IL1B

  • Official Full Name

    interleukin 1 beta

  • Overview

    Interleukin-1 beta (IL-1β) also known as catabolin, is a cytokine protein that in humans is encoded by the IL1B gene. IL-1β precursor is cleaved by caspase 1 (interleukin 1 beta convertase). Cytosolic thiol protease cleaves the product to form mature IL-1β. This antibody is a human monoclonal anti-human IL1Beta antibody of the IgG1/ Kappa isotype. It binds to human IL1Beta and neutralizes its activity by blocking its interaction with IL1 receptors, but it does not bind IL1α or IL1 receptor antagonist (IL1 ra).

  • Synonyms

    Il1b;RP23-384K11.2;IL-1beta;Il-1b;Catabolin;IL-1;Lymphocyte-activating factor;LAF;Endogenous Pyrogen;EP;Leukocyte Endogenous Mediator;LEM;Mononuclear Cell Factor;MCF;IL1F2, Interleukin-1 beta;pro-interleukin-1-beta;Interleukin-1 beta precursor;preinterleukin 1 beta;H1;Hematopoietin 1;IFN beta inducing factor;IL 1;IL 1 beta;IL 1B;IL-1 beta;IL1 BETA;IL1F2;Interleukin 1 beta;Interleukin 1 beta precursor;Interleukin-1 beta;OAF;Osteoclast activating factor;OTTHUMP00000162031;Preinterleukin beta;Pro interleukin 1 beta;Gene name: IL1B;NM_000576.2;NP_000567.1;UniProt ID: P01584;P01584;2q14;Canakinumab;Ilaris;Entrez: 3553;Entrez Gene: 3553;Gene ID: 3553;MIM: 147720;IL1-BETA

