Recombinant Human Insulin-Like Growth Factor 1, GST-tag

• Cat.No.: IGF1-657H
• Product Overview: IGF1 Human Recombinant produced in E.Coli is a single, non-glycosylated, Polypeptide chain fused to a GST tag and is purified by proprietary chromatographic techniques.

Specification

• Species: Human
• Source: Human
• Tag: GST
• Description: The somatomedins, or insulin-like growth factors (IGFs), comprise a family of peptides that play important roles in mammalian growth and development. IGF1 mediates many of the growth-promoting effects of growth hormone (GH; MIM 139250). Early studies showed that growth hormone did not directly stimulate the incorporation of sulfate into cartilage, but rather acted through a serum factor, termed "sulfation factor," which later became known as "somatomedin" (Daughaday et al., 1972). Three main somatomedins have been characterized: somatomedin C (IGF1), somatomedin A (IGF2; MIM 147470), and somatomedin B (MIM 193190) (Rotwein, 1986; Rosenfeld, 2003).
• Form: IGF1 is supplied in 50mM Tris-Acetate, pH-7.5, 1mM EDTA and 20% Glycerol.
• Physical Appearance: Sterile Filtered clear solution.
• Storage: Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Please avoid freeze thaw cycles.

Gene Information

• Gene Name: IGF1 insulin-like growth factor 1 (somatomedin C) [ Homo sapiens ]
• Official Symbol: IGF1
• Synonyms: IGF1; IGFI; IGF-I; IGF1A; insulin-like growth factor 1; MGF; IGF-IA; IGF-IB; somatomedin-C; OTTHUMP00000195080; OTTHUMP00000195081; OTTHUMP00000195082; OTTHUMP00000195083; OTTHUMP00000195084; mechano growth factor; insulin-like growth factor I; insulin-like growth factor IA; insulin-like growth factor IB
• Gene ID: 3479
• mRNA Refseq: NM_000618
• Protein Refseq: NP_000609
• MIM: 147440
• UniProt ID: P05019
• Chromosome Location: 12q23.2
• Pathway: Adipogenesis; Aldosterone-regulated sodium reabsorption; Androgen Receptor Signaling Pathway; Apoptosis; Diabetes pathways; Dilated cardiomyopathy; Endochondral Ossification; Focal Adhesion; Formation of Platelet plug; Glioma; Hemostasis; Hypertrophic cardiomyopathy (HCM); Id Signaling Pathway; Long-term depression; Melanoma; MicroRNAs in cardiomyocyte hypertrophy; Oocyte meiosis; Pathways in cancer; Platelet Activation; Platelet degranulation; Progesterone-mediated oocyte maturation; Prostate cancer; Response to elevated platelet cytosolic Ca2+; mTOR signaling pathway; p53 signaling pathway
• Function: growth factor activity; hormone activity; insulin receptor binding; insulin-like growth factor receptor binding; integrin binding; protein binding