IGF1

  • Official Full Name

    Insulin-like growth factor 1

  • Overview

    Insulin-like growth factor 1 (IGF-1) also known as somatomedin C is a protein that in humans is encoded by the IGF1 gene. IGF-1 has also been referred to as a "sulfation factor" and its effects were termed "nonsuppressible insulin-like activity" (NSILA) in the 1970s. IGF-1 is a hormone similar in molecular structure to insulin. It plays an important role in childhood growth and continues to have anabolic effects in adults. A synthetic analog of IGF-1, mecasermin is used for the treatment of growth failure. IGF-1 consists of 70 amino acids in a single chain with three intramolecular disulfide bridges. IGF-1 has a molecular weight of 7649 daltons.

  • Synonyms

    ProIGF-I;Insulin-like Growth Factor-I Precursor;IGF-IEB;IGF1;IGFI;Insulin-like Growth Factor-I;insulin-like growth factor 1 (somatomedin C);insulin-like growth factor 1;IGF1A;insulin-like growth factor I;Mechano growth factor;insulin-like growth factor IA;IGF-I;insulin-like growth factor IB;MGF;somatomedin-C;IGF-IA;IBP1;IGF-IB;Somatomedin-C;IGFI;Teprotumumab;89957-37-9;Ganitumab;905703-97-1