Recombinant Proteins

  • Cynomolgus
  • Human
  • Mouse
  • Rat
  • Pig
  • Feline
  • Cotton Rat
  • Monkey
  • Canine
  • Rabbit
  • Porcine
  • Rhesus macaque
  • Zebrafish
  • Bovine
  • Horse
  • Cattle
  • Dog
  • Guinea pig
  • Sheep
  • Ovine
  • Chicken
  • Golden hamster
  • E.coli
  • Human
  • Monkey
  • CHO
  • C-His
  • Mammalian Cells
  • Yeast
  • HEK293
  • Rabbit
  • Human Cells
  • Non
  • GST
  • His
  • Fc
  • Avi&His
  • His&T7
  • His&S
  • GST&His
  • DDK&Myc
  • Avi&Fc&His
  • Flag&His
  • Flag
  • His&SUMO
  • His&Myc
  • His&SUMO&Trx
  • His&Strep II
Cat.# Product name Source (Host) Species Tag Protein Length Price
IL1B-1167C Active Recombinant Cynomolgus IL1B Protein E.coli Cynomolgus Non 117-269 a.a.
IL1B-02H Recombinant Human IL1B protein E.coli Human Non 153
IL1B-132H Active Recombinant Human IL1B Protein E.coli Human Non 117-269 a.a.
IL1B-14167H Recombinant Human IL1B protein, GST-tagged E.coli Human GST 1-269 aa
Il1b-383M Active Recombinant Mouse Il1b protein E.coli Mouse Non Val118-Ser269
Il1b-384R Recombinant Rat Il1b protein(Met1-Ser268), His-tagged E.coli Rat His Met1-Ser268
IL1B-577R Recombinant Rat IL1B, His tagged E.coli Rat His 117-268 a.a.
IL1B-744H Active Recombinant Human IL1B protein(Met1-Ser269), His-tagged E.coli Human His Met1-Ser269
IL1B-02HP Active Recombinant Human IL1B protein, R-PE labeled E.coli Human 154 aa
IL1B-027E Active Recombinant Human IL1B (117-269aa) E.coli Human Non
Il1b-040E Active Recombinant Mouse Il1b (118-269aa), Met tagged E.coli Mouse Non
IL1B-1024P Recombinant Pig IL1B protein(Ala115-Pro267) E.coli Pig Non 115-267 a.a.
IL1B-1030F Active Recombinant Feline IL1B protein(Ala116-Ser267) E.coli Feline Non Ala116-Ser267
IL1B-23H Active Recombinant Human IL1B E.coli Human Non Full L.
IL1B-339H Active Recombinant Human IL1B Human Human Non
Il1b-390C Active Recombinant Cotton Rat Il1b, Met-tagged E.coli Cotton Rat 116-267 a.a.
IL1B-394M Active Recombinant Monkey Interleukin 1 Beta Monkey Monkey Non
IL1B-461H Active Recombinant Human Interleukin 1, Beta E.coli Human Non
Il1b-462M Recombinant Mouse Il1b protein E.coli Mouse Non 152 amino acids
Il1b-463R Recombinant Rat Il1b protein E.coli Rat Non 153 amino acids
Il1B-464H Active Recombinant Human Il1B, HIgG1 Fc-tagged, mutant CHO Human Fc 117-269 a.a.
IL1B-465H Active Recombinant Human IL1B, MIgG2a Fc-tagged CHO Human Fc 117-269 a.a.
Il1b-603M Active Recombinant Mouse Il1b E.coli Mouse Val118-Ser269
IL1B-656C Active Recombinant Canine IL1B E.coli Canine Non 114-265 a.a.
IL1B-667R Active Recombinant Rabbit IL1B protein(Ala117-Ser268) E.coli Rabbit Non Ala117-Ser268
Il1b-8899M Active Recombinant Mouse Il1b CHO Mouse Non
IL1B-9908H Active Recombinant Human IL1B CHO Human Non
IL1b-01M Active Recombinant Mouse IL1b Protein, His-Tagged E.coli Mouse His
IL1B-01P Active GMP Recombinant Porcine IL1B Protein, His-Tagged E.coli Porcine His
IL1B-1167R Active Recombinant Rhesus IL1B Protein E.coli Rhesus macaque Non Ala117-Ser269
IL1B-1458C Recombinant Cynomolgus IL1B protein, His-tagged C-His Cynomolgus Ala117-Ser268
IL1B-6353H Recombinant Human IL1B protein, His-Avi-tagged E.coli Human Avi&His Ala117-Ser269
IL1B-6744H Recombinant Human IL1B protein, His-Avi-tagged, Biotinylated E.coli Human Avi&His Ala117-Ser269
Il1b-04M Recombinant Mouse Il1b protein E.coli Mouse Non 152
Il1b-105M Recombinant Mouse Interleukin 1 Beta, His-tagged E.coli Mouse His
IL1B-12106Z Recombinant Zebrafish IL1B Mammalian Cells Zebrafish His
IL1B-134H Recombinant Human Interleukin 1, Beta, His-tagged E.coli Human His 117-269 a.a.
IL1B-2239R Recombinant Rhesus monkey IL1B Protein, His-tagged Mammalian Cells Rhesus macaque His
IL1B-232B Recombinant Bovine Interleukin 1, Beta Yeast Bovine Non
IL1B-243C Recombinant Canine Interleukin 1, Beta Yeast Canine Non
IL1B-251E Recombinant Horse IL1B protein E.coli Horse Non 153
IL1B-259F Recombinant Feline Interleukin 1, Beta Yeast Feline Non
Il1b-25C Recombinant Canine IL-1 beta Yeast Canine Non
IL1B-2826C Recombinant Cattle IL1B protein, His & T7-tagged E.coli Cattle His&T7 Met1~Pro266
