EDNRB

  • Official Full Name

    endothelin receptor type B

  • Overview

    The protein encoded by this gene is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in the endothelin receptor type B gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

  • Synonyms

    EDNRB;endothelin receptor type B;ETB;ET-B;ETBR;ETRB;HSCR;WS4A;ABCDS;ET-BR;HSCR2;endothelin B receptor;endothelin receptor non-selective type

Recombinant Proteins

  • Human
  • Chicken
  • Rat
  • Mouse
  • Mus musculus
  • Coturnix japonica
  • Sus scrofa (Pig)
  • Bovine
  • Oryctolagus cuniculus (Rabbit)
  • Dog
  • Horse
  • E.coli
  • Mammalian Cell
  • Human Cell
  • Wheat Germ
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • In vitro E. coli expression system
  • E.coli expression system
  • His
  • Fc
  • Non
  • GST
  • Myc&DDK
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
EDNRB-12286H Recombinant Human EDNRB, His-tagged E.coli Human His 27-99a.a.
EDNRB-1068C Recombinant Chicken EDNRB Mammalian Cell Chicken His
EDNRB-2012R Recombinant Rat EDNRB Protein Mammalian Cell Rat His
EDNRB-272H Recombinant Human EDNRB, Fc-tagged Human Cell Human Fc Met1-Lys101
EDNRB-28559TH Recombinant Human EDNRB Wheat Germ Human Non 75 amino acids
EDNRB-3061H Recombinant Human EDNRB Protein, GST-tagged Wheat Germ Human GST
EDNRB-4995M Recombinant Mouse EDNRB Protein Mammalian Cell Mouse His
EDNRB-687H Recombinant Human EDNRB protein(Met1-Lys101), His-tagged HEK293 Human His Met1-Lys101
EDNRB-001HCL Recombinant Human EDNRB cell lysate Human Cell Human Non
EDNRB-1209H Recombinant Human EDNRB Protein, MYC/DDK-tagged HEK293 Human Myc&DDK
EDNRB-1376H Recombinant Human EDNRB Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Human Myc&DDK
EDNRB-1669R Recombinant Rat EDNRB Protein, His (Fc)-Avi-tagged HEK293 Rat His&Fc&Avi
EDNRB-1669R-B Recombinant Rat EDNRB Protein Pre-coupled Magnetic Beads HEK293 Rat
EDNRB-2642M Recombinant Mouse EDNRB Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
EDNRB-2642M-B Recombinant Mouse EDNRB Protein Pre-coupled Magnetic Beads HEK293 Mouse
Ednrb-2730M Recombinant Mouse Ednrb Protein, Myc/DDK-tagged HEK293T Mouse Myc&DDK
EDNRB-284H Active Recombinant Fluorescent Human EDNRB Full Length Transmembrane protein(VLPs) HEK293 Human Non Full L. Glu 27 - Ser 442
EDNRB-4203HF Recombinant Full Length Human EDNRB Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 442 amino acids
EDNRB-9103H Active Recombinant Human EDNRB Full Length Transmembrane protein, His-tagged In vitro E. coli expression system Human His Full L. 27-442aa
RFL10102MF Recombinant Full Length Mouse Endothelin B Receptor(Ednrb) Protein, His-Tagged E.coli expression system Mus musculus His Full L. Full Length of Mature Protein (27-442)
RFL14596HF Recombinant Full Length Human Endothelin B Receptor(Ednrb) (Active) Protein, His-Tagged E.coli expression system Human His Full L. Full Length of Mature Protein (27-442aa)
RFL19386RF Recombinant Full Length Rat Endothelin B Receptor(Ednrb) Protein, His-Tagged E.coli expression system Rat His Full L. Full Length of Mature Protein (27-442)
RFL21402CF Recombinant Full Length Coturnix Coturnix Japonica Endothelin B Receptor(Ednrb) Protein, His-Tagged E.coli expression system Coturnix japonica His Full L. Full Length (1-347)
RFL22181SF Recombinant Full Length Pig Endothelin B Receptor(Ednrb) Protein, His-Tagged E.coli expression system Sus scrofa (Pig) His Full L. Full Length of Mature Protein (27-443)
RFL23628BF Recombinant Full Length Bovine Endothelin B Receptor(Ednrb) Protein, His-Tagged E.coli expression system Bovine His Full L. Full Length of Mature Protein (27-441)
RFL26513OF Recombinant Full Length Rabbit Endothelin B Receptor(Ednrb) Protein, His-Tagged E.coli expression system Oryctolagus cuniculus (Rabbit) His Full L. Full Length of Mature Protein (27-441)
RFL6232CF Recombinant Full Length Dog Endothelin B Receptor(Ednrb) Protein, His-Tagged E.coli expression system Dog His Full L. Full Length of Mature Protein (27-442)
RFL985EF Recombinant Full Length Horse Endothelin B Receptor(Ednrb) Protein, His-Tagged E.coli expression system Horse His Full L. Full Length of Mature Protein (27-443)

