Il5
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Official Full Name
interleukin 5 -
Overview
This gene encodes a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. The encoded cytokine plays a major role in the regulation of eosinophil formation, maturation, recruitment and survival. The increased production of this cytokine may be related to pathogenesis of eosinophil-dependent inflammatory diseases. This cytokine functions by binding to its receptor, which is a heterodimer, whose beta subunit is shared with the receptors for interleukine 3 (IL3) and colony stimulating factor 2 (CSF2/GM-CSF). This gene is located on chromosome 5 within a cytokine gene cluster which includes interleukin 4 (IL4), interleukin 13 (IL13), and CSF2 . This gene, IL4, and IL13 may be regulated coordinately by long-range regulatory elements spread over 120 kilobases on chromosome 5q31. -
Synonyms
EDF;TRF;IL-5;B Cell Differentiation Factor I;B-cell differentiation factor I;Colony stimulating factor;Colony Stimulating Factor Eosinophil;Eosinophil;Eosinophil Differentiation Factor;IL 5;IL5;IL5_HUMAN;Interleukin 5 (colony stimulating factor, eosinophil);Interleukin 5;Interleukin-5;Interleukin5;T Cell Replacing Factor;T-cell replacing factor
Recombinant Proteins
- Human
- Feline
- Rabbit
- Mouse
- Equine
- Cynomolgus
- Chicken
- Rhesus macaque
- Canine
- Dog
- Pig
- Rat
- Ferret
- Horse
- Cattle
- Insect Cells
- Yeast
- CHO
- Mammalian Cells
- Mouse
- Hordeum Vulgare
- E.coli
- HEK293
- Sf21 Cells
- Human Cells
- Rat
- Insect cells
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- Avi&His
- Fc&His
- Strep II
- His&T7
- GST&His
- LEAF
- mFc
- Avi&Fc&His
- GST
- Fc&Flag
Involved Pathway
Il5 involved in several pathways and played different roles in them. We selected most pathways Il5 participated on our site, such as Cytokine-cytokine receptor interaction,Jak-STAT signaling pathway,Hematopoietic cell lineage, which may be useful for your reference. Also, other proteins which involved in the same pathway with Il5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| ne thyroid disease | H2-Q10,IFNA21,HLA-DRB4,IFNA1,IFNA14,HLA-DPB1,PRF1,HLA-DRB3,IFNA5,H2-AB1 |
| Autoi | HLA-DMA,H2-AA,H2-Q10,Ifna11,HLA-A,TG,IFNA13,HLA-DRB1,IFNA8,IFNA12 |
| Intestinal i | CCL27B,AICDA,CCL25B,CD40LG,LTBR,CD40,CXCR4,MHC2DAB,H2-AA,HLA-DOB |
| Cytokine-cytokine receptor interaction | PLEKHO2,GM13304,CCL17,EDA,IL22RA2,VEGFAB,TGFBR1A,KITLGB,IL28A,CXCL1 |
| Jak-STAT signaling pathway | STAT3,IFNA8,RAF1B,IFNA6,CSH2,IFNA7,IL20RB,BCL2,Ifnlr1,PIAS4A |
| T cell receptor signaling pathway | OXSR1A,NFKBIB,GRAPA,DLG1,PPP3CC,MAPK3,MAPK9,MAP3K7,PIK3CG,GRAP2 |
| ne network for IgA production | CXCR4B,BMA1,CD28,IL6,MAP3K14,HLA-DMA,HLA-DOB,MHC2DAB,IL-15RA,CCL28 |
| Hematopoietic cell lineage | CD19,ANPEP,CD1C,GP1BB,Itga10&Itgb1,FLT3LG,HLA-DRB5,GP1BA,CD3D,CD8A |
| Allograft rejection | HLA-DRA,HLA-DRB4,H2-AA,CD40LG,PRF1,Fasl,HLA-DOB,HLA-DQA2,HLA-B,HLA-A |
Protein Function
Il5 has several biochemical functions, for example, cytokine activity,growth factor activity,interleukin-5 receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Il5 itself. We selected most functions Il5 had, and list some proteins which have the same functions with Il5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| growth factor activity | GSDF,PGF,EPGN,BMP1,GMFB,BMP10,GDF2,INHBA,LIF,INHA |
| protein binding | BCL9,INTS3,UBE2I,Artn,DZIP3,GNG12,SLC3A2,E2F7,BMPR1A,GGN |
| cytokine activity | IFNPHI3,INHBC,NODAL,CMTM7,Ccl12,VEGFA,IL36G,NRG1,Il1f8,AREG |
| interleukin-5 receptor binding | SDCBP |
Interacting Protein
Il5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Il5 here. Most of them are supplied by our site. Hope this information will be useful for your research of Il5.
CSF2RB;IL5RA
Resources
Research Area
Inflammatory MediatorsGranulocyte Markers
gamma delta T Cells
T Cell Cytokine Signaling
CD Antigen (Granulocyte Markers)
Other Interleukins & Receptors
Common β Chain Receptor Family Ligands
T Follicular Helper (Tfh) Cells
Th2 Cells
Related Services
Related Products
References
- Hemmerle, T; Zgraggen, S; et al. Antibody-mediated delivery of interleukin 4 to the neo-vasculature reduces chronic skin inflammation. JOURNAL OF DERMATOLOGICAL SCIENCE 76:96-103(2014).
- Hou, S; Landego, I; et al. Follicular dendritic cell secreted protein FDC-SP controls IgA production. MUCOSAL IMMUNOLOGY 7:948-957(2014).
