HTR2C
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Official Full Name
5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled -
Overview
Serotonin (5-hydroxytryptamine, 5-HT), a neurotransmitter, elicits a wide array of physiological effects by binding to several receptor subtypes, including the 5-HT2 family of seven-transmembrane-spanning, G-protein-coupled receptors, which activate phospholipase C and D signaling pathways. This gene encodes the 2C subtype of serotonin receptor and its mRNA is subject to multiple RNA editing events, where genomically encoded adenosine residues are converted to inosines. RNA editing is predicted to alter amino acids within the second intracellular loop of the 5-HT2C receptor and generate receptor isoforms that differ in their ability to interact with G proteins and the activation of phospholipase C and D signaling cascades, thus modulating serotonergic neurotransmission in the central nervous system. Studies in rodents show altered patterns of RNA editing in response to drug treatments and stressful situations. -
Synonyms
HTR2C;5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled;5 hydroxytryptamine (serotonin) receptor 2C , HTR1C;5-hydroxytryptamine receptor 2C;5 HT2C;5-HT1C;5-HT-1C;5-HT-2C;serotonin receptor 2C;serotonin 5-HT-2C receptor;5-hydroxytryp
Recombinant Proteins
- Human
- Rat
- Mouse
- Rhesus macaque
- Pan troglodytes
- Mus musculus
- Dog
- Wheat Germ
- Mammalian Cell
- E. coli
- HEK293
- E.coli expression system
- Non
- His
- His&Flag
- His&Fc&Avi
- GST
Involved Pathway
HTR2C involved in several pathways and played different roles in them. We selected most pathways HTR2C participated on our site, such as Calcium signaling pathway,Neuroactive ligand-receptor interaction,Gap junction, which may be useful for your reference. Also, other proteins which involved in the same pathway with HTR2C were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Serotonergic synapse | GNG11,ARAF,HRAS,NRAS,PRKCA,RAF1,GABRB1,ALOX12B,TRPC1,ALOX5 |
| Calcium signaling pathway | PPIF,CAMK4,PHKA1,LTB4R2,PHKG2,Adcy4,DRD1A,NTSR1,CACNA1H,GNA15.4 |
| Inflammatory mediator regulation of TRP channels | TRPV2,CALM2,CYP4A12A,CYP2J5,PRKCE,PTGER4,ACCN3,PTGER2,CYP2C37,PRKCA |
| Gap junction | CDK1,MAP2K1,ADCY1A,MAP2K5,PDGFAB,PLCB4,GNA11,DRD2L,TUBA8L,TUBB2B |
| Neuroactive ligand-receptor interaction | NPY7R,P2RY14,GRIN2A,GPR156,LEPB,GH1,PTGIR,P2RX4B,TAAR12H,SSTR4 |
Protein Function
HTR2C has several biochemical functions, for example, 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding,Gq/11-coupled serotonin receptor activity,drug binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HTR2C itself. We selected most functions HTR2C had, and list some proteins which have the same functions with HTR2C. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| drug binding | SFRP1,RARB,HTR2B,CNR1,SIGMAR1,PDE2A,PDE10A,SRP54,FOLR1,SETD6 |
| serotonin receptor activity | HTR1AA,HTR1E,HTR2CL1,HTR1D,HTR2B,HTR3A,HTR1F,HTR5A,HTR1AB,HTR6 |
| 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding | HTR2A |
| serotonin binding | HTR1B,HTR2B,HTR3A,HTR1F,HTR2A,HTR1E,MAOA |
Interacting Protein
HTR2C has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HTR2C here. Most of them are supplied by our site. Hope this information will be useful for your research of HTR2C.
MPDZ;mesulergine;Arrb2;Mpdz
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