F2R
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Official Full Name
Coagulation factor II (thrombin) receptor -
Overview
There are three known thrombin receptors termed PAR1, PAR3 and PAR4 (PAR for protease-activated receptor). These receptors are members of the 7 transmembrane g protein-coupled family of receptors, however, their method of activation is unique. Thrombin, a serine protease, binds to and cleaves the extracellular N-terminal domain of the receptor. A tethered ligand corresponding to the new N-terminus, SFLLRN, is then unmasked, binding to the second extracellular loop of the receptor and activating it. -
Synonyms
Coagulation factor II receptor;CF2R;Coagulation factor II (thrombin) receptor;F2R;HTR;PAR 1;PAR-1;PAR1;Protease activated receptor 1;Proteinase activated receptor 1;Proteinase-activated receptor 1;Thrombin receptor;TR
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Rat
- Mus musculus
- Bovine
- Papio hamadryas (Hamadryas baboon)
- Xenopus laevis
- E.coli
- HEK293
- Wheat Germ
- Mammalian Cell
- Human Blood
- E.coli expression system
- His
- GFP
- Non
- GST
- His&Fc&Avi
- Flag
- C-Flag&Strep
Involved Pathway
F2R involved in several pathways and played different roles in them. We selected most pathways F2R participated on our site, such as Rap signaling pathway,Calcium signaling pathway,cAMP signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with F2R were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Regulation of Actin Cytoskeleton | PAK1,PAK7,MYL2,SSH3,GNA13A,ARPC5B,ACTN1,PIK3CA,ITGA2B,DIAPH3 |
| Phospholipase D signaling pathway | KITLG,LPAR4,GAB2,FCER1A,CYTH1,PPAP2C,RALB,DNM3,PLCB3,AGPAT3 |
| Complement and coagulation cascades | C9,F9,C4A,FGB,C1QA,CR2,F2,CFD,KNG1,Serpina1b |
| cAMP signaling pathway | PPP1CC,Adcy4,RAC1,RYR2,GRIN2B,RAP1A,ARAP3,GLP1R,ATP2B4,GRIA2 |
| Endocytosis | STAMBPA,GRK1B,ZFYVE16,RAB31,DDL-2,PARD6GA,HSC70,EHD1B,PIP5K1B,ADRB3 |
| Pathways in cancer | FGFR1,PDGFRA,DAPK1,NCOA4,WNT8B,RASSF5,SKP2,WNT9A,FGFR2,PPARG |
| PIK-Akt signaling pathway | PIK3R2,FGF7,RAF1,G6PC,ANGPT4,FGFR1,CCND3,ITGA2B,IFNAR1,IFNA5 |
| Rap signaling pathway | MAP2K6,PARD6B,LPAR4,NRAS,LPAR3,GRIN2B,KRIT1,ACTB,BCAR1,RAC3 |
| Platelet activation | APBB1IP,GNAS,SRC,SNAP23,NOS3,VWF,FGA,MYLK3,PIK3R5,ITGA2 |
Protein Function
F2R has several biochemical functions, for example, G-protein alpha-subunit binding,G-protein beta-subunit binding,G-protein coupled receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by F2R itself. We selected most functions F2R had, and list some proteins which have the same functions with F2R. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| receptor binding | TIGIT,FYNA,SMAGP,MTSS1,PVRL2,PVR,RIPK2,BLK,PLXNC1,RSPO2 |
| thrombin receptor activity | F2RL2,F2RL1.1,F2RL1.2,F2RL1,GP1BA |
| G-protein coupled receptor activity | OLFR482,RGRB,OLFR8,GPR162,GPR4,NPFFR1,GPR26,OR51B5,FZD9,HTR2CL1 |
| protein binding | CABP5,ERC1,ZC3H18,MSN,EEF1D,ACTG1,FAM192A,IGF2BP1,Car4,AHNAK |
| G-protein alpha-subunit binding | DRD1A,RIC8,RGS19,LPAR1,RIC8B,RGS14,NUCB1,OPRM1,DRD1,RIC8A |
| G-protein beta-subunit binding | CCT5,F2RL1,OPRM1,GNG13,GNG2,RASD2,RGS11,RGS9,RGS7 |
Interacting Protein
F2R has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with F2R here. Most of them are supplied by our site. Hope this information will be useful for your research of F2R.
PROCR;MMP1;CAPN1;GNA13;TMED2;purL;CHRD;ATP13A2;CAV1
Resources
Research Area
Other G Protein-Coupled ReceptorsNegative Regulators of the Jak/STAT Pathway
Receptors in the Jak/STAT Pathway
Complement Regulatory Proteins
Related Services
Related Products
References
- Sung, TS; Kim, HU; et al. Protease-activated receptors modulate excitability of murine colonic smooth muscles by differential effects on interstitial cells. JOURNAL OF PHYSIOLOGY-LONDON 593:1169-1181(2015).
- D'Asti, E; Kool, M; et al. Coagulation and angiogenic gene expression profiles are defined by molecular subgroups of medulloblastoma: evidence for growth factor-thrombin cross-talk. JOURNAL OF THROMBOSIS AND HAEMOSTASIS 12:1838-1849(2014).