IL1B-2827D Recombinant Dog IL1B protein, His-tagged E.coli Dog His Cys103~Thr260
IL1B-2828H Recombinant Horse IL1B protein, His-tagged E.coli Horse His His63~Val247
Il1b-2829G Recombinant Guinea pig Il1b protein, His & S-tagged E.coli Guinea pig His&S Thr115~Ser266
Il1b-2830M Recombinant Mouse Il1b protein, His & GST-tagged E.coli Mouse GST&His Val118~Ser269
Il1b-2831M Recombinant Mouse Il1b protein, His & T7-tagged E.coli Mouse His&T7 Val118~Ser269
IL1B-2832S Recombinant Sheep IL1B protein, His & T7-tagged E.coli Sheep His&T7 Met1~Pro266
IL1B-2833P Recombinant Pig IL1B protein, His-tagged E.coli Pig His Val95~Met262
IL1B-2834R Recombinant Rabbit IL1B protein, His & T7-tagged E.coli Rabbit His&T7 Val118~Ser268
IL1B-321H Recombinant Human IL1B, His-tagged E.coli Human His 117-269 a.a.
IL1B-460H Recombinant Human IL1B protein, His-tagged HEK293 Human His Ala117-Ser269
Il1B-466H Recombinant Human Il1B, HIgG1 Fc-tagged CHO Human Fc 1-497 a.a.
Il1b-509M Recombinant Mouse Il1b protein, His-tagged HEK293 Mouse His Val118~Ser269
IL1B-559R Recombinant Rhesus IL1B protein E.coli Rhesus macaque Non 153
IL1b-56O Recombinant Ovine IL-1 beta Yeast Ovine Non
IL1B-589C Recombinant Chicken Interleukin 1, Beta E.coli Chicken Non
IL1B-6093C Recombinant Chicken IL1B Mammalian Cells Chicken His
IL1B-60H Recombinant Human IL1B protein, His-tagged E.coli Human His Ala117~Ser269
IL1B-8135M Recombinant Mouse IL1B Protein Mammalian Cells Mouse His
IL1b-82H Recombinant Human IL-1 beta Yeast Human Non
Il1b-93R Recombinant Rat Il1b protein E.coli Rat Non 153
IL1β-82P Recombinant Porcine Interleukin-1 beta E.coli Pig Non
IL1B-853HCL Recombinant Human IL1B cell lysate Human Non
ADCY3-3532H Recombinant Human ADCY3 protein, His-tagged E.coli Mouse His 470-632 aa
CAB11564RH Rabbit Anti-Human IL1B / IL1F2 Monoclonal Antibody Rabbit Human Non
IL1B-019D Active Recombinant Dog IL1B Protein E.coli Dog
Il1b-030I Active Recombinant Mouse Il1b Protein (153 aa) E.coli Mouse 153
IL1B-059H Active Recombinant Human IL1B Protein E.coli Human 117-269 a.a.
IL1B-05H Active Recombinant Human IL1B Protein, Pre-aliquoted E.coli Human Ala117-Ser269
IL1B-0849H Recombinant Human IL1B Protein (A117-S269), Tag Free E.coli Human Non A117-S269
IL1B-0850H Recombinant Human IL1B Protein (A117-S269), His tagged E.coli Human His A117-S269
Il1b-100M Active Recombinant Mouse Il1b Protein E.coli Mouse
Il1b-1019R Recombinant Rat Il1b Protein, His-tagged HEK293 Rat His Val117-Ser268
IL1B-101I Active Recombinant Human IL1B Protein (153 aa) E.coli Human 153
Il1b-101M Active Recombinant Mouse Il1b Protein E.coli Mouse 118-269 a.a.
Il1b-1020R Recombinant Rat Il1b Protein, His-tagged HEK293 Rat His Val117-Ser268
IL1B-1021C Recombinant Chicken IL1B Protein, His-tagged E.coli Chicken His Ser13-Leu242
IL1B-1022C Recombinant Cattle IL1B Protein, His-tagged E.coli Cattle His Ile109-Val251
IL1B-102HG Active GMP Recombinant Human IL1B Protein E.coli Human
Il1b-102M Active Recombinant Mouse Il1b Protein E.coli Mouse 118-269 a.a.
Il1b-103M Recombinant Mouse Il1b Protein, MYC/DDK-tagged HEK293 Mouse DDK&Myc
IL1B-1170H Recombinant Human IL1B Protein, His (Fc)-Avi-tagged HEK293 Human Avi&Fc&His
IL1B-1170H-B Recombinant Human IL1B Protein Pre-coupled Magnetic Beads HEK293 Human
Il1b-125M Recombinant Mouse interleukin 1 beta Protein, His&Flag tagged E.coli Mouse Flag&His 118-269aa
Il1b-126R Recombinant Rat interleukin 1 beta Protein, Flag tagged E.coli Rat Flag 117-268aa
Il1b-133M Mouse Interleukin-1 beta (rDNA derived) Reference standard Mouse Non
IL1B-150H Active Recombinant Human IL1B Protein E.coli Human
IL1B-151M Active Recombinant Mouse IL1B Protein E.coli Mouse
IL1B-152R Recombinant Rat IL1B Protein E.coli Rat
IL1B-1602H Active Recombinant Human IL1B protein, His-Avi-tagged, Biotinylated HEK293 Human Avi&His 117-269 a.a.
IL1B-1603M Active Recombinant Mouse IL1B protein, His-tagged E.coli Mouse His 118-269 a.a.
Il1b-161M Recombinant Active Mouse IL1B Protein, His-tagged(C-ter) E.coli Mouse His
IL1B-162H Recombinant Active Human IL1B Protein, His-tagged(C-ter) E.coli Human His
