CSF1

What is csf1 protein?

Csf1, also known as colony-stimulating factor 1, is a protein that plays a crucial role in the regulation of immune cell function and development. It is primarily produced by cells of the macrophage lineage, such as monocytes and tissue-resident macrophages.

What is the function of csf1 protein?

The main function of Csf1 is to promote the survival, proliferation, and differentiation of monocytes and macrophages. It acts as a growth factor, stimulating the production of these immune cells and enhancing their ability to carry out their immune functions. Csf1 also plays a role in bone development and remodeling, as well as the regulation of female reproductive functions.

Csf1 related signaling pathway

The signaling pathway of CSF1 involves the binding of CSF1 to its receptor, CSF1R (colony-stimulating factor 1 receptor). Upon binding, CSF1 induces the dimerization and autophosphorylation of CSF1R, leading to the activation of downstream signaling molecules such as phosphatidylinositol 3-kinase (PI3K), Akt (protein kinase B), and mitogen-activated protein kinases (MAPKs) including extracellular signal-regulated kinases (ERKs) and p38 MAPK.

Activation of these signaling molecules regulates various cellular processes, including cell proliferation, survival, differentiation, migration, and phagocytosis. CSF1-mediated signaling is vital for the development and function of macrophages, which are essential components of the immune system and play crucial roles in immune responses, tissue homeostasis, and inflammation.

Csf1 Related Diseases

CSF1 plays a crucial role in various diseases and conditions. Imbalances in CSF1 signaling have been implicated in the development and progression of certain cancers, such as breast cancer, ovarian cancer, and prostate cancer. Overexpression of CSF1 has been associated with increased tumor growth, angiogenesis, and metastasis.

In addition, dysregulation of CSF1 signaling has been linked to inflammatory diseases, including rheumatoid arthritis and inflammatory bowel disease. CSF1 promotes the recruitment, differentiation, and activation of macrophages, which play a key role in driving chronic inflammation in these conditions.

Biomedical Application of csf1 Protein

The biomedical applications of Csf1 protein are wide-ranging. Csf1 therapy has been explored in preclinical and clinical studies as a potential treatment for bone-related disorders like osteoporosis and osteoarthritis. Csf1 has also been investigated as a therapeutic target in inflammatory and autoimmune diseases, with the aim of modulating immune cell function and reducing inflammation. In the field of oncology, targeting Csf1 signaling has been explored as a strategy to inhibit tumor growth and metastasis by blocking the recruitment and activation of tumor-associated macrophages. Additionally, Csf1 is being investigated as a potential biomarker for disease prognosis and therapeutic response in certain cancers.

CSF1 has several biochemical functions, for example, cytokine activity,growth factor activity,macrophage colony-stimulating factor receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CSF1 itself. We selected most functions CSF1 had, and list some proteins which have the same functions with CSF1. You can find most of the proteins on our site.

CSF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CSF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CSF1.

SGTA;FHL3;NOTCH2NL;adhC;MYC