Il1a
-
Official Full Name
interleukin 1, alpha -
Overview
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer's disease. -
Synonyms
BAF;FAF;Hematopoietin 1;Hematopoietin-1;IL 1 alpha;IL 1;IL 1A;IL-1 alpha;Il-1a;IL1 ALPHA;IL1;IL1A;IL1A_HUMAN;IL1F1;ilia;Interleukin 1 alpha precursor;Interleukin-1 alpha;Interleukin1 alpha;LAF;LEM;Preinterleukin 1 alpha;Pro interleukin 1 alpha;Prointerleukin 1 alpha;IL1-ALPHA
Recombinant Proteins
- Human
- Mouse
- Goat
- Cotton Rat
- Porcine
- Cynomolgus
- Equine
- Rhesus macaque
- Rat
- Canine
- Pig
- Cattle
- Dog
- Horse
- Guinea pig
- Rabbit
- Golden hamster
- E.coli
- Yeast
- CHO
- Human
- HEK293
- C-His
- Mammalian Cells
- Human Cells
- Insect cells
- Non
- GST
- His
- Fc
- His&T7
- His&S
- Avi
- Flag&His
- Avi&His&MBP
- Avi&His
- Avi&Fc&His
- His&Myc
- His&Strep II
- His&SUMO
Involved Pathway
Il1a involved in several pathways and played different roles in them. We selected most pathways Il1a participated on our site, such as MAPK signaling pathway,Cytokine-cytokine receptor interaction,Apoptosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with Il1a were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cytokine-cytokine receptor interaction | PPBP,Cxcl15,IL17RA,CSH,TGFB1,CXCR3.1,CSF2,CXCL8,TNFRSF1A,CCL19 |
| Inflammatory bowel disease (IBD) | IL12RB2,HLA-DPB1,IL4,HLA-DRB5,IL5,IL17A,HLA-DRB1,IL18RAP,IFNGR2,MAF |
| Leishmaniasis | FCGR2A,FCGR1,ITGB1,ITGB2L,FOS,IRAK4,H2-AA,NFKBIB,NFKB1,HLA-DPA1 |
| Pertussis | RELA,MAPK13,Itgam&Itgb2,ITGB1,IRF8,MAPK8,TLR4,CD14,IL-8,RHOA |
| Salmonella infection | WAS,IFNGR1,RHOGD,RAC1A,MAPK13,RAB7A,CDC42,ROCK2A,ARPC4L,NOS2 |
| Graft-versus-host disease | GZMB,KLRD1,Il2,FASLG,HLA-DRA,HLA-DOB,HLA-DRB5,HLA-G,KIR3DL1,HLA-B |
| Rheumatoid arthritis | TNFSF13B,IL17A,HLA-DQA1,ATP6V0A1,ACP5,ATP6V1B2,TGFB1,HLA-DRB5,Il23a; Il12b,TGFB2 |
| Measles | CD3E,OAS1,DOK1,IFNA14,TBK1,CCND3,IFNAR1,RAB9B,SH2D1A,Il2 |
| Osteoclast differentiation | BLNK,PIK3CA,CALCR,STAT2,GAB2,MAPK1,SIRP-BETA,IFNAR2,FCGR2B,MAP2K7 |
Protein Function
Il1a has several biochemical functions, for example, copper ion binding,cytokine activity,interleukin-1 receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Il1a itself. We selected most functions Il1a had, and list some proteins which have the same functions with Il1a. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| copper ion binding | SOD1,COMMD1,LOXL2B,TYRP1,CP,LOX,POLR1B,MOXD1,SCO2,ADNP |
| protein binding | SRGAP3,CDC25C,GPI1,QRICH1,HEPACAM2,MED25,FZD10,RAB14,KIAA1530,UQCRB |
| interleukin-1 receptor binding | Il1f6,IL36RN,IL36G,IL1RAP,IRAK4,IL1F10,IRAK1,IL36A,IL37,TRIP6 |
| cytokine activity | GDF11,IL17A/F3,IFNB,IL6,GPI1,GREM2,SLURP1,BMP8B,CMTM7,TSLP |
Interacting Protein
Il1a has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Il1a here. Most of them are supplied by our site. Hope this information will be useful for your research of Il1a.
CASP1;IL1R2;CASP1;SHARPIN;HAX1
Resources
Research Area
NeuroinflammationConventional/Classical Dendritic Cells
T Cell Cytokine Signaling
Megakaryocytes
IL-1 Family Ligands
Related Services
Related Products
References
- Caniattil, MCDL; Marchioro, AA; et al. Association of Cytokines in Individuals Sensitive and Insensitive to Dust Mites in a Brazilian Population. PLOS ONE 9:-(2014).
- Ramdasi, AY; Arya, RP; et al. Effect of Pregnancy on Anti-HEV Antibody Titres, Plasma Cytokines and the Corresponding Gene Expression Levels in the PBMCs of Patients Presenting with Self-Recovering Clinical and Subclinical Hepatitis E. PLOS ONE 9:-(2014).