IL1B-163H Active Recombinant Human IL1B Protein (Ala117-Ser269), C-His tagged, Animal-free, Carrier-free E.coli Human His Ala117-Ser269
IL1B-163P Recombinant Active Pig IL1B Protein, His-tagged(C-ter) E.coli Pig His
IL1B-1782C Recombinant Chicken IL1B protein, His-tagged E.coli Chicken His Arg110~Lys263
Il1b-180I Active Recombinant Rat Il1b Protein HEK293 Rat
IL1B-205P Active Recombinant Pig IL1B Protein (Ala115-Pro267), C-His tagged, Animal-free, Carrier-free E.coli Pig His Ala115-Pro267
IL1B-2060R Recombinant Rhesus Macaque IL1B Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque Avi&Fc&His
IL1B-2060R-B Recombinant Rhesus Macaque IL1B Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
IL1B-2121H Active Recombinant Human IL1B protein, Fc-tagged HEK293 Human Fc Ala117-Ser269
IL1B-2166C Recombinant Cynomolgus IL1B protein, His-tagged E.coli Cynomolgus His Ala 117 - Ser 268
il1b-2298Z Recombinant Zebrafish il1b Protein, His-tagged E.coli Zebrafish His Met1-Ile273
IL1B-244H Active Recombinant Human IL1B Protein E.coli Human Non
IL1B-2465H Recombinant Human IL1B Protein (Ala117-Ser269), C-His tagged E.coli Human His Ala117-Ser269
IL1B-2466H Recombinant Human IL1B Protein (Ala117-Ser268), His tagged E.coli Human His Ala117-Ser268
Il1b-249I Active Recombinant Mouse Il1b Protein CHO Mouse
IL1B-250I Active Recombinant Human IL1B Protein CHO Human
IL1B-28HG Active Recombinant Human IL1B Protein (Ala117-Ser269), GMP Grade, Animal-Free E.coli Human Ala117-Ser269
IL1B-2918H Recombinant Human IL1B protein(117-269aa), His-tagged E.coli Human His 117-269aa
IL1B-29H Active Recombinant Human IL1B Protein, Animal Free Human Cells Human
IL1B-3096H Recombinant Human IL1B protein, His-SUMO-tagged E.coli Human His&SUMO 117-269aa
IL1B-3097H Recombinant Human IL1B protein, GST-tagged E.coli Human GST 117-269aa
IL1B-3098S Recombinant Sheep IL1B protein, His-tagged E.coli Sheep His 114-266aa
IL1B-313HFL Recombinant Full Length Human IL1B Protein, C-Flag-tagged Mammalian Cells Human Flag Full L.
Il1b-363I Active Recombinant Rat Il1b Protein (152 aa) E.coli Rat 152
IL1B-364H Active Recombinant Human IL1B Protein Human Cells Human Non
IL1B-364I Active Recombinant Pig IL1B Protein (154 aa) E.coli Pig 154
Il1b-365I Active Recombinant Mouse Il1b Protein (153 aa) E.coli Mouse 153
il1b-3668Z Recombinant Zebrafish il1b protein, His-tagged E.coli Zebrafish His 41-272aa
il1b-3669Z Recombinant Zebrafish il1b protein, His&Myc-tagged E.coli Zebrafish His&Myc 41-272aa
IL1B-366I Active Recombinant Human IL1B Protein (153 aa) E.coli Human 153
IL1B-3698H Recombinant Human IL1B protein, Trx-His-SUMO-tagged E.coli Human His&SUMO&Trx 493aa(including fusion tag)
Il1B-39H Recombinant Human Il1B protein, low endotoxin E.coli Human Ala117-Ser269
IL1B-40H Recombinant Human IL1B Protein E.coli Human Full L.
IL1B-4316HG GMP Recombinant Human IL1B protein E.coli Human Non 153
IL1B-4503M Recombinant Mouse IL1B Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
IL1B-4503M-B Recombinant Mouse IL1B Protein Pre-coupled Magnetic Beads HEK293 Mouse
IL1B-52H Recombinant Human IL1B Protein, GST-tagged E.coli Human GST
Il1b-5314M Recombinant Mouse Il1b protein, His-tagged E.coli Mouse His 119-268aa
Il1b-533G Recombinant Golden hamster Il1b protein, His&Strep II-tagged E.coli Golden hamster His&Strep II 1-267a.a.
IL1B-5445S Recombinant Sheep IL1B protein, His-tagged Yeast Sheep His 114-266aa
Il1b-55M Active Recombinant Mouse Il1b Protein (Val118-Ser269), C-His tagged, Animal-free, Carrier-free E.coli Mouse His Val118-Ser269
IL1B-5955H Recombinant Human IL1B Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293 Human DDK&Myc
Il1b-632M Active Recombinant Mouse Il1b Protein E.coli Mouse Non
Il1b-6735M Recombinant Mouse Il1b Protein (Val118-Ser269) E.coli Mouse Non Val118-Ser269
IL1B-69H Recombinant Human IL1B Protein E.coli Human Ala117-Ser269
Il1b-7238M Recombinant Mouse Il1b Protein, His-tagged E.coli Mouse His 118-269
IL1B-82P Recombinant Pig IL1B protein E.coli Pig Non 153
IL1B-83H Human Interleukin-1 Beta (rDNA derived) Reference standard Human Non
IL1B-920C Active Recombinant Canine IL1B Protein (Ala115-Ser266) E.coli Canine Non Ala115-Ser266

