MTNR1A
-
Official Full Name
melatonin receptor 1A -
Overview
This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This receptor is a G-protein coupled, 7-transmembrane receptor that is responsible for melatonin effects on mammalian circadian rhythm and reproductive alterations affected by day length. The receptor is an integral membrane protein that is readily detectable and localized to two specific regions of the brain. The hypothalamic suprachiasmatic nucleus appears to be involved in circadian rhythm while the hypophysial pars tuberalis may be responsible for the reproductive effects of melatonin. -
Synonyms
MTNR1A;melatonin receptor 1A;melatonin receptor type 1A;MEL 1A R;MEL-1A-R;Mel1a melatonin receptor;Mel1a receptor;MelR;MR;MT 1;MT1;MTNR 1A;MTR1A_HUMAN
Recombinant Proteins
- Human
- Chicken
- Cattle
- Goat
- Mouse
- Mus musculus
- Phodopus sungorus (Striped hairy-footed hamster) (Djungarian hamster)
- Rat
- Sheep
- Sus scrofa (Pig)
- Bovine
- Wheat Germ
- Mammalian Cell
- E.coli
- HEK293
- Mammalian cells
- HEK293T
- E.coli expression system
- Non
- His
- His&S
- His&Fc&Avi
- Flag
- GST
- Myc&DDK
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| MTNR1A-30196TH | Recombinant Human MTNR1A | Wheat Germ | Human | Non | 55 amino acids |
|
| MTNR1A-6914C | Recombinant Chicken MTNR1A | Mammalian Cell | Chicken | His |
|
|
| MTNR1A-8162C | Recombinant Cattle MTNR1A protein, His & S-tagged | E.coli | Cattle | His&S | Gly216~Pro257 |
|
| MTNR1A-8163G | Recombinant Goat MTNR1A protein, His & S-tagged | E.coli | Goat | His&S | Gly312~Val366 |
|
| MTNR1A-8164H | Recombinant Human MTNR1A protein, His-tagged | E.coli | Human | His | Gly296~Val350 |
|
| Mtnr1a-8165M | Recombinant Mouse Mtnr1a protein, His-tagged | E.coli | Mouse | His | Leu300~Val353 |
|
| MTNR1A-4071HCL | Recombinant Human MTNR1A 293 Cell Lysate | HEK293 | Human | Non |
|
|
| MTNR1A-1142C | Recombinant Chicken MTNR1A Protein, His-tagged | E.coli | Chicken | His | Gly299-Val353 |
|
| MTNR1A-1455H | Recombinant Human MTNR1A Protein, His (Fc)-Avi-tagged | HEK293 | Human | His&Fc&Avi |
|
|
| MTNR1A-1455H-B | Recombinant Human MTNR1A Protein Pre-coupled Magnetic Beads | HEK293 | Human |
|
||
| MTNR1A-1482HFL | Recombinant Full Length Human MTNR1A Protein, C-Flag-tagged | Mammalian cells | Human | Flag | Full L. |
|
| MTNR1A-301234H | Recombinant Human MTNR1A protein, GST-tagged | E.coli | Human | GST | Met1-Ile42 |
|
| Mtnr1a-4221M | Recombinant Mouse Mtnr1a Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
|
|
| MTNR1A-556H | Recombinant Human MTNR1A Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
|
|
| MTNR1A-5726H | Recombinant Human MTNR1A Protein, GST-tagged | Wheat Germ | Human | GST |
|
|
| RFL1203MF | Recombinant Full Length Mouse Melatonin Receptor Type 1A(Mtnr1A) Protein, His-Tagged | E.coli expression system | Mus musculus | His | Full L. Full Length (1-353) |
|
| RFL21682PF | Recombinant Full Length Phodopus Sungorus Melatonin Receptor Type 1A(Mtnr1A) Protein, His-Tagged | E.coli expression system | Phodopus sungorus (Striped hairy-footed hamster) (Djungarian hamster) | His | Full L. Full Length (1-353) |
|
| RFL23708RF | Recombinant Full Length Rat Melatonin Receptor Type 1A(Mtnr1A) Protein, His-Tagged | E.coli expression system | Rat | His | Full L. Full Length (1-156) |
|
| RFL25648OF | Recombinant Full Length Sheep Melatonin Receptor Type 1A(Mtnr1A) Protein, His-Tagged | E.coli expression system | Sheep | His | Full L. Full Length (1-366) |
|
| RFL3278SF | Recombinant Full Length Pig Melatonin Receptor Type 1A(Mtnr1A) Protein, His-Tagged | E.coli expression system | Sus scrofa (Pig) | His | Full L. Full Length (1-154) |
|
| RFL34539BF | Recombinant Full Length Bovine Melatonin Receptor Type 1A(Mtnr1A) Protein, His-Tagged | E.coli expression system | Bovine | His | Full L. Full Length (1-257) |
|
| RFL8448HF | Recombinant Full Length Human Melatonin Receptor Type 1A(Mtnr1A) Protein, His-Tagged | E.coli expression system | Human | His | Full L. Full Length (1-350) |
|
Involved Pathway
MTNR1A involved in several pathways and played different roles in them. We selected most pathways MTNR1A participated on our site, such as Neuroactive ligand-receptor interaction,Circadian entrainment, which may be useful for your reference. Also, other proteins which involved in the same pathway with MTNR1A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Neuroactive ligand-receptor interaction | CHRM2A,HTR2B,NMUR1,GNRHR,P2RX4A,TAAR15,GRIN2A,AGTR2,LEPB,TAAR10D |
| Circadian entrainment | GNB1,GNG4,CALM2,PRKACB,MTNR1B,PRKG1,CAMK2A,PER3,GNG7,RYR3 |
Protein Function
MTNR1A has several biochemical functions, for example, hormone binding,melatonin receptor activity,organic cyclic compound binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MTNR1A itself. We selected most functions MTNR1A had, and list some proteins which have the same functions with MTNR1A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| organic cyclic compound binding | SLC16A1 |
| hormone binding | GPR30,NPR3,AMHR2,TTR,NPR2,NPR1,ADIPOR1A,MC1R,CRYM,UCN2 |
| protein binding | C14orf104,ZFP335,SLAMF6,ANKRD10,BYSL,PFN1,ZKSCAN3,OPRL1,KAT7,TBX5 |
| melatonin receptor activity | MTNR1C,MTNR1BA,MTNR1AA,MTNR1B,MTNR1BB,GPR50,MTNR1AL |
Interacting Protein
MTNR1A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MTNR1A here. Most of them are supplied by our site. Hope this information will be useful for your research of MTNR1A.
RGS20;MTNR1B;PGRMC1;IRS4;VAPB;GNAI2;GNAI3;CNP;HSPA5;EEF1G;CALR;CANX;TMEM33;RAB10
Resources
Related Services
Related Products
References
- Arias-Santiago, S; Aneiros-Fernandez, J; et al. MTNR1A Receptor Expression in Normal and Pathological Human Salivary Glands. ANTICANCER RESEARCH 32:4765-4771(2012).
- Adamah-Biassi, EB; Zhang, Y; et al. Distribution of MT1 Melatonin Receptor Promoter-Driven RFP Expression in the Brains of BAC C3H/HeN Transgenic Mice. JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY 62:70-84(2014).
- Dimitrov, R; Georgiev, G; et al. MEMBRANE MELATONIN RECEPTOR TYPE MT1 EXPRESSION IN HUMAN EJACULATED SPERMATOZOA. COMPTES RENDUS DE L ACADEMIE BULGARE DES SCIENCES 65:947-952(2012).
