Active Recombinant Human Il1A, HIgG1 Fc-tagged, mutant

• Cat.No.: Il1A-26382H
• Product Overview: The extracellular domain of human IL-1a (NP_000566.3)(Ser113-Ala271) is fused to the N-terminus of the Fc region of mutant human IgG1was expressed in CHO cell.

Specification

• Species: Human
• Source: CHO
• Tag: Fc
• Protein Length: 113-271 a.a.
• Description: The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropiccytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine isproduced by monocytes and macrophages as a proprotein, which is proteolytically processed and released inresponse to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form acytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associatedwith rheumatoid arthritis and Alzheimer"s disease.
• Form: Lyophilized from 0.2μm-filtered solution in PBS.
• Bio-activity: cytokine activity; interleukin-1 receptor binding; protein binding
• Molecular Mass: 44KDa (monomer)
• AA Sequence: Ser113-Ala271
• Endotoxin: <0.06 eu/μg="" as="" determined="" by="" lal="">
• Purity: >98%, by SDS-PAGE under reducing conditions.
• Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
• Reconstitution: Reconstitute at 100μg/ml in sterile PBS.
• Warning: Avoid freeze/thaw cycles.

Gene Information

• Gene Name: IL1A interleukin 1, alpha [ Homo sapiens ]
• Official Symbol: IL1A
• Synonyms: IL1A; interleukin 1, alpha; IL1; interleukin-1 alpha; hematopoietin 1; IL 1A; IL1 ALPHA; IL1F1; preinterleukin 1 alpha; pro interleukin 1 alpha; IL-1 alpha; hematopoietin-1; pro-interleukin-1-alpha; IL-1A; IL1-ALPHA
• Gene ID: 3552
• mRNA Refseq: NM_000575
• Protein Refseq: NP_000566
• MIM: 147760
• UniProt ID: P01583
• Chromosome Location: 2q14
• Pathway: Apoptosis, organism-specific biosystem; Apoptosis, conserved biosystem; Cytokine Signaling in Immune system, organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Cytokines and Inflammatory Response, organism-specific biosystem; FAS pathway and Stress induction of HSP regulation, organism-specific biosystem
• Function: copper ion binding; cytokine activity; interleukin-1 receptor binding; protein binding