GHRHR
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Official Full Name
growth hormone releasing hormone receptor -
Overview
This gene encodes a receptor for growth hormone-releasing hormone. Binding of this hormone to the receptor leads to synthesis and release of growth hormone. Mutations in this gene have been associated with isolated growth hormone deficiency (IGHD), also known as Dwarfism of Sindh, a disorder characterized by short stature. -
Synonyms
GHRHR;growth hormone releasing hormone receptor;growth hormone-releasing hormone receptor;GHRFR;GHRH R;GHRH receptor;GHRHR_HUMAN;GHRHRpsv;GRF R;GRF receptor;GRFR;Growth hormone releasing factor receptor;Growth hormone-releasing factor receptor;IGHD1B
Recombinant Proteins
- Rat
- Human
- Chicken
- Mouse
- Sus scrofa (Pig)
- Mus musculus
- Mammalian Cells
- Wheat Germ
- E.coli
- HEK293
- His
- Non
- His&GST
- His&Flag
- His&Fc&Avi
- GST
Involved Pathway
GHRHR involved in several pathways and played different roles in them. We selected most pathways GHRHR participated on our site, such as Neuroactive ligand-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with GHRHR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Neuroactive ligand-receptor interaction | GRIN1A,S1PR4,NPY7R,GRIN2A,CHRNB3,HTR2B,PTGER1C,GABRQ,P2RX4,GRPR |
Protein Function
GHRHR has several biochemical functions, for example, G-protein coupled receptor activity,growth factor binding,growth hormone-releasing hormone receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GHRHR itself. We selected most functions GHRHR had, and list some proteins which have the same functions with GHRHR. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | NQO2,KIF22,USP20,ARL4C,KEL,COX5A,BMP2,GGPS1,HSPA4,ANKRD1 |
| growth hormone-releasing hormone receptor activity | GHSR,GHSRA,MLNR,GHRHRA |
| G-protein coupled receptor activity | FPR-RS3,KISS1RB,RGS1,NMUR2,EDNRAA,GPR183,CD97,FPR-RS4,GNRHR1,MRGPRB3 |
| peptide hormone binding | MC4R,ANXA5,GIPR,GALR1,PTH1RA,HCRTR1,NPR1,GALR3,OXTR,GHR |
| growth factor binding | ACVR1C,TEK,KDR,OSMR,FLT4,NKD2,RPL37,NRP1,ACVR2A,NRP2 |
Interacting Protein
GHRHR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GHRHR here. Most of them are supplied by our site. Hope this information will be useful for your research of GHRHR.
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References
- Kale, S; Budyal, S; et al. A novel gross indel in the growth hormone releasing hormone receptor gene of Indian IGHD patients. GROWTH HORMONE & IGF RESEARCH 24:227-232(2014).
- Qi, QE; Xi, QY; et al. Alteration of the miRNA expression profile in male porcine anterior pituitary cells in response to GHRH and CST and analysis of the potential roles for miRNAs in regulating GH. GROWTH HORMONE & IGF RESEARCH 25:66-74(2015).
