CRHR1
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Official Full Name
corticotropin releasing hormone receptor 1 -
Overview
This gene encodes a G-protein coupled receptor that binds neuropeptides of the corticotropin releasing hormone family that are major regulators of the hypothalamic-pituitary-adrenal pathway. The encoded protein is essential for the activation of signal transduction pathways that regulate diverse physiological processes including stress, reproduction, immune response and obesity. Alternative splicing results in multiple transcript variants, one of which represents a read-through transcript with the neighboring gene MGC57346. [provided by RefSeq, Jan 2012] -
Synonyms
CRHR1;corticotropin releasing hormone receptor 1;CRF1;CRHR;CRF-R;CRFR1;CRF-R1;CRFR-1;CRH-R1;CRHR1L;CRHR1f;CRF-R-1;CRH-R-1;CRH-R1h;corticotropin-releasing factor receptor 1;CRH receptor 1 variant B;seven transmembrane helix receptor;corticotropin-releasing hormone receptor 1;corticotropin-releasing factor type 1 receptor;corticotropin releasing hormone receptor variant 1e;corticotropin releasing hormone receptor variant 1g
Recombinant Proteins
- Rhesus macaque
- Rat
- Human
- Chicken
- Mouse
- Xenopus laevis
- Sheep
- Mus musculus
- Macaca mulatta
- Mammalian Cell
- Wheat Germ
- HEK293
- Yeast
- In Vitro Cell Free System
- E.coli
- E.coli expression system
- His
- Non
- GST
- His&Flag
- His&Fc&Avi
Involved Pathway
CRHR1 involved in several pathways and played different roles in them. We selected most pathways CRHR1 participated on our site, such as Class B/2 (Secretin family receptors),Corticotropin-releasing hormone,G alpha (s) signalling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with CRHR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Myometrial Relaxation and Contraction Pathways | ACTA1,GUCA2A,IGFBP5,IGFBP2,RGS7,RGS11,RXFP2,CNN2,PKIB,GABPB1 |
| GPCR ligand binding | PROKR1A,ADCYAP1R1,CXCR6,OPN1MW2,PPY,OXER1,ANXA1,FPR-RS3,PYY,PROKR1 |
| Long-term depression | PLCB3,ITPR3,GNAI1,GNA11,BRAF,NRAS,MAP2K1,PPP2CB,GRM1,GNAZ |
| Corticotropin-releasing hormone | TCF4,CYP21A2,IVL,ADRBK2,KRT1,TRIM28,CYP11B1,PARP1,JUND,TBX19 |
| Class B/2 (Secretin family receptors) | RCA2.1,SCT,FZD10,CALCB,ADM2,GHRH,RAMP1,ADM,GNB3A,CALCA |
| GPCRs, Class B Secretin-like | EMR2,ELTD1,CALCRL,EMR1,ADCYAP1R1,CD97,CRHR2,LPHN1 |
| GPCR downstream signaling | HEBP1,PPY,ANXA1B,RLN3,ADORA3,TAC2,RGS10,CXCR7B,GNA13B,KISS1 |
| G alpha (s) signalling events | ADORA2B,GHRH,GCGB,PTHLHA,CRH,PTH2,RAMP3,VIP,RLN2,GPBAR1 |
Protein Function
CRHR1 has several biochemical functions, for example, G-protein alpha-subunit binding,corticotrophin-releasing factor receptor activity,corticotropin-releasing hormone binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CRHR1 itself. We selected most functions CRHR1 had, and list some proteins which have the same functions with CRHR1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| corticotrophin-releasing factor receptor activity | CRHR2 |
| corticotropin-releasing hormone binding | CRHBP |
| protein binding | CRX,GTF2A1L,PPM1G,PHF23,CD1B,GGA2,HTRA2,TKT,CCK,STOML1 |
| G-protein alpha-subunit binding | RIC8B,AGTR1A,DRD1,RIC8,HTR2A,PPP5C,IGF1R,DRD1A,F2R,RIC8A |
| protein complex binding | NFYB,VHLL,TRADD,THRA,STRN4,CEBPA,WASF2,KHDRBS1,ST13,SH2B3 |
| corticotropin-releasing hormone receptor activity | CRHR2 |
Interacting Protein
CRHR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CRHR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CRHR1.
CRH;SRPK1;CALM1
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References
- Liguori, G; Squillacioti, C; et al. Presence and Distribution of Urocortin and its Receptors in the Epididymis of Alpaca (Vicugna pacos). ANATOMIA HISTOLOGIA EMBRYOLOGIA 44:66-71(2015).
- Squillacioti, C; De Luca, A; et al. Presence and Distribution of Urocortin and Corticotrophin-Releasing Hormone Receptors in the Bovine Thyroid Gland. ANATOMIA HISTOLOGIA EMBRYOLOGIA 43:429-434(2014).
