Active Recombinant Human Des(1-3)Insulin-like Growth Factor 1

• Cat.No.: IGF1-325H
• Product Overview: Recombinant Human Des(1-3)Insulin-like Growth Factor1 (IGF1) was produced recombinantly.

Specification

• Species: Human
• Tag: Non
• Description: Human Des(1-3)Insulin-like Growth Factor 1 (IGF1) is a 67 amino acid analog of human IGF-I lacking the N-terminal tripeptide Gly-Pro-Glu. Human Des(1-3)IGF1 is more potent than IGF1 in vitro and in vivo. This increased potency is due to reduced binding of human Des(1-3)IGF1 to most of the IGF binding proteins which normally inhibit the biological actions of IGF1. Human Des(1-3)IGF1 binds to the Type 1 IGF receptor with similar affinity to full length IGF1. This is a high quality reagent for use in studies on cell growth, IGF receptors and IGFBPs.
• Purity: >95 % (by HPLC and N-terminal sequence analysis).
• Molecular Weight: 7365 daltons – confirmed by Mass Spectrometry.
• N-terminal Sequence Analysis: 5 residues > 95 % single sequence.
• Activity: Type 1 IGF receptor binding assay: ED₅₀< 10 ng/ml. IGF binding protein assay: ED50 > 100 ng/ml. Stimulation of protein synthesis in rat L6 myoblasts: ED50 < 10 ng/ml.
• Endotoxin: <0.1 EU/µg.
• State And Appearance: Lyophilized white powder. Dried from 0.1 M acetic acid and stored under dry nitrogen at a slight vacuum (-25 kPa).
• Storage: At least 2 years at 2 – 4℃ (lyophilized).

Gene Information

• Gene Name: IGF1 insulin-like growth factor 1 (somatomedin C) [ Homo sapiens ]
• Synonyms: IBP1; IGF-I; IGF-IA; IGFI; MGF; Somatomedin-C; Mechano growth factor; insulin-like growth factor 1; insulin-like growth factor 1 (somatomedin C); somatomedin C; IGF1B_HUMAN; Insulin-like growth factor IB [Precursor]; IGF-IB.
• Gene ID: 3479
• mRNA Refseq: NM_000618
• Protein Refseq: NP_000609
• MIM: 608747
• UniProt ID: P01343
• Chromosome Location: 12q23.2
• Pathway: Focal adhesion; Glioma; Long-term depression; Melanoma; Prostate cancer; mTOR signaling pathway; Hemostasis
• Function: Growth factor activity; Hormone activity; Hormone activity; Insulin receptor binding; Insulin-like growth factor receptor binding; Protein binding