Active Recombinant Human IGF1 Protein

• Cat.No.: IGF1-23H
• Product Overview: Recombinant Human IGF1 Protein without tag was expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Description: Insulin like growth factor I(IGF-1), also known as somatomedin C, is a secreted protein which belongs to the insulin family. IGF-1 binds IGFI R, IGFII R, and the insulin receptor, although its effects are mediated primarily by IGFI R, which is structurally and functionally related to insulin but has a much higher growth-promoting activity.IGF-1 regulates proliferation and differentiation of a wide variety of cell types. The human mature IGF-1 composes of 70 amino acids and three disulfide bonds with a MW of 7.6kD. The recombinant IGF-1 is modified with additional 13 amino acids at N terminal to increase the activity and stability.
• Bio-activity: The activity was measured by its ability to stimulate the proliferation of 3T3 mouse fibroblast cells.
• Molecular Mass: 9 kDa
• Endotoxin: <1 EU/ μg
• Purity: >95% by SDS-PAGE
• Stability: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. In general: 12 months from date of receipt, -20 to -80 centigrade as supplied. 1 month, 2 to 8 centigrade under sterile conditions after reconstitution. 3 months, -20 to -80 centigrade under sterile conditions after reconstitution.
• Storage Buffer: Lyophilized from a 0.2 μm filtered solution in 50mM NaAOC without carrier protein
• Reconstitution: Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein in sterile 10mM acetic acid containing 0.1% endotoxin-free recombinant human serum albumin.

Gene Information

• Gene Name: IGF1 insulin-like growth factor 1 (somatomedin C) [ Homo sapiens (human) ]
• Official Symbol: IGF1
• Synonyms: IGF1; insulin-like growth factor 1 (somatomedin C); insulin-like growth factor 1; IGF1A; MGF; IGF-IA; IGF-IB; somatomedin-C; mechano growth factor; insulin-like growth factor I; insulin-like growth factor IA; insulin-like growth factor IB; IGFI; IGF-I
• Gene ID: 3479
• mRNA Refseq: NM_000618
• Protein Refseq: NP_000609
• MIM: 147440
• UniProt ID: P05019