    Involved Pathway

    EDNRB involved in several pathways and played different roles in them. We selected most pathways EDNRB participated on our site, such as Arf6 trafficking events,Calcium signaling pathway,Class A/1 (Rhodopsin-like receptors), which may be useful for your reference. Also, other proteins which involved in the same pathway with EDNRB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Class A/1 (Rhodopsin-like receptors) PTGDR2,GAL,CCK,EDN3,AGTR1,ADRa1A,GPR132,NPB,PENKB,CYSLTR1
    GPCR downstream signaling OPN4A,OR52J3,OR10A5,ADCYAP1R1,PPY,OXGR1A.1,CCK,ABHD6B,CCR7,RHOB
    Calcium signaling pathway SLC25A31,TACR1B,STIM1A,ITPKB,PHKA1,SLC25A6,RYR3,SLC8A2,LTB4R2,NOS2B
    G alpha (q) signalling events ANXA1A,ABHD6B,PRKCHB,LPAR1,AGTR1,NMUR1,OPN4,QRFP,NMU,PROKR1
    Arf6 trafficking events EXOC6,SCAMP2,EXOC5,EXOC1,CLTC,DNM2,JUP,SPAG9,ADRB2,CTNNA1
    Endothelins EDN2,EDNRA,EDN1,COL1A2,CYSLTR1,EDN3,COL3A1
    GPCR ligand binding OPN4A,EDNRAB,SST1.1,GPR4,GPR55A,OPN5,CGA,ADM2,GPRC6A,CALCB
    Endothelin CNN1,EDNRA,RAMP1,CALCRL,CALCA,MYL1,ECE1,EDN1

    Protein Function

    EDNRB has several biochemical functions, for example, endothelin receptor activity,peptide hormone binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EDNRB itself. We selected most functions EDNRB had, and list some proteins which have the same functions with EDNRB. You can find most of the proteins on our site.

    Function Related Protein
    endothelin receptor activity EDNRAA,EDNRAB,EDNRBA,EDNRA
    peptide hormone binding NPR3,GALR1,MAS1,GALR3,CRHR2,GHRHR,AGTR1A,GCGR,HCRTR2,GHR
    protein binding PRC1,RBM10,KRT25,S100A7,MTSS1,CD274,TRIB3,CRYAB,EIF1AY,CUL5

    Interacting Protein

    EDNRB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EDNRB here. Most of them are supplied by our site. Hope this information will be useful for your research of EDNRB.

    EDN1

    Resources

    Gene Families

    What is GPCR

    Research Area

    Peptide Receptors on VSMC
    Inflammatory Mediators

    References

    • Wang, C; Wang, HY; et al. Genome-wide analysis reveals artificial selection on coat colour and reproductive traits in Chinese domestic pigs. MOLECULAR ECOLOGY RESOURCES 15:414-424(2015).
    • Moore, SW; Zaahl, M; et al. Clinical and genetic correlations of familial Hirschsprung's disease. JOURNAL OF PEDIATRIC SURGERY 50:285-288(2015).

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