Recombinant Human Colony Stimulating Factor 1 (macrophage)

• Cat.No.: CSF1-1875H
• Product Overview: Recombinant HumanCSF1 was expressed in HEK 293 cells. Its molecular weight is 35000 and 40000Dalton.

Specification

• Species: Human
• Source: HEK293
• Tag: Non
• Description: Macrophagecolony-stimulating factor, or CSF1, is a secreted cytokine which influenceshematopoietic stem cells to differentiate into macrophages or other relatedcell types. Eukaryotic cells also produce CSF1 in order to combatintercellular viral infection. (See colony-stimulating factor.) CSF1 binds tothe Colony stimulating factor 1 receptor. It may also be involved indevelopment of the placenta.
• Expression: Human Cell Expressed
• Form: Lyophilized from a0.2 µm sterile filtered solution in 5 mM Tris-HCl + 80 mM Arginine, pH8.0.
• Molecular Weight: 35 and 40 kDa,homodimer, glycosylated
• Purity: > 95% The proteinwas resolved by SDS polyacrylamide gel electrophoresis and the gel wasstained with Coomassie blue.
• Biological Activity: 0.5 to 4 ng/mL ED50
• Endotoxin Level: Endotoxin Free <1EU/µg
• Specific Activity: The specificactivity was determined by the dose-dependent stimulation of theproliferation of mouse M-NFS-60 cells (Mouse Myeloid Leukemia indicator cellline).
• OfficialSymbol: CSF1

Gene Information

• Gene Name: CSF1 colony stimulating factor 1(macrophage) [ Homo sapiens ]
• Synonyms: CSF1; colonystimulating factor 1 (macrophage); MCSF; MGC31930; colony stimulating factor1; OTTHUMP00000013363; OTTHUMP00000013364; Macrophage colony stimulatingfactor; M-CSF; CSF-1; Lanimostim
• Gene ID: 1435
• mRNA Refseq: NM_000757
• Protein Refseq: NP_000748
• MIM: 120420
• UniProt ID: P09603
• Chromosome Location: 1p21-p13
• Pathway: Cytokine-cytokinereceptor interaction; Cytokines and Inflammatory Response; Hematopoietic celllineage; Integrins in angiogenesis; Integrins in angiogenesis; Osteoclastdifferentiation; Rheumatoid arthritis; Rheumatoid arthritis; Signaling eventsmediated by PTP1B; Signaling events mediated by TCPTP
• Function: cytokine activity;growth factor activity; macrophage colony stimulating factor receptorbinding; protein binding; protein homodimerization activity