Active Recombinant Human IL1B, MIgG2a Fc-tagged
| Cat.No. : | IL1B-465H |
| Product Overview : | The extracellular domain of human IL-1b (NP_000567.1)(Ala117-Ser269) is fused to the N-terminus of the Fc region of mouse IgG2a was expressed in CHO cell. |
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| Description : | The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced byactivated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1(CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety ofcellular activities, including cell proliferation, differentiation, and apoptosis. The induction ofcyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute toinflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine genecluster on chromosome 2. |
| Source : | CHO cell |
| Species : | Human |
| Tag : | MIgG2a Fc-tagged |
| Form : | Lyophilized from 0.2μm-filtered solution in PBS. |
| Bio-activity : | cytokine activity; interleukin-1 receptor binding; protein binding |
| Molecular Mass : | 43KDa (monomer) |
| AA Sequence : | Ala117-Ser269 |
| Endotoxin : | <0.06 eu/μg="" as="" determined="" by="" lal=""> |
| Purity : | >98%, by SDS-PAGE under reducing conditions. |
| Stability : | Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C. |
| Reconstitution : | Reconstitute at 100μg/ml in sterile PBS. |
| Warning : | Avoid freeze/thaw cycles. |
| Protein length : | 117-269 a.a. |
| Gene Name | IL1B interleukin 1, beta [ Homo sapiens ] |
| Official Symbol | IL1B |
| Synonyms | IL1B; interleukin 1, beta; interleukin-1 beta; IL 1B; IL1 BETA; IL1F2; IL-1 beta; catabolin; preinterleukin 1 beta; pro-interleukin-1-beta; IL-1; IL1-BETA; |
| Gene ID | 3553 |
| mRNA Refseq | NM_000576 |
| Protein Refseq | NP_000567 |
| MIM | 147720 |
| UniProt ID | P01584 |
| Chromosome Location | 2q14 |
| Pathway | African trypanosomiasis, organism-specific biosystem; African trypanosomiasis, conserved biosystem; Alzheimers disease, organism-specific biosystem; Alzheimers disease, conserved biosystem; Amoebiasis, organism-specific biosystem; Amoebiasis, conserved biosystem; Apoptosis, organism-specific biosystem; |
| Function | cytokine activity; cytokine activity; growth factor activity; interleukin-1 receptor binding; protein domain specific binding; |
Not For Human Consumption!
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