Recombinant Proteins

  • Human
  • Rat
  • Chicken
  • Mouse
  • Bovine
  • Rhesus macaque
  • Cattle
  • Pig
  • Rabbit
  • Gilthead Seabream
  • Zebrafish
  • Porcine
  • Guinea pig
  • Dog
  • E.coli
  • Rice Grain
  • CHO
  • Human
  • E. coli
  • Oryza Sativa
  • Yeast
  • HEK293
  • Mammalian Cell
  • HEK293F
  • Hordeum Vulgare
  • HEK293T
  • Mammalian cells
  • Synthetic Peptide
  • Non
  • Fc
  • His
  • His&NusA
  • GST
  • HQ
  • His&GST
  • His&T7
  • Myc&DDK
  • His&Avi
  • Fc&Avi
  • His&Fc
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
IGF1-06H Recombinant Human IGF1 protein E.coli Human Non 70
IGF-08H Recombinant Human Long Arg3 Insulin-like Growth Factor-I E.coli Human Non
IGF1-057H Active Recombinant Human IGF1 Protein E.coli Human 49-118 a.a.
IGF1-026E Active Recombinant Human IGF1 (26-95aa) E.coli Human Non
IGF1-09H Active Recombinant Human IGF1 protein Rice Grain Human Non
Igf1-173R Active Recombinant Rat Igf1 E.coli Rat Non
IGF1-322C Active Recombinant Chicken Insulin-Like Growth Factor 1 (Somatomedin C) E.coli Chicken Non
IGF1-325H Active Recombinant Human Des(1-3)Insulin-like Growth Factor 1 Human Non
IGF1-526H Active Recombinant Human IGF1 E.coli Human Non
IGF1-650H Active Recombinant Human Insulin Like Growth Factor-I, HIgG1 Fc-tagged, mutant CHO Human Fc 26-130 a.a.
IGF1-651H Active Recombinant Human Insulin Like Growth Factor-I, MIgG2a Fc-tagged CHO Human Fc 26-130 a.a.
IGF1-652H Active Recombinant Human Insulin Like Growth Factor-I,HIgG1 Fc-tagged CHO Human Fc 26-130 a.a.
IGF1-658H Active Recombinant Human Insulin-like Growth Factor 1 Human Human Non 4-70 a.a.
Igf1-01M Active GMP Recombinant Mouse Igf1 Protein, His-Tagged E.coli Mouse His
Igf1-02B Recombinant Bovine Igf1 Protein, Gly50-Ala119 E. coli Bovine Gly50-Ala119
IGF1-08H Active Recombinant HumanIGF1 Protein, HSA Conjugated Oryza Sativa Human Non
IGF1-19HG Active Recombinant Human IGF1 Protein (Gly49-Ala118, Glu51Arg), GMP Grade, Animal-Free E.coli Human Gly49-Ala118, Glu51Arg
IGF1-55H Active Recombinant Human IGF1 protein (Gly49-Ala118(Glu 51 Arg)) Yeast Human 49-118 a.a.
IGF1-810HG Active GMP Recombinant Human IGF1 protein E.coli Human Non
IGF1-036H Recombinant Human IGF1 Protein HEK293 Human Non 49-118 a.a.
IGF1-1203C Recombinant Chicken IGF1 Mammalian Cell Chicken His
IGF1-2215R Recombinant Rhesus monkey IGF1 Protein, His-tagged Mammalian Cell Rhesus macaque His
IGF1-456H Recombinant Human Insulin-like Growth Factor 1 (Somatomedin C) Yeast Human Non
IGF1-471H Recombinant Human IGF1 protein, His-tagged HEK293F Human His Gly49~Ala118
IGF1-524H Recombinant Human IGF1 protein E.coli Human Non 67
IGF1-527H Recombinant Human IGF1 protein E.coli Human Non 83
IGF1-561H Recombinant Human IGF1, His & NusA tagged E.coli Human His&NusA 49-118 a.a.
Igf1-570M Recombinant Mouse Igf1 protein E.coli Mouse Non 70
Igf1-590R Recombinant Rat Igf1 protein E.coli Rat Non 70
Igf1-604R Recombinant Rat Insulin-Like Growth Factor 1 E.coli Rat Non
IGF1-606H Recombinant Human Insulin-Like Growth Factor 1 (somatomedin C) Hordeum Vulgare Human Non
IGF1-60H Active Recombinant Human IGF1 protein(Gly49-Ala118) E.coli Human Non Gly49-Ala118
IGF1-61H Recombinant Human IGF1 Yeast Human Non 49-118 a.a.
IGF1-657H Recombinant Human Insulin-Like Growth Factor 1, GST-tag Human Human GST
IGF1-687H Recombinant Human Insulin-Like Growth Factor 1 (somatomedin C) E.coli Human Non
IGF1-691H Recombinant Human Insulin-Like Growth Factor 1 (somatomedin C), HQ-tagged Hordeum Vulgare Human HQ
IGF1-8063M Recombinant Mouse IGF1 Protein Mammalian Cell Mouse His
IGF1-808C Recombinant Cattle IGF1 protein, His & GST-tagged E.coli Cattle His&GST Thr53~Lys132
IGF1-809C Recombinant Chicken IGF1 protein, His & GST-tagged E.coli Chicken His&GST Ser28~Met153
IGF1-810H Recombinant Human IGF1 protein, His & GST-tagged E.coli Human His&GST Gly49~Ala118
Igf1-811M Recombinant Mouse Igf1 protein, His-tagged E.coli Mouse His Gly33~Ala102
Igf1-812M Recombinant Mouse Igf1 protein, His & T7-tagged E.coli Mouse His&T7 Gly49~Met153
IGF1-813P Recombinant Pig IGF1 protein, GST-tagged E.coli Pig GST Gly49~Ala118
Igf1-814R Recombinant Rat Igf1 protein, His & GST-tagged E.coli Rat His&GST Gly23~Ala92
IGF1-815R Recombinant Rabbit IGF1 protein, His & GST-tagged E.coli Rabbit His&GST Gly33~Lys143
IGF1-84G Recombinant Gilthead Seabream Insulin-Like Growth Factor 1 E.coli Gilthead Seabream Non
IGF1-9334Z Recombinant Zebrafish IGF1 Mammalian Cell Zebrafish His
IGF1-5268HCL Recombinant Human IGF1 293 Cell Lysate HEK293 Human Non
Igf1-01B Recombinant Bovine Igf1 Protein Yeast Bovine
IGF1-01P GMP Recombinant Porcine IGF1 Protein, His-Tagged E.coli Porcine His
IGF1-020H Recombinant Human IGF1 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 Human Myc&DDK
IGF1-0242H Active Recombinant Human IGF1 protein, His-Avi-tagged, Biotinylated HEK293 Human His&Avi 49-118 a.a.
IGF1-0243H Active Recombinant Human IGF1 protein, His-tagged HEK293 Human His 49-118 a.a.
