ADRB2
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Official Full Name
adrenoceptor beta 2, surface -
Overview
This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes. [provided by RefSeq, Jul 2008] -
Synonyms
ADRB2;adrenoceptor beta 2, surface;BAR;B2AR;ADRBR;ADRB2R;BETA2AR;beta-2 adrenergic receptor;beta-2 adrenoceptor;beta-2 adrenoreceptor;catecholamine receptor;adrenoceptor beta 2 surface;adrenergic, beta-2-, receptor, surface
Recombinant Proteins
- Mouse
- Human
- Rhesus macaque
- Cynomolgus
- Bovine
- Rat
- Dog
- Guinea pig
- Oncorhynchus Mykiss
- Meriones unguiculatus (Mongolian jird) (Mongolian gerbil)
- Mus musculus
- Tscherskia triton (Greater long-tailed hamster)
- Sus scrofa (Pig)
- Felis catus
- Mesocricetus auratus
- Macaca mulatta
- Mammalian Cell
- Wheat Germ
- HEK293
- E.coli
- In vitro E. coli expression system
- In Vitro Cell Free System
- E.coli expression system
- His
- Non
- GST
- His&Flag
- His&SUMO
- His&Fc&Avi
- N-His-B2M
Involved Pathway
ADRB2 involved in several pathways and played different roles in them. We selected most pathways ADRB2 participated on our site, such as Adrenergic signaling in cardiomyocytes,Adrenoceptors,Amine ligand-binding receptors, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADRB2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Class A/1 (Rhodopsin-like receptors) | OPN4,ADRA1B,DRD2,S1PR1,GPR37L1,GPR132,CCR8,NPS,ADRA2B,OPN1LW |
| Amine ligand-binding receptors | CHRM1,ADRA2B,ADRB1,CHRM4,DRD3,ADRA1B,HRH3,DRD4,ADRA2A,TAAR1 |
| Calcium signaling pathway | ITPR1,SLC8A1B,ADRB3B,PRKCA,CALM1B,ORAI3,ERBB3B,P2RX8,PRKACBA,ADORA2A |
| Adrenergic signaling in cardiomyocytes | ADRB1,CALM3,MAPK14,PPP2R2B,CACNG4,ADRB3A,ATP2B3B,PPP1CBL,ADRA1B,SCN4BA |
| Adrenoceptors | ADRA2C,ADRA2A,ADRB3,ADRA1D,ADRA1B,ADRA2B,ADRa1A,ADRB1 |
| Arf6 signaling events | FBXO8,EPHA2,AGTR1,ARAP2,USP6,IPCEF1,EGF,EFNA1,KIF13B,GULP1 |
| Calcium Regulation in the Cardiac Cell | GJA8,RGS5B,FKBP1A,CX55.5,CX30.3,RGS7,GJB4,CHRM1,RGS17,CX34.4 |
| Arf6 trafficking events | CPE,EXOC1,DNM2,CTNNA1,CHRM2,EDNRB,PTBP3,JUP,EXOC3,CLTC |
Protein Function
ADRB2 has several biochemical functions, for example, B2 bradykinin receptor binding,G-protein alpha-subunit binding,adenylate cyclase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ADRB2 itself. We selected most functions ADRB2 had, and list some proteins which have the same functions with ADRB2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| G-protein alpha-subunit binding | ARHGEF11,CRHR1,HTR2B,PPP5C,LPAR1,RIC8,AGTR1A,IGF1R,DRD1,RGS19 |
| dopamine binding | DRD1,DRD5,SLC6A3,DRD2L,GPR143,DRD2B,DRD1B,DRD2,DRD3,TH |
| protein homodimerization activity | HMOX1,UGT1A9,PDGFC,TWIST1,TGFB1,RCHY1,AMBP,BAXB,IL6R,SRF |
| norepinephrine binding | ADRA2A,ADRB3A,ADRB1,ADRB3B |
| adenylate cyclase binding | AKAP5,AKAP6,AKAP12,CALM3,CALM2,CALM1,ADCYAP1R1,CHRNA7 |
| beta2-adrenergic receptor activity | ADRB2A,ADRB2B |
| potassium channel regulator activity | KCNE2,KCNE3,ABCC9,KCNAB2,AMIGO1,PIAS3,ARPP19,KCNIP1,KCNE1,KCNIP3 |
| protein binding | KLC3,Clec4n,STAT4,C1orf105,EEA1,ASB3,NOL3,CUEDC2,HDAC7A,AHSP |
| epinephrine binding | ADRB1,ADRB3A,ADRB3B,ADRA2A,ADRA2C,ADRB2A,ADRB3,ADRB2B,ADRA2B |
Interacting Protein
ADRB2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADRB2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADRB2.
MAGI3;SRC;SLC9A3R1;ARRB2
Resources
Research Area
Neurotransmitter G Protein-Coupled ReceptorsAdrenergic Receptors
Asthma Therapeutic Targets
Related Services
Related Products
References
- Lantsova, VB; Gerasimov, AS; et al. The Role of ADRB2 in Myasthenia: Genetic and Immunological Factors. BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE 154:351-353(2013).
- Hassan, S; Karpova, Y; et al. A pilot study of blood epinephrine levels and CREB phosphorylation in men undergoing prostate biopsies. INTERNATIONAL UROLOGY AND NEPHROLOGY 46:505-510(2014).
