Recombinant Human IL5 Protein, His-tagged

• Cat.No.: IL5-76H
• Product Overview: Recombinant Human Interleukin-5 is produced by our Mammalian expression system and the target gene encoding Ile20-Ser134 is expressed with a 6His tag at the C-terminus.

Specification

• Species: Human
• Source: Human Cells
• Tag: His
• Protein Length: 20-134 a.a.
• Description: IL-5 is expressed in eosinophils, NK cells, TC2 CD8+ T cells, mast cells, CD45+ CD4+ T cells, gamma delta T cells and IL-1 beta activated endothelial cells. IL-5 acts as a growth and differentiation factor for both B cells and eosinophils. Relative to B cells, IL-5 appears to induce the differentiation of activated conventional B-2 cells into Ig-secreting cells. In addition, it induces the growth of B-1 progenitors as well as IgM production by B-1 cells.IL-5 appears to perform a number of functions on eosinophils. These include the down modulation of Mac-1,the upregulation of receptors for IgA and IgG,the stimulation of lipid mediator (leukotriene C4 and PAF) secretion and the induction of granule release.IL-5 also promotes the growth and differentiation of eosinophils.
• Molecular Mass: Predicted Molecular Weight: 14.2kDa
  Apparent Molecular Weight: 20kDa, reducing conditions.
• AA Sequence: Ile20-Ser134
• Endotoxin: Less than 0.1 ng/ug (1 EU/ug).
• Purity: >90%
• Storage: Lyophilized protein should be stored at < -20 centigrade, though stable at room temperature for 3 weeks.
  Reconstituted protein solution can be stored at 4-7 centigrade for 2-7 days.
  Aliquots of reconstituted samples are stable at < -20 centigrade for 3 months.
• Reconstitution: Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
  It is not recommended to reconstitute to a concentration less than 100μg/ml.
  Dissolve the lyophilized protein in distilled water.
  Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
• Quality Statement: Purity: Greater than 90% as determined by reducing SDS-PAGE.
• Shipping: The product is shipped at ambient temperature.
  Upon receipt, store it immediately at the temperature listed below.

Gene Information

• Gene Name: IL5 interleukin 5 [ Homo sapiens (human) ]
• Official Symbol: IL5
• Synonyms: Interleukin-5; IL-5; B-cell differentiation factor I; Eosinophil differentiation factor; T-cell replacing factor; IL5; EDF; TRF; IL-5
• Gene ID: 3567
• mRNA Refseq: NM_000879.3
• Protein Refseq: NP_000870.1
• MIM: 147850
• UniProt ID: P05113