HTR2B

  • Official Full Name

    5-hydroxytryptamine (serotonin) receptor 2B

  • Overview

    This gene encodes one of the several different receptors for 5-hydroxytryptamine (serotonin) that belongs to the G-protein coupled receptor 1 family. Serotonin is a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. Serotonin receptors mediate many of the central and peripheral physiologic functions of serotonin, including regulation of cardiovascular functions and impulsive behavior. Population and family-based analyses of a minor allele (glutamine-to-stop substitution, designated Q20*) which blocks expression of this protein, and knockout studies in mice, suggest a role for this gene in impulsivity. However, other factors, such as elevated testosterone levels, may also be involved.

  • Synonyms

    HTR2B;5-hydroxytryptamine (serotonin) receptor 2B;5-hydroxytryptamine receptor 2B;5 HT(2B);5 HT2B;5 HT 2B;5 hydroxytryptamine (serotonin) receptor 2B;5 hydroxytryptamine 2B receptor;5 hydroxytryptamine receptor 2B;5-HT-2B;5-HT2B;5HT(2B);5HT2B_HUMAN;5HT2F;Htr 2b;NP75 protein;SEROTONIN 5HT2B RECEPTOR;Serotonin receptor 2B;Stomach fundus serotonin receptor;5-HT 2B receptor;OTTHUMP00000164294;5-hydroxytryptamine 2B receptor;5-hydroxytryptamine receptor 2B variant b;5-HT(2B)

Recombinant Proteins

  • Human
  • Rat
  • Zebrafish
  • Chicken
  • Mouse
  • Tetraodon fluviatilis (Green pufferfish) (Chelonodon fluviatilis)
  • Guinea pig
  • Wheat Germ
  • Mammalian Cell
  • HEK293
  • In vitro E. coli expression system
  • In Vitro Cell Free System
  • E.coli expression system
  • Non
  • His
  • His&Flag
  • His&Fc&Avi
  • His&SUMO
  • GST
Cat.# Product name Source (Host) Species Tag Protein Length Price
HTR2B-26027TH Recombinant Human HTR2B Wheat Germ Human Non 56 amino acids
HTR2B-2963R Recombinant Rat HTR2B Protein Mammalian Cell Rat His
HTR2B-3901Z Recombinant Zebrafish HTR2B Mammalian Cell Zebrafish His
HTR2B-5494C Recombinant Chicken HTR2B Mammalian Cell Chicken His
HTR2B-7933M Recombinant Mouse HTR2B Protein Mammalian Cell Mouse His
HTR2B-5335HCL Recombinant Human HTR2B 293 Cell Lysate HEK293 Human Non
HTR2B-1091HFL Recombinant Human HTR2B protein, His&Flag-tagged HEK293 Human His&Flag 1-481 aa
HTR2B-2618R Recombinant Rat HTR2B Protein, His (Fc)-Avi-tagged HEK293 Rat His&Fc&Avi
HTR2B-2618R-B Recombinant Rat HTR2B Protein Pre-coupled Magnetic Beads HEK293 Rat
HTR2B-2707H Recombinant Human HTR2B Full Length Transmembrane protein (1-481 aa), His-SUMO-tagged In vitro E. coli expression system Human His&SUMO Full L. 1-481aa
HTR2B-4375M Recombinant Mouse HTR2B Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
HTR2B-4375M-B Recombinant Mouse HTR2B Protein Pre-coupled Magnetic Beads HEK293 Mouse
HTR2B-5243H Recombinant Human HTR2B Protein, GST-tagged Wheat Germ Human GST
HTR2B-5684HF Recombinant Full Length Human HTR2B Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 481 amino acids
RFL1319TF Recombinant Full Length Tetraodon Fluviatilis 5-Hydroxytryptamine Receptor 2B(Htr2B) Protein, His-Tagged E.coli expression system Tetraodon fluviatilis (Green pufferfish) (Chelonodon fluviatilis) His Full L. Full Length (1-471)
RFL33072RF Recombinant Full Length Rat 5-Hydroxytryptamine Receptor 2B(Htr2B) Protein, His-Tagged E.coli expression system Rat His Full L. Full Length (1-479)
RFL34021CF Recombinant Full Length Guinea Pig 5-Hydroxytryptamine Receptor 2B(Htr2B) Protein, His-Tagged E.coli expression system Guinea pig His Full L. Full Length (1-96)
RFL5388HF Recombinant Full Length Human 5-Hydroxytryptamine Receptor 2B(Htr2B) Protein, His-Tagged E.coli expression system Human His Full L. Full Length (1-481aa)

    Involved Pathway

    HTR2B involved in several pathways and played different roles in them. We selected most pathways HTR2B participated on our site, such as Calcium signaling pathway,Neuroactive ligand-receptor interaction,Gap junction, which may be useful for your reference. Also, other proteins which involved in the same pathway with HTR2B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Inflammatory mediator regulation of TRP channels ASIC5,CYP4A12A,PIK3R1,CALM3,PLA2G4C,NGF,ASIC1,ASIC3,PRKCE,ASIC4
    Gap junction RAF1B,PRKCG,SRC,PLCB4,TUBA3C,PRKACA,MAP2K5,NRAS,DRD1A,MAP2K2
    Serotonergic synapse PRKACA,PLCB3,SLC18A1,ALOX12E,GABRB2,PLCB2,GNB3,CYP2C39,GNG13,GNG8
    Calcium signaling pathway GRM1,P2RX4B,TNNC1B,CACNA1B,EDNRBA,ATP2B2,SLC8A2B,CAMK2A,PLCD4,ADORA2A
    Neuroactive ligand-receptor interaction TAAR14F,KISS1RA,F2RL1.2,HTR6,OPRD1A,CHRNB1,DRD2A,THRB,GRIN3A,UTS2R

    Protein Function

    HTR2B has several biochemical functions, for example, G-protein alpha-subunit binding,GTPase activator activity,drug binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HTR2B itself. We selected most functions HTR2B had, and list some proteins which have the same functions with HTR2B. You can find most of the proteins on our site.

    Function Related Protein
    serotonin receptor activity HTR5A,HTR2C,HTR3B,HTR6,HTR4,HTR3A,HTR2CL1,HTR2A,HTR1E,HTR5AL
    drug binding ABP1,P2RX2,ACE,PYGB,TLR7,P2RX1,PPP3CB,SIGMAR1,UGT1A7,TYMS
    GTPase activator activity RASA1,ASAP2,GRTP1A,ARHGAP28,RGS19,GIT2,FAM13B,ARAP3,STARD13,AGAP2
    G-protein alpha-subunit binding ADRB2,RGS19,DRD1A,LPAR3,AGTR1A,ARHGEF11,IGF1R,HTR2A,PPP5C,RIC8A
    serotonin binding HTR3A,HTR2A,HTR1F,HTR2C,HTR1B,HTR1E,MAOA

    Interacting Protein

    HTR2B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HTR2B here. Most of them are supplied by our site. Hope this information will be useful for your research of HTR2B.

    MPDZ

    Resources

    Gene Families

    What is GPCR

    Research Area

    Neurotransmitter Receptors on Endothelial Cells
    Neurotransmitter G Protein-Coupled Receptors
    5-HT Receptors

    References

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