Active Recombinant Mouse Interleukin-5

• Cat.No.: IL5-412M
• Product Overview: Interleukin-5 Mouse Recombinant produced in E.Coli is a dimeric, non-glycosylated polypeptide chain containing 2 x 113 amino acids forming a disulfide linked homodimer and having a molecular mass of 26.2 kDa. The Mouse IL-5 is purified by proprietary chromatographic techniques.

Specification

• Cat. No.: IL5-412M
• Description: The protein encoded by this gene is a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. This cytokine is a main regulator of eosinopoiesis, eosinophil maturation and activation. The elevated production of this cytokine is reported to be related to asthma or hypereosinophilic syndromes. The receptor of this cytokine is a heterodimer, whose beta subunit is shared with the receptors for interleukine 3 (IL3) and colony stimulating factor 2 (CSF2/GM-CSF). This gene, together with those for interleukin 4 (IL4), interleukin 13 (IL13), and CSF2, form a cytokine gene cluster on chromosome 5. This cytokine, IL4, and IL13 are found to be regulated coordinately by long-range regulatory elements spread over 120 kilobases on chromosome 5q31.
• Source: Mouse
• Host: Escherichia Coli.
• Form: Lyophilized from a concentrated (1mg/ml) solution containing 20mM Sodium Phosphate and 50mM NaCl pH-7.5.
• Purity: Greater than 97.0% as determined by (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
• Bio-activity: The ED50 as determined by the dose-dependant stimulation of the proliferation of TF-1 cells was found to be 1.7ng/ml, corresponding to a specific activity of 588,235.3IU/mg.
• Physical Appearance: Sterile Filtered White lyophilized (freeze-dried) powder.
• Solubility: It is recommended to reconstitute the lyophilized Mouse Interleikin-5 in sterile 18Mμ-cm H2O at a concentration of 100µg/ml, which can then be further diluted to other aqueous solutions.
• Amino acid sequence: MEIPMSTVVK ETLTQLSAHR ALLTSNETMR LPVPTHKNHQ LCIGEIFQGL DILKNQTVRG GTVEMLFQNL SLIKKYIDRQ KEKCGEERRR TRQFLDYLQE FLGVMSTEWA MEG.
• Storage: Lyophilized Mouse Interleukin-5 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Mouse IL5 should be stored at 4°C between 2-7 days and for future use below -18°C. Please avoid freeze thaw cycles.
• Tag: Non

Gene Information

• Gene Name: Il5 interleukin 5 [ Mus musculus ]
• Official Symbol: IL5
• Synonyms: interleukin-5; TRF; BCGF-II; OTTMUSP00000005818; B-cell growth factor II; T-cell replacing factor; cytotoxic T-lymphocyte inducer; eosinophil differentiation factor
• Gene ID: 16191
• mRNA Refseq: NM_010558
• Protein Refseq: NP_034688
• UniProt ID: P04401
• Chromosome Location: 11 A5/B1; 11 29.2 cM
• Pathway: Allograft rejection; Autoimmune thyroid disease; Fc epsilon RI signaling pathway; Intestinal immune network for IgA production; Jak-STAT signaling pathway
• Function: cytokine activity; growth factor activity; interleukin-5 receptor binding

Reviews

07/26/2022

High efficacy and safety in clinical treatment.

06/22/2022

There are no structural or functional defects.

01/31/2019

The stability and activity are maintained well during long-term storage.

Q&As

Which effect of IL5 in the treatment of tuberous sclerosis?

Inhibit the creatinine kinase level in the blood of patients with tuberous sclerosis, reduce the inflammatory response, and improve the quality of life of patients.

Does there have any effect of IL5 in the treatment of allergic rhinitis?

IL5 can reduce the number of eosinophils in the nasal mucosa of patients with allergic rhinitis, reducing the symptoms of allergic reactions, such as sneezing, runny nose and nasal congestion.

What is the main function of IL5?

Stimulate the proliferation and differentiation of white blood cells, promote the function of the immune system, and is used to treat diseases such as asthma, allergic rhinitis, nodular sclerosis and some malignant tumors.

Does IL5 have side effects?

Cause mild side effects such as headache, nausea, vomiting, and serious side effects such as allergic reactions if the dose is too large or allergic.

Can IL5 be administered orally?

IL5 cannot be administered orally, only by injection or intravenous drip.

What is the effect of IL5 in the treatment of asthma?

IL5 can reduce the number of eosinophils in the lungs of asthma patients, reduce the frequency and severity of asthma attacks, and improve the quality of life of patients.