    Involved Pathway

    IL1B involved in several pathways and played different roles in them. We selected most pathways IL1B participated on our site, such as MAPK signaling pathway,Cytokine-cytokine receptor interaction,NF-kappa B signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL1B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interaction PRLRA,CD40,TGFBR2,MET,Il2,INHBB,TNFSF8,CXCL12A,CCL21,IL10
    Cytosolic DNA-sensing pathway POLR3H,POLR1C,CCL4L2,IFNB,NFKBIAA,IFNA14,AIM2,POLR3E,IFN-a,MB21D1
    NF-kappa B signaling pathway TNFSF14,LTA,IRAK1,TRAF3,BCL10,BCL2,PRKCB,CD40,LTBR,CFLAR
    Chagas disease (American trypanosomiasis) PPP2R2A,CD3E; CD3D,TLR6,GNAS,MAPK8,AKT2,CCL3L3,TICAM1,NFKB1,PIK3R3
    TNF signaling pathway SOCS3,CXCL1,IL15,TRAF2,PIK3CD,Ccl12,SELE,MLKL,CREB3L2,PIK3R5
    Pertussis IRF3,C4BP,Itgam&Itgb2,GM5077,IRAK1,TNF,MYD88,GNAI1,TICAM2,SERPING1
    Hematopoietic cell lineage CD1D2,CD8B1,CD8B,Kitl,IL3RA,IL2RA,CSF1R,CD1A,IL6,DNTT
    Toll-like receptor signaling pathway Ifna11,IFNA6,TLR1LB,STAT1A,TRAF3,IKBKB,CXCL9,IFNA10,IL12BA,NFKBIAB
    Graft-versus-host disease HLA-G,H2-AB1,HLA-B,H2-Q10,HLA-DOB,Fasl,H2-AA,HLA-DQA1,KIR3DL2,HLA-DRB1

    Protein Function

    IL1B has several biochemical functions, for example, cytokine activity,interleukin-1 receptor binding,protein domain specific binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL1B itself. We selected most functions IL1B had, and list some proteins which have the same functions with IL1B. You can find most of the proteins on our site.

    Function Related Protein
    cytokine activity TNFSF10,CSF1B,CCL38A.4,IL15,NDR1,GDF10,IFNA16,CMTM4,TNFSF15,BMP6
    interleukin-1 receptor binding TLR9,IL1RAP,IL1F10,IL37,IL36A,IL36RN,TLR5,IRAK4,IL1RN,IRAK1
    protein domain specific binding SHROOM2,DICER1,ARFIP1,CEP68,CALM2,BASP1,CBX3,GABRR3,MED12,TNNI3

    Interacting Protein

    IL1B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL1B here. Most of them are supplied by our site. Hope this information will be useful for your research of IL1B.

    IL1RAP;saicar;PKM;IL1R1;A2M;IKBKG;MYC

    Resources

    Gene Families

    Growth Factors

    Research Area

    Neuroinflammation
    Inflammasome
    Inflammatory Mediators
    T Cell Cytokine Signaling
    NOD-like Receptors and the Inflammasome
    Th17 Cells
    Th9 Cells
    IL-1 Family Ligands
    Head and Neck Cancer Biomarkers

    References

    • McDermott, AJ; Higdon, KE; et al. The role of Gr-1(+) cells and tumour necrosis factor-alpha signalling during Clostridium difficile colitis in mice. IMMUNOLOGY 144:704-716(2015).
    • Leal, RF; Planell, N; et al. Identification of inflammatory mediators in patients with Crohn's disease unresponsive to anti-TNF alpha therapy. GUT 64:233-242(2015).

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