DARC
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Official Full Name
Duffy blood group, chemokine receptor -
Overview
The protein encoded by this gene is a glycosylated membrane protein and a non-specific receptor for several chemokines. The encoded protein is the receptor for the human malarial parasites Plasmodium vivax and Plasmodium knowlesi. Polymorphisms in this gene are the basis of the Duffy blood group system. Two transcript variants encoding different isoforms have been found for this gene. -
Synonyms
DARC;Duffy blood group, chemokine receptor;Duffy blood group , FY;Duffy antigen/chemokine receptor;CCBP1;CD234;Dfy;GPD;glycoprotein D;Fy glycoprotein;Duffy blood group antigen;plasmodium vivax receptor;FY;GpFy;WBCQ1
Recombinant Proteins
- Human
- Wheat Germ
- In Vitro Cell Free System
- E.coli
- Non
- His
- GST
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| DARC-26807TH | Recombinant Human DARC | Wheat Germ | Human | Non | 336 amino acids |
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| DARC-115HF | Recombinant Full Length Human DARC Protein | In Vitro Cell Free System | Human | Full L. 336 amino acids |
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| DARC-1312H | Recombinant Human DARC Protein, His-tagged | E.coli | Human | His | Val176-Leu332 |
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| DARC-26807H | Recombinant Human DARC Protein | Wheat Germ | Human |
|
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| DARC-4582H | Recombinant Human DARC Protein, GST-tagged | Wheat Germ | Human | GST |
|
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| DARC-5281HF | Recombinant Full Length Human DARC Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 336 amino acids |
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| DARC-6856HF | Recombinant Full Length Human DARC Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 336 amino acids |
|
Involved Pathway
DARC involved in several pathways and played different roles in them. We selected most pathways DARC participated on our site, such as Malaria, which may be useful for your reference. Also, other proteins which involved in the same pathway with DARC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Malaria | ITGB2L,SDC2,TNF,LRP1,GYPA,HBB-B2,TLR4,HGF,PECAM1,KLRB1 |
Protein Function
DARC has several biochemical functions, for example, C-C chemokine binding,G-protein coupled receptor activity,receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DARC itself. We selected most functions DARC had, and list some proteins which have the same functions with DARC. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transmembrane signaling receptor activity | CLEC4A,OR115-6,TNFRSF8,IL1R1,NRXN1,CLEC2D,GPR113,TNFRSF11A,SEMA4D,P2RX6 |
| G-protein coupled receptor activity | TAAR14E,GHRHRL,TAS2R140,V2RH14,ZNF514,LPAR4,CHRM5A,OLFR78,TAAR11,OLFR493 |
| C-C chemokine binding | CCR5,ZFP36,CCBP2,CCR1 |
| receptor activity | GRIA2A,ANTXR2B,CD1D,ITGB1B,KRT1,GRIK3,SIGLEC7,TNFRSF10A,GFRA1A,GFRA4A |
Interacting Protein
DARC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DARC here. Most of them are supplied by our site. Hope this information will be useful for your research of DARC.
Resources
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References
- Meyer, S; Vollmert, C; et al. High-throughput Kell, Kidd, and Duffy matrix-assisted laser desorption/ionization, time-of-flight mass spectrometry-based blood group genotyping of 4000 donors shows close to full concordance with serotyping and detects new alleles. TRANSFUSION 54:3198-3207(2014).
- de Sousa, TN; Kano, FS; et al. The Duffy binding protein as a key target for a Plasmodium vivax vaccine: lessons from the Brazilian Amazon. MEMORIAS DO INSTITUTO OSWALDO CRUZ 109:608-617(2014).
