Recombinant Human CSF2 therapeutic protein(Sargramostim)

Description :	The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes and macrophages. The active form of the protein is found extracellularly as a homodimer. This gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include those encoding interleukins 4, 5, and 13. The expression product is the active ingredient of Immunex, Leucomax and Leukine.
Source :	Yeast
Species :	Human
Molecular Mass :	14.4 kDa
Protein length :	127 aa
AA Sequence :	APARSPSPSTQPWEHVNAIQEALRLLNLSRDTAAEMNETVEVISEMFDLQEPTCLQTRLELYKQGLRGSLT KLKGPLTMMASHYKQHCPPTPETSCATQIITFESFKENLKDFLLVIPFDCWEPVQE
Endotoxin :	< 1.0 EU per μg of the protein
Purity :	>95%
Storage :	Can be stored at +4 centigrade short term (1-2weeks). For long term storage, aliquot and store at -20 centigrade or -70 centigrade. Avoidrepeated freezing and thawing cycles.
Tag :	Non
Alias :	CSF2; GM CSF; GMCSF; Sargramostim

Gene Name	CSF2 colony stimulating factor 2 (granulocyte-macrophage) [ Homo sapiens ]
Official Symbol	CSF2
Synonyms	CSF2; colony stimulating factor 2 (granulocyte-macrophage); granulocyte-macrophage colony-stimulating factor; GM CSF; GMCSF; granulocyte macrophage colony stimulating factor; molgramostin; sargramostim; CSF; colony-stimulating factor; granulocyte-macrophage colony stimulating factor; MGC131935; MGC138897;
Gene ID	1437
mRNA Refseq	NM_000758
Protein Refseq	NP_000749
MIM	138960
UniProt ID	P04141
Chromosome Location	5q23-q31
Pathway	Amoebiasis, organism-specific biosystem; Amoebiasis, conserved biosystem; Calcineurin-regulated NFAT-dependent transcription in lymphocytes, organism-specific biosystem; Calcium signaling in the CD4+ TCR pathway, organism-specific biosystem; Cytokine Signaling in Immune system, organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem;
Function	cytokine activity; granulocyte macrophage colony-stimulating factor receptor binding; growth factor activity; protein binding;

COA

Cat.No. :	CSF2-P035H
Product Overview :	Recombinant Human Colony Stimulating Factor 2 is a human recombinant granulocyte macrophage colony-stimulating factor (GM-CSF) expressed in yeast. It is a glycoprotein that is 127 residues. Substitution of Leu23 leads to a difference from native protein.