PTGIR
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Official Full Name
prostaglandin I2 (prostacyclin) receptor (IP) -
Overview
The protein encoded by this gene is a member of the G-protein coupled receptor family 1 and has been shown to be a receptor for prostacyclin. Prostacyclin, the major product of cyclooxygenase in macrovascular endothelium, elicits a potent vasodilation and inhibition of platelet aggregation through binding to this receptor. -
Synonyms
PTGIR;prostaglandin I2 (prostacyclin) receptor (IP);prostacyclin receptor;IP;PGI receptor;PGI2 receptor;prostanoid IP receptor;prostaglandin I2 receptor;PRIPR;MGC102830
Recombinant Proteins
- Mouse
- Human
- Rat
- Mus musculus
- Bovine
- Mammalian Cells
- Wheat Germ
- HEK293
- E.coli
- His
- Non
- His&Fc&Avi
Involved Pathway
PTGIR involved in several pathways and played different roles in them. We selected most pathways PTGIR participated on our site, such as Neuroactive ligand-receptor interaction,Vascular smooth muscle contraction,Platelet activation, which may be useful for your reference. Also, other proteins which involved in the same pathway with PTGIR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Platelet activation | TBXAS1,MAPK13,STIM1,PRKACB,SRC,MYL12A,ACTG1,PLCB4,ORAI1,PPP1R12A |
| Neuroactive ligand-receptor interaction | MCHR1,GRM7,GRIK5,CHRNB3A,F2RL3,OXTR,GABRR3,TAAR13B,HTR1E,F2RL1.2 |
| Vascular smooth muscle contraction | RHOAA,PPP1CC,CACNA1D,PLA2G4F,GNA15.1,KCNMB1,PLA2G3,AGTR1A,CALCRLA,PLA2G12B |
Protein Function
PTGIR has several biochemical functions, for example, G-protein coupled receptor activity,guanyl-nucleotide exchange factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PTGIR itself. We selected most functions PTGIR had, and list some proteins which have the same functions with PTGIR. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| guanyl-nucleotide exchange factor activity | ARHGEF37,KNDC1,FAM116B,RASGRP3,SH2D3C,GDPGP1,ARFGEF1,ITSN2A,ARHGEF18,TRIOA |
| G-protein coupled receptor activity | F2RL1.1,OLFR491,OLFR493,MRGPRB2,OR4C12,GHRHR2,TAAR11,NPFFR2,OLFR50,FZD10 |
Interacting Protein
PTGIR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTGIR here. Most of them are supplied by our site. Hope this information will be useful for your research of PTGIR.
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