Recombinant Equine GM-CSF

• Cat.No.: GM-CSF-368E
• Product Overview: Recombinant Equine GM-CSF was expressed inYeast.MW= 15.2 kDa (135 aa).

Specification

• Species: Equine
• Source: Yeast
• Tag: Non
• Description: GMCSF is a cytokine that controls the production, differentiation, and function of granulocytes and macrophages. The active form of the protein is found extracellularly as a homodimer. This gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include those encoding interleukins 4, 5, and 13. GM-CSF stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.
• Formulation/ Reconstitution: Lyophilized. Reconstitute with sterile phosphate-buffered saline containing at least 0.1% carrier protein.
• Purification: Ion-exchange chromatography.
• Purity: >95% as visualized by SDS-PAGE analysis.
• Amino Acid Sequence: APTRQPSPVT RPWQHVDAIK EALSLLNNSS DTAAIMNETV EVVSETFDAE ELTCLQTRLK LYKQGLRGSL IKLEGPLTMM ASHYKQHCPP TLETSCATQM ITFKSFKKNL KDFLFEIPFD CWSQPRSKAG LPARS.
• Bioactivity: In testing.
• Stability And Storage: Stable for up to twelve months from date of receipt at -20°C. Stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. Avoid repeated freeze/thaw cycles.

Gene Information

• Gene Name: GM-CSF granulocyte-macrophage colony-stimulating-factor [ Equus caballus ]
• Synonyms: granulocyte-macrophage colony-stimulating-factor; GM-CSF; granulocyte-macrophage colony-stimulating factor
• Gene ID: 100033981
• mRNA Refseq: NM_001081882.1
• Protein Refseq: NP_001075351.1
• Chromosome Location: 14
• Pathway: Cytokine-cytokine receptor interaction; Fc epsilon RI signaling pathway; Hematopoietic cell lineage; Jak-STAT signaling pathway; Natural killer cell mediated cytotoxicity; T cell receptor signaling pathway