Recombinant Equine GM-CSF

• Cat.No.: GM-CSF-368E
• Product Overview: Recombinant Equine GM-CSF was expressed inYeast.MW= 15.2 kDa (135 aa).

Specification

• Cat. No.: GM-CSF-368E
• Description: GMCSF is a cytokine that controls the production, differentiation, and function of granulocytes and macrophages. The active form of the protein is found extracellularly as a homodimer. This gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include those encoding interleukins 4, 5, and 13. GM-CSF stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.
• Source: Yeast.
• Formulation/ Reconstitution: Lyophilized. Reconstitute with sterile phosphate-buffered saline containing at least 0.1% carrier protein.
• Purification: Ion-exchange chromatography.
• Purity: >95% as visualized by SDS-PAGE analysis.
• Amino Acid Sequence: APTRQPSPVT RPWQHVDAIK EALSLLNNSS DTAAIMNETV EVVSETFDAE ELTCLQTRLK LYKQGLRGSL IKLEGPLTMM ASHYKQHCPP TLETSCATQM ITFKSFKKNL KDFLFEIPFD CWSQPRSKAG LPARS.
• Bioactivity: In testing.
• Stability And Storage: Stable for up to twelve months from date of receipt at -20°C. Stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. Avoid repeated freeze/thaw cycles.
• Tag: Non

Gene Information

• Gene Name: GM-CSF granulocyte-macrophage colony-stimulating-factor [ Equus caballus ]
• Synonyms: granulocyte-macrophage colony-stimulating-factor; GM-CSF; granulocyte-macrophage colony-stimulating factor
• Gene ID: 100033981
• mRNA Refseq: NM_001081882.1
• Protein Refseq: NP_001075351.1
• Chromosome Location: 14
• Pathway: Cytokine-cytokine receptor interaction; Fc epsilon RI signaling pathway; Hematopoietic cell lineage; Jak-STAT signaling pathway; Natural killer cell mediated cytotoxicity; T cell receptor signaling pathway

Reviews

01/15/2022

The product's adherence to regulatory standards aligned with our lab's commitment to responsible and transparent research.

07/27/2021

The manufacturer's commitment to meeting regulatory requirements demonstrated its dedication to ethical research practices.

05/19/2019

Compliance with industry standards minimized potential roadblocks in securing approvals for our experiments.

Q&As

How conserved is the sequence of CSF2 among different species?

The sequence of CSF2 is moderately conserved across different species.

What is the typical length of CSF2?

The length of CSF2 protein varies but is typically around 144 amino acids.

What is the main biological function of CSF2?

The primary function of CSF2 is to regulate the production and differentiation of white blood cells.

In what tissues or cells is CSF2 commonly expressed?

CSF2 is often expressed in immune cells, specifically in macrophages, T cells, and endothelial cells.

What does CSF2 stand for?

CSF2 stands for Colony Stimulating Factor 2.

Is CSF2 associated with any specific diseases or conditions?

CSF2 dysregulation has been linked to autoimmune diseases and inflammatory disorders.

Which cellular functions are associated with CSF2?

CSF2 is involved in the stimulation of stem cells to produce granulocytes and monocytes.