Hrh2
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Official Full Name
histamine receptor H2 -
Overview
Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. Histamine receptor H2 belongs to the family 1 of G protein-coupled receptors. It is an integral membrane protein and stimulates gastric acid secretion. It also regulates gastrointestinal motility and intestinal secretion and is thought to be involved in regulating cell growth and differentiation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. -
Synonyms
HRH2;histamine receptor H2;histamine H2 receptor;HH2R;gastric receptor 1;gastric receptor I;H2R
Recombinant Proteins
- Guinea Pig
- Human
- Rhesus macaque
- Rat
- Zebrafish
- Canine
- Western lowland gorilla
- Dog
- Pan troglodytes
- Mus musculus
- Guinea pig
- Pongo Pygmaeus
- Gorilla gorilla gorilla (Western lowland gorilla)
- Sf9 Insect Cell
- Mammalian Cell
- Wheat Germ
- Insect Cell
- HEK293
- In Vitro Cell Free System
- E.coli
- E.coli expression system
- Non
- His
- His&Flag
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Hrh2-1043G | Recombinant Guinea Pig Histamine Receptor H 2 | Sf9 Insect Cell | Guinea Pig | Non |
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| HRH2-1047H | Recombinant Human Histamine Receptor H 2 | Sf9 Insect Cell | Human | Non |
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| Hrh2-1143R | Hrh2; Histamine receptor H 2; H2R; Histamine H2 receptor | Sf9 Insect Cell | Non |
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| HRH2-2143R | Recombinant Rhesus monkey HRH2 Protein, His-tagged | Mammalian Cell | Rhesus macaque | His |
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| HRH2-27612TH | Recombinant Human HRH2 | Human | His&Flag | Full L. |
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| HRH2-2912R | Recombinant Rat HRH2 Protein | Mammalian Cell | Rat | His |
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| HRH2-4320Z | Recombinant Zebrafish HRH2 | Mammalian Cell | Zebrafish | His |
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| HRH2-5036H | Recombinant Human HRH2 Protein | Wheat Germ | Human | Non |
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| HRH2-783C | Recombinant Canine HRH2 Protein, His/FLAG-tagged | Insect Cell | Canine | His&Flag |
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| Hrh2-788R | Recombinant Rat Hrh2 Protein | Insect Cell | Rat | Non |
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| HRH2-1964R | Recombinant Rhesus Macaque HRH2 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| HRH2-1964R-B | Recombinant Rhesus Macaque HRH2 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| HRH2-2567R | Recombinant Rat HRH2 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| HRH2-2567R-B | Recombinant Rat HRH2 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| HRH2-3666HF | Recombinant Full Length Human HRH2 Protein | In Vitro Cell Free System | Human | Full L. 218 amino acids |
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| HRH2-5632W | Recombinant Western lowland gorilla HRH2 protein, His-tagged | E.coli | Western lowland gorilla | His | 290-359a.a. |
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| RFL13399CF | Recombinant Full Length Dog Histamine H2 Receptor(Hrh2) Protein, His-Tagged | E.coli expression system | Dog | His | Full L. Full Length (1-359) |
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| RFL14624PF | Recombinant Full Length Pan Troglodytes Histamine H2 Receptor(Hrh2) Protein, His-Tagged | E.coli expression system | Pan troglodytes | His | Full L. Full Length (1-359) |
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| RFL18362MF | Recombinant Full Length Mouse Histamine H2 Receptor(Hrh2) Protein, His-Tagged | E.coli expression system | Mus musculus | His | Full L. Full Length (1-358) |
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| RFL19947RF | Recombinant Full Length Rat Histamine H2 Receptor(Hrh2) Protein, His-Tagged | E.coli expression system | Rat | His | Full L. Full Length (1-358) |
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| RFL23220CF | Recombinant Full Length Guinea Pig Histamine H2 Receptor(Hrh2) Protein, His-Tagged | E.coli expression system | Guinea pig | His | Full L. Full Length (1-359) |
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| RFL31377PF | Recombinant Full Length Pongo Pygmaeus Histamine H2 Receptor(Hrh2) Protein, His-Tagged | E.coli expression system | Pongo Pygmaeus | His | Full L. Full Length (1-359) |
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| RFL32241HF | Recombinant Full Length Human Histamine H2 Receptor(Hrh2) Protein, His-Tagged | E.coli expression system | Human | His | Full L. Full Length (1-359) |
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| RFL35297GF | Recombinant Full Length Gorilla Gorilla Gorilla Histamine H2 Receptor(Hrh2) Protein, His-Tagged | E.coli expression system | Gorilla gorilla gorilla (Western lowland gorilla) | His | Full L. Full Length (1-359) |
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Involved Pathway
Hrh2 involved in several pathways and played different roles in them. We selected most pathways Hrh2 participated on our site, such as Calcium signaling pathway,Neuroactive ligand-receptor interaction,Gastric acid secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with Hrh2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Gastric acid secretion | CAMK2B,ATP4B,GNAI2,KCNJ1,ATP1A4,ITPR1,CCKBR,PRKACB,Car2,KCNE2 |
| Neuroactive ligand-receptor interaction | TAAR14D,EDNRB2,DRD4A,HTR1AA,GHRA,TAAR64,TAAR7B,S1PR3,GHR,TAAR1 |
| Calcium signaling pathway | PLCD3,AGTR1B,CAMK2A,ADRa1A,CACNA1B,AKR1C1,ATP2A1,DRD1A,PPP3R1,PLCZ1 |
Protein Function
Hrh2 has several biochemical functions, for example, NOT dopamine binding,NOT dopamine neurotransmitter receptor activity, coupled via Gs,histamine receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Hrh2 itself. We selected most functions Hrh2 had, and list some proteins which have the same functions with Hrh2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| histamine receptor activity | HRH4,HRH1,HTR6,HRH3 |
Interacting Protein
Hrh2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Hrh2 here. Most of them are supplied by our site. Hope this information will be useful for your research of Hrh2.
cimetidine;aminopotentidine
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References
- Toubanaki, DK; Christopoulos, TK; et al. High-throughput chemiluminometric genotyping of single nucleotide polymorphisms of histamine, serotonin, and adrenergic receptor genes. ANALYTICAL BIOCHEMISTRY 385:34-41(2009).
