of them are supplied by our site. Hope this information will be useful for your research of MC4R.
MRAP;MRAP2;IL1RAP
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References
- Shelkar, GP; Kale, AD; et al. Alpha-melanocyte stimulating hormone modulates ethanol self-administration in posterior ventral tegmental area through melanocortin-4 receptors. ADDICTION BIOLOGY 20:302-315(2015).
- Benjamins, JA; Nedelkoska, L; et al. Adrenocorticotropin Hormone 1-39 Promotes Proliferation and Differentiation of Oligodendroglial Progenitor Cells and Protects From Excitotoxic and Inflammation-Related Damage. JOURNAL OF NEUROSCIENCE RESEARCH 92:1243-1251(2014).
