GHSR
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Official Full Name
growth hormone secretagogue receptor -
Overview
This gene encodes a member of the G-protein coupled receptor family. The encoded protein may play a role in energy homeostasis and regulation of body weight. Two identified transcript variants are expressed in several tissues and are evolutionary conserved in fish and swine. One transcript, 1a, excises an intron and encodes the functional protein; this protein is the receptor for the Ghrelin ligand and defines a neuroendocrine pathway for growth hormone release. The second transcript (1b) retains the intron and does not function as a receptor for Ghrelin; however, it may function to attenuate activity of isoform 1a. Mutations in this gene are associated with autosomal idiopathic short stature. -
Synonyms
GHSR;growth hormone secretagogue receptor;growth hormone secretagogue receptor type 1;GH releasing peptide receptor;GH-releasing peptide receptor;Ghrelin receptor;GHRP;GHRPR;GHS-R;GHSR_HUMAN;Growth hormone secretagogue receptor 1;growth hormone secretatgogue receptor
Recombinant Proteins
- Rat
- Human
- Chicken
- Mus musculus
- Oryctolagus cuniculus (Rabbit)
- Sus scrofa (Pig)
- Mustela putorius furo (European domestic ferret) (Mustela furo)
- Mammalian Cells
- Wheat Germ
- HEK293
- E.coli
- In Vitro Cell Free System
- His
- Non
- Flag
- His&GST
- His&Fc&Avi
- GST
Involved Pathway
GHSR involved in several pathways and played different roles in them. We selected most pathways GHSR participated on our site, such as cAMP signaling pathway,Neuroactive ligand-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with GHSR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| cAMP signaling pathway | GABBR1,MC2R,HTR1A,PIK3CB,RRAS2,FSHR,GRIN2D,PTGER2,PTGER3,PDE4A |
| Neuroactive ligand-receptor interaction | P2RY4,S1PR5,AGTR1A,VIPR1,APLNRB,DRD1A,PRLHR,P2RX3B,F2,HTR1D |
Protein Function
GHSR has several biochemical functions, for example, G-protein coupled receptor activity,growth hormone secretagogue receptor activity,growth hormone-releasing hormone receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GHSR itself. We selected most functions GHSR had, and list some proteins which have the same functions with GHSR. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| peptide hormone binding | SLC40A1,OXTR,ECE1,AGTR1A,PRLR,NPR1,RXFP2,GALR2,ANXA5,MAS1 |
| G-protein coupled receptor activity | LPAR5B,ADORA2AB,TPRA1,DRD1A,MRGPRX1,EMR1,TAS2R130,GPR124,PROKR1A,TAAR4 |
| growth hormone-releasing hormone receptor activity | MLNR,GHSRA,GHRHRA,GHRHR |
Interacting Protein
GHSR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GHSR here. Most of them are supplied by our site. Hope this information will be useful for your research of GHSR.
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References
- Mani, BK; Walker, AK; et al. Neuroanatomical Characterization of a Growth Hormone Secretagogue Receptor-Green Fluorescent Protein Reporter Mouse. JOURNAL OF COMPARATIVE NEUROLOGY 522:3644-3666(2014).
- Niarami, MD; Masoudi, AA; et al. ASSOCIATION OF SINGLE NUCLEOTIDE POLYMORPHISM OF GHSR AND TGFB2 GENES WITH GROWTH AND BODY COMPOSITION TRAITS IN SIRE AND DAM LINES OF A BROILER CHICKEN. ANIMAL BIOTECHNOLOGY 25:13-22(2014).
