GM-CSF

  • Official Full Name

    colony stimulating factor 2 (granulocyte-macrophage)

  • Overview

    GMCSF is a cytokine that controls the production, differentiation, and function of granulocytes and macrophages. The active form of the protein is found extracellularly as a homodimer. This gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include those encoding interleukins 4, 5, and 13. GM-CSF stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.

  • Synonyms

    granulocyte-macrophage colony-stimulating-factor;GM-CSF;granulocyte-macrophage colony-stimulating factor
Cat.# Product name Source (Host) Species Tag Protein Length Price
GM-CSF-3367M Recombinant Mouse GM-CSF protein, His-tagged HEK293 Mouse His Pro19~Lys141

    Involved Pathway

    GM-CSF involved in several pathways and played different roles in them. We selected most pathways GM-CSF participated on our site, such as Amoebiasis,Cytokine-cytokine receptor interaction,Fc epsilon RI signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with GM-CSF were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interaction BMP2,FLT1,IL25,CCR7,CXCL8B.3,IL12B,TNFSF11,CSH,CCL4L2,IL21R
    Rheumatoid arthritis ATP6V1B1,HLA-DRB4,H2-AB1,IL1A,IL1B,MMP1,ACP5,Ccl12,HLA-DMA,IL-8
    Jak-STAT signaling pathway EPOR,IL20,STAM2,IFNGR2,GM2002,PIK3R3B,IL12RB1,SOCS3B,IL15,IL2RG
    Fc epsilon RI signaling pathway LAT,AKT2,MAPK10,PDPK1,PIK3R3,RAC2,PRKCA,MAPK9,LYN,MS4A2
    Natural killer cell mediated cytotoxicity GRB2,SH3BP2,PPP3R2,HLA-E,ITGB2L,IFNA4,NRAS,RAET1G,VAV2,PIK3R2
    Amoebiasis TGFB1,SERPINB6,PLCB3,CD1D,COL4A3,IFNG,IL12A,GNA11,Casp3,GNAL
    HTLV-I infection ANAPC1,HLA-B,SLC25A6,ETS2,MYB,POLD2,SRF,PPP3R1,PIK3CG,MSX2
    Hematopoietic cell lineage IL7R,CD38,Itga10&Itgb1,CD1d1,CD24,CD36,GYPA,GP1BB,GM13305,IL5RA

    Protein Function

    GM-CSF has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by GM-CSF itself. We selected most functions GM-CSF had, and list some proteins which have the same functions with GM-CSF. You can find most of the proteins on our site.

    Function Related Protein

    Interacting Protein

    GM-CSF has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GM-CSF here. Most of them are supplied by our site. Hope this information will be useful for your research of GM-CSF.

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