ADRBK1
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Official Full Name
adrenergic, beta, receptor kinase 1 -
Overview
G-protein-coupled receptor kinase 2 (GRK2), also known as beta-adrenergic receptor kinase 1 (beta-ARK1), is a member of the GRK family, which phosphorylates the activated form of G-protein-coupled receptors (GPCRs) and initiates the desensitization proces -
Synonyms
ADRBK1;adrenergic, beta, receptor kinase 1;beta-adrenergic receptor kinase 1;BARK1;GRK2;beta-ARK-1;G-protein coupled receptor kinase 2;BETA-ARK1;FLJ16718
Recombinant Proteins
- Human
- Chicken
- Rat
- Insect Cell
- Sf9 Insect Cell
- Mammalian Cell
- Insect Cells
- Insect (sf21)
- HEK293
- GST
- His
- His&GST
- Non
- His&Fc&Avi
Involved Pathway
ADRBK1 involved in several pathways and played different roles in them. We selected most pathways ADRBK1 participated on our site, such as Activation of SMO,CXCR4-mediated signaling events,Ca-dependent events, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADRBK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| DAP12 interactions | RASGEF1A,SIRPB1,PHB,SIGLEC14,DUSP9,FGF8B,CNKSR1,THEM4,PRKAR1AA,TRAT1 |
| Activation of SMO | EFCAB7,SETD6,EVC2,BOC,CDON,IQCE,EVC,GAS8,KIF3A,CSNK1A1 |
| CaM pathway | PRKAR1AA |
| Chemokine signaling pathway | CCR6,GNG12,GNAI3,CCL26,CCL17,GNB3,CCL8,Cxcl15,GRK5,CRK |
| Calmodulin induced events | PRKAR1AA |
| DAG and IP3 signaling | AHCYL1,PRKAR1AA |
| Ca-dependent events | PRKAR1AA,ADCY7,ADCY9 |
| CXCR4-mediated signaling events | GNA13,CSK,GNB2L1,CRK,CFL1,BLK,JAK2,PAG1,DNM1,MAPKAP1 |
Protein Function
ADRBK1 has several biochemical functions, for example, ATP binding,Edg-2 lysophosphatidic acid receptor binding,G-protein coupled receptor kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ADRBK1 itself. We selected most functions ADRBK1 had, and list some proteins which have the same functions with ADRBK1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| G-protein coupled receptor kinase activity | GRK7B,RLN1,GRK1B,GRK1A,GRK4,GRK1,GRK7A,GRK5,ADRBK2,GRK6 |
| ATP binding | KIF26A,DDX50,BCS1L,PHKG1B,UBE2A,STK35,TRIO,ADCK2,PFAS,MYO15 |
| beta-adrenergic receptor kinase activity | GRK5,GRK6,ADRBK2 |
| protein kinase activity | PRKCHB,PTK2AB,JAK2A,DCKL1B,OXSR1A,DYRK1A,MAP2K5,CAMK1DA,SNRKB,MAP3K5 |
| alpha-2A adrenergic receptor binding | ADRB1,UCHL1,APLP1,ADRA2C |
| protein binding | GM885,VRK1,PKD1L3,LAIR2,NDUFB9,NMU,PML,MMP15,EXOSC1,RSPH3 |
Interacting Protein
ADRBK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADRBK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADRBK1.
UBC;FPR1;EGFR;HDAC6;GIT1;TUBB;MDM2
Resources
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References
- Wex, E; Thaler, E; et al. A Novel Model of IgE-Mediated Passive Pulmonary Anaphylaxis in Rats. PLOS ONE 9:-(2014).
- Hartung, JE; Ciszek, BP; et al. beta(2)- and beta(3)-adrenergic receptors drive COMT-dependent pain by increasing production of nitric oxide and cytokines. PAIN 155:1346-1355(2014).
