EDNRA

  • Official Full Name

    endothelin receptor type A

  • Overview

    This gene encodes the receptor for endothelin-1, a peptide that plays a role in potent and long-lasting vasoconstriction. This receptor associates with guanine-nucleotide-binding (G) proteins, and this coupling activates a phosphatidylinositol-calcium second messenger system. Polymorphisms in this gene have been linked to migraine headache resistance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

  • Synonyms

    EDNRA;endothelin receptor type A;ETA;ET-A;ETAR;ETRA;ETA-R;hET-AR;endothelin-1 receptor;G protein-coupled receptor;endothelin receptor subtype A;endothelin-1-specific receptor

Recombinant Proteins

  • Human
  • Rhesus macaque
  • Mouse
  • Chicken
  • Rat
  • Bovine
  • Mus musculus
  • Sus scrofa (Pig)
  • Dog
  • Sheep
  • E. coli
  • Wheat Germ
  • HEK293
  • Mammalian Cell
  • E.coli
  • In vitro E. coli expression system
  • In Vitro Cell Free System
  • Yeast
  • E.coli expression system
  • N-GST
  • Non
  • His
  • GST
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
ACYP1-9362H Recombinant Human ACYP1 protein, GST-tagged E. coli Human N-GST 1-99 aa
EDNRA-22H Recombinant Human EDNRA Protein Wheat Germ Human Non
EDNRA-764H Active Recombinant Human EDNRA Full Length Transmembrane protein(VLPs) HEK293 Human Non Full L. Asp 21 - Asn 427
EDNRA-1380R Recombinant Rhesus monkey EDNRA Protein, His-tagged Mammalian Cell Rhesus macaque His
EDNRA-28562TH Recombinant Human EDNRA Wheat Germ Human Non 63 amino acids
EDNRA-3058H Recombinant Human EDNRA Protein, GST-tagged Wheat Germ Human GST
EDNRA-4994M Recombinant Mouse EDNRA Protein Mammalian Cell Mouse His
EDNRA-5695C Recombinant Chicken EDNRA Mammalian Cell Chicken His
EDNRA-6718HCL Recombinant Human EDNRA 293 Cell Lysate HEK293 Human Non
EDNRA-1205R Recombinant Rhesus Macaque EDNRA Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque His&Fc&Avi
EDNRA-1205R-B Recombinant Rhesus Macaque EDNRA Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
EDNRA-1405H Recombinant Human EDNRA Protein, His-tagged E.coli Human His Asp21-Lys80
EDNRA-2371H Recombinant Human EDNRA Full Length Transmembrane protein, His-tagged In vitro E. coli expression system Human His Full L. 21–427aa
EDNRA-2641M Recombinant Mouse EDNRA Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
EDNRA-2641M-B Recombinant Mouse EDNRA Protein Pre-coupled Magnetic Beads HEK293 Mouse
EDNRA-4202HF Recombinant Full Length Human EDNRA Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 427 amino acids
EDNRA-5392H Recombinant Human EDNRA protein, His-tagged Yeast Human His 21-80aa
EDNRA-6775HF Recombinant Full Length Human EDNRA Protein In Vitro Cell Free System Human Full L. was amino acids
RFL24996RF Recombinant Full Length Rat Endothelin-1 Receptor(Ednra) Protein, His-Tagged E.coli expression system Rat His Full L. Full Length (21-426)
RFL2534BF Recombinant Full Length Bovine Endothelin-1 Receptor(Ednra) Protein, His-Tagged E.coli expression system Bovine His Full L. Full Length (21-427)
RFL27599MF Recombinant Full Length Mouse Endothelin-1 Receptor(Ednra) Protein, His-Tagged E.coli expression system Mus musculus His Full L. Full Length (21-427)
RFL6245SF Recombinant Full Length Pig Endothelin-1 Receptor(Ednra) Protein, His-Tagged E.coli expression system Sus scrofa (Pig) His Full L. Full Length (21-427)
RFL7029CF Recombinant Full Length Dog Endothelin-1 Receptor(Ednra) Protein, His-Tagged E.coli expression system Dog His Full L. Full Length (21-426)
RFL7142OF Recombinant Full Length Sheep Endothelin-1 Receptor(Ednra) Protein, His-Tagged E.coli expression system Sheep His Full L. Full Length (21-427)

    Involved Pathway

    EDNRA involved in several pathways and played different roles in them. We selected most pathways EDNRA participated on our site, such as Calcium signaling pathway,Class A/1 (Rhodopsin-like receptors),EGFR-dependent Endothelin signaling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with EDNRA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Calcium signaling pathway TACR3A,CHRM5,ADORA2AB,AGTR1,GNA15,AKR1C1,TNNC1B,ATP2A2B,CALM4,HTR7
    G alpha (q) signalling events KALRNB,CYSLTR1,RGS19,KISS1,TRH,NPFFR2,NMUR1,FPR-RS4,TAE1,PROK1
    Endothelins EDNRB,CYSLTR1,COL1A2,EDN3,EDN1,COL3A1,EDN2
    Class A/1 (Rhodopsin-like receptors) OXER1,GPR55A,GPR120,HCAR1-2,GPR55,GPR37L1,OXGR1A.1,PNOC,GPBAR1,GPR4
    GPCR downstream signaling PROKR2,CALCA,RHOC,RGS11,RXFP2,TAC1,ADORA3,ADORA1,OR4D2,AGT
    GPCR ligand binding AMCF-II,OXGR1,ADORA1,SCT,PENK,CX3CR1,OPN4,GPR4,CHRM5,EMR2
    Endothelin EDNRB,ECE1,MYL1,CNN1,EDN1,CALCRL,RAMP1,CALCA
    EGFR-dependent Endothelin signaling events EDN1

    Protein Function

    EDNRA has several biochemical functions, for example, endothelin receptor activity,phosphatidylinositol phospholipase C activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EDNRA itself. We selected most functions EDNRA had, and list some proteins which have the same functions with EDNRA. You can find most of the proteins on our site.

    Function Related Protein
    protein binding BEND7,KATNA1,CLDN2,PDE2A,ALOX12,ITPKB,RGP1,PHF7,FABP5,UNKL
    phosphatidylinositol phospholipase C activity BDKRB2,PLCG1,CHRM5,PLCL2,CCR1,PLCB1,PLCB4,PLCD3A,CASR,PLCD1
    endothelin receptor activity EDNRAA,EDNRBA,EDNRB,EDNRAB

    Interacting Protein

    EDNRA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EDNRA here. Most of them are supplied by our site. Hope this information will be useful for your research of EDNRA.

    EDN1

    Resources

    Gene Families

    What is GPCR

    Research Area

    Peptide Receptors on VSMC

    References

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