CCL26
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Official Full Name
chemokine (C-C motif) ligand 26 -
Overview
This gene is one of two Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 7. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for normal peripheral blood eosinophils and basophils. The product of this gene is one of three related chemokines that specifically activate chemokine receptor CCR3. This chemokine may contribute to the eosinophil accumulation in atopic diseases. -
Synonyms
CCL26;chemokine (C-C motif) ligand 26;SCYA26, small inducible cytokine subfamily A (Cys Cys), member 26;C-C motif chemokine 26;CC chemokine IMAC;chemokine N1;eotaxin 3;IMAC;macrophage inflammatory protein 4 alpha;MIP 4a;MIP 4alpha;small inducible cytokine A26;thymic stroma chemokine 1;TSC 1;CCL 26;CCL26_HUMAN;Chemokine (C C motif) ligand 26;Eotaxin-3;macrophage inflammatory protein 4-alpha;MIP-4-alpha;MIP4a;MIP4alpha;SCYA 26;SCYA26;Small inducible cytokine subfamily A (Cys Cys) member 26;Small inducible cytokine subfamily A member 26;Small-inducible cytokine A26;Thymic stroma chemokine-1;TSC-1;TSC1;OTTHUMP00000160954;OTTHUMP00000210227;small inducible c;MIP-4a;MIP-4alpha
Recombinant Proteins
- Human
- E.coli
- Wheat Germ
- HEK293
- Insect Cells
- Human Cells
- In Vitro Cell Free System
- GST
- His
- Non
- His&GST
Involved Pathway
CCL26 involved in several pathways and played different roles in them. We selected most pathways CCL26 participated on our site, such as Chemokine signaling pathway,Cytokine-cytokine receptor interaction,IL4-mediated signaling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with CCL26 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Chemokine signaling pathway | CCL28,CCL19,CCR1,MAPK1,PLCB2,RAC1,PIK3CG,CXCL2,STAT3,LOC100033925 |
| IL4-mediated signaling events | NIPAL1,MYBL1,DOK2,RETNLB,IgG3,MYB,EGR2,IRF4,TFF3,PARP14 |
| Cytokine-cytokine receptor interaction | CD70,XCL2,INHBE,IL15RA,TNFRSF19,CXCR3.1,CX3CL1,BMPR1B,INHBC,IL12B |
Protein Function
CCL26 has several biochemical functions, for example, CCR chemokine receptor binding,chemokine activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CCL26 itself. We selected most functions CCL26 had, and list some proteins which have the same functions with CCL26. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| chemokine activity | CXCL19,CCL34A.3,Cxcl15,CCL19,CCL19B,CCL17,CCL2,CCL22,CXCL8B.3,CCL18 |
| CCR chemokine receptor binding | CCL16,CCL21,CCL20A.3,CCL22,CCL33.3,CCRL2,CCL18,CCL19,XCL1,CCL3L3 |
Interacting Protein
CCL26 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCL26 here. Most of them are supplied by our site. Hope this information will be useful for your research of CCL26.
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References
- Sugaya, M; et al. Chemokines and Skin Diseases. ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS 63:109-115(2015).
- Huang, XS; Gruner, B; et al. Distinctive cytokine, chemokine, and antibody responses in Echinococcus multilocularis-infected patients with cured, stable, or progressive disease. MEDICAL MICROBIOLOGY AND IMMUNOLOGY 203:185-193(2014).