IGF1-0244M Active Recombinant Mouse IGF1 protein, Fc-tagged HEK293 Mouse Fc 49-118 a.a.
IGF1-0245H Active Recombinant Human IGF1 protein, Avi-Fc-tagged, Biotinylated HEK293 Human Fc&Avi 49-118 a.a.
IGF1-0246H Active Recombinant Human IGF1 protein, Fc-tagged HEK293 Human Fc 49-118 a.a.
IGF1-053H Recombinant Human IGF1 Protein E.coli Human 195
IGF1-05H Recombinant Human IGF1 Protein, GST tagged, GFP Labeled E. coli Human GST
Igf1-079M Active Recombinant Mouse Igf1 Protein E.coli Mouse 49-118 a.a.
Igf1-080M Active Recombinant Mouse Igf1 Protein E.coli Mouse
Igf1-081M Recombinant Mouse Igf1 Protein, MYC/DDK-tagged HEK293T Mouse Myc&DDK
IGF1-085I Active Recombinant Human LR3IGF1 Protein (83 aa) E.coli Human 83
IGF1-086I Active Recombinant Human LR3IGF1 Protein (83 aa) E.coli Human 83
IGF1-109H Recombinant Human Insulin-like growth Factor 1 Reference standard Yeast Human Non
IGF1-109I Active Recombinant Human IGF1 Protein (70 aa) E.coli Human 70
IGF1-119H Active Recombinant Human IGF1 Protein E.coli Human
Igf1-120M Active Recombinant Mouse IGF1 Protein E.coli Mouse
IGF1-121R Recombinant Rat IGF1 Protein E.coli Rat
IGF1-124HG GMP Recombinant Human IGF1 protein E.coli Human Non 70
IGF1-126H Recombinant Active Human IGF1 Protein, Fc-His-tagged(C-ter) HEK293 Human His&Fc Gly49-Ala118
IGF1-127H Recombinant Active Human IGF1 Protein, His-tagged(C-ter) E.coli Human His
Igf1-128M Recombinant Active Mouse IGF1 Protein, His-tagged(C-ter) E.coli Mouse His
IGF1-137H Active Recombinant Human IGF1 Protein E.coli Human Gly49-Ala118
IGF1-140H Recombinant Human IGF1 Protein E.coli Human 49-118 a.a.
IGF1-158H Active Recombinant Human IGF1 Protein (Gly49-Ala118), C-His tagged, Animal-free, Carrier-free E.coli Human His Gly49-Ala118
Igf1-1654M Recombinant Mouse Igf1 Protein, His-tagged E.coli Mouse His Gly49-Met153
IGF1-175H Insulin-like growth Factor I Reference standard Human Non
IGF1-2036R Recombinant Rhesus Macaque IGF1 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque His&Fc&Avi
IGF1-2036R-B Recombinant Rhesus Macaque IGF1 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
IGF1-210P Recombinant Pig IGF1 Protein (Gly49-Ala118), C-His tagged, Animal-free, Carrier-free E.coli Pig His Gly49-Ala118
IGF1-21H Active Recombinant Human IGF1 Protein, Pre-aliquoted E.coli Human Gly49-Ala118
IGF1-22H Recombinant Human/Bovine/Porcine IGF1 Protein E.coli Human
IGF1-23H Active Recombinant Human IGF1 Protein E.coli Human
IGF1-2503H Recombinant Human IGF1 Protein (Met1-Ala118), C-Fc tagged Mammalian cells Human Fc Met1-Ala118
IGF1-2504H Recombinant Human IGF1 Protein (Gly49-Ala118), N-Fc tagged Mammalian cells Human Fc Gly49-Ala118
IGF1-2505H Recombinant Human IGF1 Protein (Gly49-Ala118), C-His tagged E.coli Human His Gly49-Ala118
IGF1-2692R Recombinant Rhesus monkey IGF1 Protein, His-tagged E.coli Rhesus macaque His Gly49-Ala118
Igf1-2817G Recombinant Guinea pig Igf1 Protein, His-tagged, OVA Conjugated Synthetic Peptide Guinea pig His
IGF1-29HG Active Recombinant Human IGF1 Protein (Gly49-Ala118), GMP Grade, Animal-Free E.coli Human Gly49-Ala118
IGF1-339I Active Recombinant Human LR3IGF1 Protein (Receptor Grade) E.coli Human
Igf1-374I Active Recombinant Rat Igf1 Protein (71 aa) E.coli Rat 71
Igf1-375I Active Recombinant Mouse Igf1 Protein (71 aa) E.coli Mouse 71
IGF1-376I Active Recombinant Human IGF1 Protein (70 aa) E.coli Human 70
IGF1-377I Active Recombinant Human IGF1 Protein (71 aa) E.coli Human 71
IGF1-384H Recombinant Human IGF1 protein, Fc-tagged HEK293 Human Fc 70
IGF1-3928H Recombinant Human IGF1 protein E.coli Human Non 70
IGF1-4120H Recombinant Human IGF1 protein, His-tagged E.coli Human His 49-118aa
IGF1-4121H Recombinant Human IGF1 protein, GST-tagged E.coli Human GST 49-118aa
IGF1-4256H Recombinant Human IGF1 Protein (Met1-Ala118), C-Fc tagged Mammalian cells Human Fc Met1-Ala118
IGF1-437M Recombinant Mouse IGF1 protein(Gly49-Ala118) Yeast Mouse Non Gly49-Ala118
Igf1-43M Active Recombinant Mouse Igf1 Protein (Gly49-Ala118), C-His tagged, Animal-free, Carrier-free E.coli Mouse His Gly49-Ala118
IGF1-4460M Recombinant Mouse IGF1 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
IGF1-4460M-B Recombinant Mouse IGF1 Protein Pre-coupled Magnetic Beads HEK293 Mouse
IGF1-4644B Recombinant Bovine IGF1 protein, hFc-tagged Yeast Bovine Fc 50-119aa
IGF1-558H Recombinant Human IGF1 Protein, Fc-tagged HEK293 Human Fc 195
IGF1-867HG Active GMP Recombinant Human IGF1 protein, Fc-tagged HEK293 Human Fc DNA sequence encoding Human IGF-1(NP_001104754.1) was expressed with Fc tag at the C-terminal.
IGF1-868HG Active GMP Recombinant Human IGF1 protein HEK293 Human DNA sequence encoding Human IGF-1 LR 3(UniProtKB/Swiss-Prot: P05019) was expressed with His tag at the C-terminal.
IGF1-986D Recombinant Dog IGF1 Protein, His&GST-tagged E.coli Dog His&GST Val22-Met153
IGF1-P059H Recombinant Human IGF1 therapeutic protein(Mecasermin) E.coli Human Non 70 Aa

