GRM8
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Official Full Name
glutamate receptor, metabotropic 8 -
Overview
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. -
Synonyms
GRM8;glutamate receptor, metabotropic 8;metabotropic glutamate receptor 8;GLUR8;GPRC1H;mGlu8;MGLUR8;FLJ41058;Glutamate receptor metabotropic 8;GRM8_HUMAN;MGC126724;MGR8;OTTHUMP00000024506;OTTHUMP00000069010;OTTHUMP00000199504;OTTHUMP00000212423
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- His
- Non
- His&Fc&Avi
- GST
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| GRM8-13546H | Recombinant Human GRM8, His-tagged | E.coli | Human | His | 31-400a.a. | |
| GRM8-1978R | Recombinant Rhesus monkey GRM8 Protein, His-tagged | Mammalian Cells | Rhesus macaque | His |
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| GRM8-2719R | Recombinant Rat GRM8 Protein | Mammalian Cells | Rat | His |
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| GRM8-28274TH | Recombinant Human GRM8 | Wheat Germ | Human | Non | 90 amino acids |
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| GRM8-5731HCL | Recombinant Human GRM8 293 Cell Lysate | HEK293 | Human | Non |
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| GRM8-1799R | Recombinant Rhesus Macaque GRM8 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| GRM8-1799R-B | Recombinant Rhesus Macaque GRM8 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| GRM8-2373R | Recombinant Rat GRM8 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| GRM8-2373R-B | Recombinant Rat GRM8 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| GRM8-5374H | Recombinant Human GRM8 Protein, GST-tagged | Wheat Germ | Human | GST |
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Involved Pathway
GRM8 involved in several pathways and played different roles in them. We selected most pathways GRM8 participated on our site, such as Phospholipase D signaling pathway,Neuroactive ligand-receptor interaction,Glutamatergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with GRM8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Phospholipase D signaling pathway | SHC4,PIK3CB,PDGFA,ARF6,KRAS,RRAS2,SYK,AGPAT4,SPHK1,GAB1 |
| Neuroactive ligand-receptor interaction | MC4R,LPAR6A,MTNR1AA,CHRND,CHRNB2,GABRP,P2RY11,S1PR4,GABRR2,TSHR |
| Glutamatergic synapse | PRKCG,PPP3CC,ADRBK2,GNGT2,GRIN3B,GNG8,GRIA3,PRKCA,GLUL,SLC17A8 |
Protein Function
GRM8 has several biochemical functions, for example, G-protein coupled receptor activity,glutamate receptor activity,group III metabotropic glutamate receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GRM8 itself. We selected most functions GRM8 had, and list some proteins which have the same functions with GRM8. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| glutamate receptor activity | GRM7,GRM2,GRIA1,GRM5,GRM1,GRIK5,GRM3,GRIK3,GRM6,GRM4 |
| group III metabotropic glutamate receptor activity | GRM7,GRM4,GRM6B,GRM6,GRM6A |
| G-protein coupled receptor activity | CXCR3.2,TAAR14L,OPN1LW2,OR2H1,V2RX1,GPR97,TAAR14D,LPAR5,OPN4.1,PTGER4B |
Interacting Protein
GRM8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GRM8 here. Most of them are supplied by our site. Hope this information will be useful for your research of GRM8.
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References
- Yang, XR; Zhang, Y; et al. Involvement of group III metabotropic glutamate receptors in the modulation of spinal nociceptive signals. NEURAL REGENERATION RESEARCH 4:443-448(2009).
- Raab, M; Boeckers, TM; et al. PROLINE-RICH SYNAPSE-ASSOCIATED PROTEIN-1 AND 2 (ProSAP1/Shank2 AND ProSAP2/Shank3)-SCAFFOLDING PROTEINS ARE ALSO PRESENT IN POSTSYNAPTIC SPECIALIZATIONS OF THE PERIPHERAL NERVOUS SYSTEM. NEUROSCIENCE 171:421-433(2010).
