Active Recombinant Equine IL1A

• Cat.No.: IL1A-207E
• Product Overview: Recombinant Equine IL1A was expressed in Yeast.

Specification

• Species: Equine
• Source: Yeast
• Tag: Non
• Description: The IL-1 family of cytokines encompasses eleven proteins that each share a similar β-barrel structure and bind to Ig-like receptors. Several of the well characterized members of the IL-1-like cytokines play key roles in the development and regulation of inflammation. IL-1α (IL-1F1), IL-1β (IL-1F2), and IL-18 (IL-1F4) are well-known inflammatory cytokines active in the initiation of the inflammatory reaction and in driving Th1 and Th17 inflammatory responses. In contrast, IL-1 receptor antagonist (IL-1ra; IL-1F3) and IL-36 receptor antagonist (IL-36ra; IL-1F5) reduce inflammation by blocking the binding of the agonist receptor ligands. IL-33 (IL-1F11) is thought to function as an 'alarmin' released following cell necrosis to alerting the immune system to tissue damage or stress. The biological properties of IL-37 (IL-1F7) are mainly those of down-regulating inflammation.
• Form: Lyophilized.
• Bio-activity: In testing
• Molecular Mass: 18.1 kDa
• AA Sequence: SVHYNFQSNT KYNFMRIVNH QCTLNDALNQ SVIRDTSGQY LATAALNNLD DAVKFDMGAY TSEEDSQLPV TLRISKTRLF VSAQNEDEPV LLKEMPDTPK TIKDETNLLF FWERHGSKNY FKSVAHPKLF IATKQGKLVH MARGQPSITD FQILDNQF (158)
• Purity: >95% as visualized by SDS-PAGE analysis.
• Storage: Stable for up to twelve months from date of receipt at °C. Stable for at least 3 months when stored in working aliquots with a carrier protein at °C. Avoid repeated freeze/thaw cycles.
• Reconstitution: Reconstitute with sterile phosphate-buffered saline containing at least 0.1% carrier protein.

Gene Information

• Gene Name: IL1A interleukin 1, alpha [ Equus caballus (horse) ]
• Official Symbol: IL1A
• Synonyms: IL1A; interleukin 1, alpha; interleukin-1 alpha; IL-1 alpha
• Gene ID: 100064969
• mRNA Refseq: NM_001082500
• Protein Refseq: NP_001075969
• UniProt ID: Q28385
• Chromosome Location: 15
• Pathway: Cytokine-cytokine receptor interaction; Hematopoietic cell lineage; Inflammatory bowel disease (IBD)