    Involved Pathway

    IGF1 involved in several pathways and played different roles in them. We selected most pathways IGF1 participated on our site, such as Ras signaling pathway,Rap signaling pathway,HIF- signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IGF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Hypertrophic cardiomyopathy (HCM) SGCG,DMD,ITGA1,CACNB3,ITGB1,SGCA,TNNI3,MYL2,Itga10&Itgb1,CACNA2D4
    FoxO signaling pathway PRKAA1,PIK3R1,KLF2,INS1,GADD45B,SIRT1,PRKAB2,HOMER1B,NLK,EGFRA
    Ras signaling pathway FGF6,KITLG,PIK3R2,FGF4,PAK1,GNG12,GNG13,RRAS2,LOC608458,ZAP70
    Pathways in cancer GNAI3,Adcy4,SKP2,RALB,BAD,GNGT2,PLCG2,RHOA,ARHGEF12,PTGS2
    Dilated cardiomyopathy ITGB1,ITGB7,ITGA6,TTN,ITGA9,MYH7,GNAS,ITGA5,ADRB1,PLN
    p signaling pathway TSC2,BIDA,SIAH1A,BAI1,TP73,TP53AIP1,PTEN,TNFRSF10B,ATM,THBS1
    Aldosterone-regulated sodium reabsorption PIK3CA,PIK3R1,MAPK3,KCNJ1,INS2,PIK3R3,ATP1A1,ATP1A3,PIK3CD,FXYD4
    Melanoma FGF13,BRAF,PIK3R3,FGF18,FGF19,MAPK3,FGF8,PDGFD,FGF6,CDH1
    PIK-Akt signaling pathway PGF,Gh,FGF5,TNC,GNB2,PPP2R5C,TCL1B1,TEK,FIGF,IFNA1

    Protein Function

    IGF1 has several biochemical functions, for example, growth factor activity,hormone activity,insulin receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IGF1 itself. We selected most functions IGF1 had, and list some proteins which have the same functions with IGF1. You can find most of the proteins on our site.

    Function Related Protein
    insulin-like growth factor receptor binding IGF2,ARRB1,YWHAH,IGF2B,Ren1,REN,GNAS,IRS1,INSL4,SOCS2
    growth factor activity GDNF,FGF4,BMP1,BTC,EFEMP1,PDGFD,GSDF,BMP2B,PDGFC,NDP
    protein binding CITED2,MED20,TICAM2,WDR25,LRRK1,SERP1,HMGB1,SMAD4,PAK6,PIN1
    insulin receptor binding GRB10,FRS3,IGF2,FRS2B,DOK5,DOK1B,IRS1,PTPN11,SHC1,INSL3
    hormone activity CSH2,APLN,VIP,INS,SCT,GCGB,Retnla,IGF2A,INSB,INSL5B
    integrin binding WISP1A,ICAM3,ADAM2,CD151,ICAM2,L1CAM,VCAM1,EMP2,ICAM4,CXADR

    Interacting Protein

    IGF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IGF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of IGF1.

    IGF1R;Igfbp5;INSR

    Resources

    Gene Families

    Growth Factors

    Research Area

    Serine Proteases and Regulators
    Endocrine Regulation of Lipid Metabolism
    gamma delta T Cells
    Macrophage Marker CD Antigen
    Insulin-like Growth Factor (IGF)
    Macrophage Markers
    IGF Ligands

    References

    • Luque, RM; Ibanez-Costa, A; et al. Truncated somatostatin receptor variant sst5TMD4 confers aggressive features (proliferation, invasion and reduced octreotide response) to somatotropinomas. CANCER LETTERS 359:299-306(2015).
    • Schofl, C; Grussendorf, M; et al. Failure to achieve disease control in acromegaly: cause analysis by a registry-based survey. EUROPEAN JOURNAL OF ENDOCRINOLOGY 172:351-356(2015).

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