Other Interleukins & Receptors

Available Resources for Other Interleukins & Receptors Research

Creative BioMart provides a diverse array of products related to other interleukins and receptors to aid researchers in their studies. Our product line includes recombinant proteins, protein-pre-coupled magnetic beads, cell and tissue lysates, and more, all carefully crafted to cater to the specific requirements of researchers across various fields.

In addition to our extensive product range, we are committed to providing a wealth of knowledge on interleukins and receptors. Our resources cover key topics such as pathways, protein functions, interacting proteins, related articles, and research areas, offering valuable insights for researchers seeking to enhance their understanding of these molecules and their critical roles in physiological processes.

Our Featured Products

Cat.#	Product name	Species	Source (Host)	Tag
IL3-378H	Recombinant Human IL3, His tagged	Human	Insect Cell	His
IL5-4361R	Recombinant Rabbit IL5 Protein	Rabbit	Yeast	N/A
IL13-370H	Active Recombinant Human IL13	Human	CHO	N/A
IL16-14152H	Recombinant Human IL16, His-tagged	Human	E.coli	His
IL32-156H	Recombinant Human IL32 protein(Met1-Lys131), His-tagged	Human	HEK293	C-His
IL34-179H	Recombinant Human Interleukin 34, GST-tagged	Human	E.coli	GST
IL5RA-3834H	Active Recombinant Human IL5RA protein, His-tagged	Human	HEK293	His
CXCL8-3703H	Recombinant Human CXCL8 protein, GST-tagged	Human	E.coli	GST
CSF2RA-724H	Recombinant Human CSF2RA protein, Fc-tagged	Human	HEK293	human/IgG1/Fc
CSF2RB-3177H	Active Recombinant Human CSF2RB protein, His-tagged	Human	HEK293	His
TXLNA-2892H	Recombinant Human TXLNA protein, His-tagged	Human	E.coli	His

About Other Interleukins & Receptors

Interleukins are a large group of cytokines that play a critical role in the regulation of the immune response and inflammation. In addition to the well-known interleukins such as IL-1, IL-2, IL-6, IL-10, IL-12, and IL-17, there are many other interleukins and their corresponding receptors that are involved in various immune functions.

• Several other interleukins play important roles in regulating the immune response, including IL-3, IL-5, IL-8, IL-13, IL-16, IL-32, and IL-34. These interleukins can have both pro-inflammatory and anti-inflammatory effects, depending on the circumstances under which they are produced.
• The receptors for these interleukins, including CXCL8, CSF2RA, CSF2RB, IL5RA, and TXLNA, are typically found on the surface of immune cells such as T cells, B cells, and macrophages. When an interleukin binds to its receptor, it triggers a signaling cascade that leads to the activation of various immune responses. This intricate system helps to regulate the immune system's response to pathogens and maintain a healthy balance between inflammation and anti-inflammatory processes.

Understanding the functions of these other interleukins and their receptors is crucial in the development of novel therapeutic strategies for immune-mediated diseases, such as autoimmunity and cancer. Overall, the study of other interleukins and receptors expands our knowledge of the complex regulatory mechanisms that govern the immune response.

Research Methods and Progress of Other Interleukins and Receptors in Related Diseases

• Receptor Binding and Signaling Pathways: Understanding the binding interactions between interleukins and their receptors is essential for studying their functional roles. Various techniques, such as surface plasmon resonance (SPR), co-immunoprecipitation, and ligand-receptor binding assays, are used to characterize the binding kinetics and affinity between interleukins and their receptors. Signal transduction pathways activated by IL-receptor binding can be investigated using techniques like Western blotting, immunofluorescence, and phosphoproteomics.
• Gene Expression Analysis: Studying the regulation of interleukin gene expression provides insights into their roles in health and disease. Techniques like quantitative PCR (qPCR), RNA sequencing (RNA-seq), and microarray analysis can be used to measure the expression levels of interleukin genes in different cell types, tissues, or disease conditions. These methods help identify dysregulated interleukin expression patterns associated with diseases and provide potential therapeutic targets.
• Immunohistochemistry and Immunofluorescence: Immunohistochemistry (IHC) and immunofluorescence (IF) techniques enable the visualization and localization of interleukins and their receptors in tissues and cells. Antibodies specific to target interleukins or receptors are used to detect their expression and distribution. IHC and IF can provide insights into the cellular localization and heterogeneity of interleukin expression within tissues, aiding in the characterization of their roles in disease progression.
• Functional Assays and Cell-based Models: Functional assays are employed to investigate the biological effects of interleukins on target cells and their involvement in disease processes. These assays include cell proliferation assays, migration assays, cytokine release assays, and cell signaling pathway analysis. Primary cells, cell lines, and genetically modified models are used to study the impact of interleukins on cellular behavior and disease phenotypes.
• Therapeutic Targeting: Advances in understanding interleukins biology and their roles in diseases have led to the development of targeted therapies. Monoclonal antibodies that specifically block interleukin-receptor interactions or neutralize interleukins have been developed as therapeutic agents. Additionally, small molecule inhibitors targeting intracellular signaling pathways downstream of interleukin receptors are being explored for therapeutic intervention.
• Disease Associations and Therapeutic Applications: Many diseases, including autoimmune disorders, inflammatory conditions, and certain cancers, are associated with dysregulated interleukin signaling. Investigating the involvement of interleukins and their receptors in these diseases can provide insights into disease mechanisms and potential therapeutic strategies. Advances in understanding the IL signaling network have led to the development of immunomodulatory therapies targeting specific interleukins or their receptors.

Fig.2 Schematic representation of the three receptors that bind IL-4, IL-13, or both. (Marone G, 2019)

If you have any questions, requirements, or cooperation intentions, please feel free to contact us. We very much look forward to working with you and helping you achieve research and commercial success.

Related Reference

1. Marone G, Granata F, Pucino V, et al. The Intriguing Role of Interleukin 13 in the Pathophysiology of Asthma. Front Pharmacol. 2019;10:1387.