Active Recombinant Human IL5 Protein, His-Tagged

• Cat.No.: IL5-01H
• Product Overview: Recombinant Human IL5 Protein, His-Tagged was expressed in Baculovirus cell line

Specification

• Species: Human
• Source: Insect Cells
• Tag: His
• Protein Length: 124aa
• Description: This gene encodes a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. The encoded cytokine plays a major role in the regulation of eosinophil formation, maturation, recruitment and survival. The increased production of this cytokine may be related to pathogenesis of eosinophil-dependent inflammatory diseases. This cytokine functions by binding to its receptor, which is a heterodimer, whose beta subunit is shared with the receptors for interleukine 3 (IL3) and colony stimulating factor 2 (CSF2/GM-CSF). This gene is located on chromosome 5 within a cytokine gene cluster which includes interleukin 4 (IL4), interleukin 13 (IL13), and CSF2 . This gene, IL4, and IL13 may be regulated coordinately by long-range regulatory elements spread over 120 kilobases on chromosome 5q31.
• Form: Liquid
• Bio-activity: Measured in a cell proliferation assay using TF-1 human erythroleukemic cells. The ED50 range ≤1.5ng/ml.
• Molecular Mass: 14.2 kDa
• Endotoxin: < 1 EU per 1ug of protein (determined by LAL method)
• Purity: > 90% by SDS-PAGE
• Applications: SDS-PAGE, Bioactivity
• Storage: Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20°C to -80°C. Avoid repeated freezing and thawing cycles.
• Concentration: 0.5mg/ml (determined by absorbance at 280nm)
• Storage Buffer: Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Gene Information

• Gene Name: IL5 interleukin 5 [ Homo sapiens (human) ]
• Official Symbol: IL5
• Synonyms: Interleukin-5, IL-5, EDF, TRF
• Gene ID: 3567
• mRNA Refseq: NM_000879.3
• Protein Refseq: NP_000870.1
• MIM: 147850
• UniProt ID: P05113